{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T02:32:27Z","timestamp":1767839547480,"version":"3.49.0"},"reference-count":23,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2003,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine the effect on fertility of\nlarge-volume uterine lavage with lactated Ringer\u2019s\nsolution (LRS) performed immediately prior to insemination\nin mares.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Prospective randomized controlled study.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201420 mares.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Control mares (n = 10) were inseminated\nwith 1 billion (estimated before cooling) progressively\nmotile spermatozoa that had been cooled in a\npassive cooling unit for 24 hours. Mares (n = 10) in\nthe treatment group were inseminated with 1 billion\nprogressively motile spermatozoa (cooled as\ndescribed for control mares) immediately after uterine\nlavage with 4 L of sterile LRS.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014There were no significant differences in\npregnancy rates or size of the embryonic vesicle on\ndays 12, 13, and 14 after ovulation between control\nand treated mares.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results indicate\nthat uterine lavage with LRS can be performed immediately\nprior to insemination without adversely affecting\nfertility in mares. This is clinically important, because\ninsemination may be necessary when a mare has\ninflammation-associated fluid (detectable ultrasonographically)\nin the uterus; removal of the fluid is desirable,\nbecause it adversely affects spermatozoal motility\nand fertility. This situation typically arises when mares\nrequire rebreeding after they have developed persistent\nmating-induced endometritis or are inseminated multiple\ntimes in a 24-hour period (during the period of physiologic\nmating-induced inflammation), which is a common\npractice when using cooled or frozen-thawed\nsemen. 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