{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:34:08Z","timestamp":1793331248369,"version":"4.5.0"},"reference-count":20,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2003,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine clinical, clinicopathologic,\nand radiographic abnormalities in dogs with coccidioidomycosis.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Retrospective case series.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201424 dogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Clinical information and results of clinicopathologic\ntesting were obtained from medical\nrecords. Thoracic radiographs were reviewed to characterize\nabnormalities.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Dogs ranged from 1 to 10 years old at the\ntime of diagnosis, with 12 dogs being between 1 and\n3 years old. Historical complaints included cough,\nlameness, signs of head or neck pain, and difficulty\nbreathing. Mild anemia, neutrophilia, and monocytosis\nwere common. All dogs had hypoalbuminemia,\nand 8 of 15 had hyperglobulinemia. Thoracic radiographs\nof 19 dogs were reviewed. Pulmonary infiltrates\nwere seen in 13 dogs, with an interstitial pattern\nof infiltration being most common. Hilar lymphadenopathy\nwas seen radiographically in 10 dogs.\nSerum from 20 dogs was tested for antibodies\nagainst <jats:italic>Coccidioides immitis<\/jats:italic>. One dog was positive\nfor IgM antibodies, 5 were positive for IgM and IgG\nantibodies, and 14 were positive for IgG antibodies.\nQuantitative IgG titers measured in 14 dogs ranged\nfrom 1:2 to 1:128 (median and mode, 1:32). In 6 dogs,\nhistologic examination of biopsy samples revealed\nfungal spherules ranging from 8 to 70 \u03bcm in diameter.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results suggest\nthat in dogs, coccidioidomycosis may be associated\nwith a wide spectrum of nonspecific respiratory and\nmusculoskeletal abnormalities. The chronic nature of\nthe disease makes diagnosis difficult, even in regions in\nwhich the organism is endemic. 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