{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T17:01:08Z","timestamp":1769101268827,"version":"3.49.0"},"reference-count":35,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2003,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To evaluate the outcome of thermokeratoplasty\nfor treatment of ulcerative keratitis and bullous\nkeratopathy secondary to corneal endothelial disease\nin dogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Retrospective study.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201413 dogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedures<\/jats:bold>\u2014Medical records from 1994 to 2001 for\ndogs evaluated because of ulcerative keratitis and\nbullous keratopathy and treated with thermokeratoplasty\nwere reviewed.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014There were 7 spayed females, 5 castrated\nmales, and 1 sexually intact male, ranging from 6 to\n16 years of age. Ten dogs had endothelial degeneration,\nand 3 dogs had breed-related endothelial dystrophy.\nAll dogs had bullous keratopathy, characterized\nby microbullae formation that was detected via biomicroscopy.\nRecurrent or nonhealing corneal ulcers\nwere detected unilaterally in 5 dogs and bilaterally in\n8 dogs. Mean \u00b1 SD duration from thermokeratoplasty\nuntil ulcerations were healed for all dogs was 2.2 \u00b1\n1.1 weeks. All dogs that underwent thermokeratoplasty\nfor nonhealing corneal ulceration secondary to\nendothelial disease and corneal edema had epithelial\nwound healing and resolution of corneal ulceration.\nMean duration of treatment (ie, topical treatment\nrequired until resolution of ulceration) was significantly\nless after thermokeratoplasty than duration of\ntreatment (with multiple treatments) prior to referral.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014It may be\nnecessary to perform thermokeratoplasty of the\nentire cornea to prevent recurrence of ulcerations\nin areas that have not been treated with thermokeratoplasty.\n(<jats:italic>J Am Vet Med Assoc<\/jats:italic> 2003;222:\n607\u2013612)<\/jats:p>","DOI":"10.2460\/javma.2003.222.607","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T18:45:13Z","timestamp":1138041913000},"page":"607-612","source":"Crossref","is-referenced-by-count":41,"title":["Use of thermokeratoplasty for treatment of ulcerative keratitis and bullous keratopathy secondary to corneal endothelial disease in dogs: 13 cases (1994\u20132001)"],"prefix":"10.2460","volume":"222","author":[{"given":"Tammy Miller","family":"Michau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian C.","family":"Gilger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Maggio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael 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