{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T01:13:43Z","timestamp":1774660423104,"version":"3.50.1"},"reference-count":21,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2003,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine aortic ejection velocity in\nhealthy adult Boxers with soft ejection murmurs without\novert structural evidence of left ventricular outflow\ntract obstruction and in healthy Boxers without\ncardiac murmurs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Retrospective study.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u2014201 Boxers.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Dogs were examined independently by\n2 individuals for evidence of a cardiac murmur, and a\nmurmur grade was assigned. Maximal instantaneous\n(peak) aortic ejection velocity was measured by\nmeans of continuous-wave Doppler echocardiography\nfrom a subcostal location. Forty-eight dogs were\nreexamined approximately 1 year later.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014A soft (grade 1, 2, or 3) left-basilar ejection\nmurmur was detected in 113 (56%) dogs. Overall\nmedian aortic ejection velocity was 1.91 m\/s (range,\n1.31 to 4.02 m\/s). Dogs with murmurs had significantly\nhigher aortic ejection velocities than did those\nwithout murmurs (median, 2.11 and 1.72 m\/s, respectively).\nAuscultation of a murmur was 87% sensitive\nand 66% specific for the identification of aortic ejection\nvelocity &gt; 2.0 m\/s. An ejection murmur and aortic\nejection velocity &gt; 2.0 m\/s were identified in 73\n(36%) dogs. For most dogs, observed changes in\nmurmur grade and aortic ejection velocity during a follow-up examination 1 year later were not clinically\nimportant.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results\nsuggested that ejection murmurs were common\namong healthy adult Boxers and that Boxers with\nmurmurs were likely to have high (&gt; 2.0 m\/s) aortic\nejection velocities. The cause of the murmurs in\nthese dogs is unknown. (<jats:italic>J Am Vet Med Assoc<\/jats:italic>\n2003;222:770\u2013774)<\/jats:p>","DOI":"10.2460\/javma.2003.222.770","type":"journal-article","created":{"date-parts":[[2006,7,7]],"date-time":"2006-07-07T20:21:29Z","timestamp":1152303689000},"page":"770-774","source":"Crossref","is-referenced-by-count":22,"title":["Aortic ejection velocity in healthy Boxers with soft cardiac murmurs and Boxers without cardiac murmurs: 201 cases (1997\u20132001)"],"prefix":"10.2460","volume":"222","author":[{"given":"Shianne L.","family":"Koplitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn M.","family":"Meurs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan W.","family":"Spier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Bonagura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia Luis","family":"Fuentes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola A.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.147.6.152"},{"key":"p_2","first-page":"220","volume":"33","author":"Luis Fuentes V","year":"1993","journal-title":"Vet Ann"},{"key":"p_3","doi-asserted-by":"publisher","DOI":"10.1016\/S1760-2734(06)70014-5"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1998.tb03722.x"},{"key":"p_5","first-page":"647","author":"Buchanan JW","year":"1992","journal-title":"Philadelphia: WB Saunders Co"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1994.tb03262.x"},{"key":"p_7","first-page":"822","author":"Lehmkuhl LB","year":"1995","journal-title":"Philadelphia: WB Saunders Co"},{"key":"p_8","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1152\/jappl.1998.85.4.1368","volume":"85","author":"Stepien RL","year":"1998","journal-title":"J Appl Physiol"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90287-Y"},{"key":"p_11","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(76)80113-5"},{"key":"p_12","first-page":"811","volume":"30","author":"O'Grady MR","year":"1989","journal-title":"Can Vet J"},{"key":"p_13","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1748-5827.2000.tb03140.x","volume":"41","author":"French A","year":"2000","journal-title":"J Small Anim Pract"},{"key":"p_14","first-page":"46","author":"Sisson DD","year":"1999","journal-title":"Philadelphia: WB Saunders Co"},{"key":"p_15","doi-asserted-by":"crossref","first-page":"192","DOI":"10.2460\/ajvr.1994.55.02.192","volume":"55","author":"Lehmkuhl LB","year":"1994","journal-title":"Am J Vet Res"},{"key":"p_16","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/S0195-5616(98)50126-X","volume":"28","author":"Bonagura JD","year":"1998","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"p_18","doi-asserted-by":"publisher","DOI":"10.1892\/0891-6640(2001)015<0430:UOTIEO>2.3.CO;2"},{"key":"p_19","first-page":"260","author":"Kienle RD","year":"1998","journal-title":"St Louis: Mosby"},{"key":"p_20","doi-asserted-by":"publisher","DOI":"10.1016\/S1760-2734(06)70003-0"},{"key":"p_21","doi-asserted-by":"crossref","first-page":"543","DOI":"10.2460\/ajvr.1991.52.04.543","volume":"52","author":"Brown DJ","year":"1991","journal-title":"Am J Vet Res"},{"key":"p_22","first-page":"185","volume":"55","author":"Yuill CD","year":"1991","journal-title":"Can J Vet Res"},{"key":"p_23","doi-asserted-by":"publisher","DOI":"10.1892\/0891-6640(2001)15<427:EPITCL>2.0.CO;2"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/222\/6\/javma.2003.222.770.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/222\/6\/javma.2003.222.770.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/222\/6\/javma.2003.222.770.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T13:41:40Z","timestamp":1741354900000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/222\/6\/javma.2003.222.770.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3,15]]},"references-count":21,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.2460\/javma.2003.222.770","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2003,3,15]]}}}