{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:37:54Z","timestamp":1792802274448,"version":"4.5.0"},"reference-count":46,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2003,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine taurine status in a large\ngroup of Newfoundlands related by environment,\ndiet, or breeding to a dog with dilated cardiomyopathy\nand taurine deficiency.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Prospective study.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201419 privately owned Newfoundlands\nbetween 5 months and 11.5 years old that had been\nfed commercial dry diets meeting established nutrient\nrecommendations.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Diet histories were obtained, and blood,\nplasma, and urine taurine concentrations and plasma\nmethionine and cysteine concentrations were measured.\nIn 8 dogs, taurine concentrations were measured before\nand after supplementation with methionine for 30 days.\nOphthalmic examinations were performed in 16 dogs;\nechocardiography was performed in 6 dogs that were\ntaurine deficient.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Plasma taurine concentrations ranged from\n3 to 228 nmol\/mL. Twelve dogs had concentrations\n&lt; 40 nmol\/mL and were considered taurine deficient.\nFor dogs with plasma concentrations &lt; 40 nmol\/mL,\nthere was a significant linear correlation between\nplasma and blood taurine concentrations. For dogs\nwith plasma concentrations &gt; 40 nmol\/mL, blood taurine\nconcentrations did not vary substantially. Taurine-deficient\ndogs had been fed lamb meal and rice diets.\nRetinal degeneration, dilated cardiomyopathy, and\ncystinuria were not found in any dog examined for\nthese conditions. The taurine deficiency was reversed\nby a change in diet or methionine supplementation.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results indicate\na high prevalence of taurine deficiency among an\nenvironmentally and genetically related cohort of\nNewfoundlands fed apparently complete and balanced\ndiets. Blood taurine concentrations indicative of taurine\ndeficiency in Newfoundlands may be substantially\nless than concentrations indicative of a deficiency in\ncats. 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