{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:38:57Z","timestamp":1761662337379,"version":"3.38.0"},"reference-count":14,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2003,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To assess the use of flunixin meglumine\nas an adjunct treatment for diarrhea in calves.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Clinical trial.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u2014115 calves with diarrhea that were 1 to 21\ndays old at enrollment.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Calves that developed diarrhea were\nrandomly assigned to receive no flunixin meglumine\n(controls), a single dose of flunixin meglumine\n(2.2 mg\/kg [1.0 mg\/lb]), or 2 doses of flunixin\nmeglumine administered 24 hours apart. Serum\nIgG concentration and PCV were measured prior to\nenrollment in the trial. Calves were evaluated daily\nto determine rectal temperature, fecal consistency,\ndemeanor, and skin elasticity score . The primary\nanalytic outcome was days of sickness (morbiddays).<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Calves with fecal blood and treated with a\nsingle dose of flunixin meglumine had fewer morbiddays\nand antimicrobial treatments, compared with\ncontrols. Although not significant, calves given 2\ndoses of flunixin meglumine in 24 hours had fewer\nmorbid-days than untreated control calves.\nRegardless of severity of diarrhea, calves without\nfecal blood did not benefit from the use of flunixin.\nFor calves with fecal blood, failure of passive transfer\n(low serum IgG concentration) was an independent\nrisk factor for increased morbid-days.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Treatment\nwith a single dose of flunixin meglumine resulted in\nfewer antimicrobial treatments and morbid-days in\ncalves with fecal blood. As observed in other studies,\ncalves with failure of passive transfer were at high\nrisk for poor outcomes. This emphasizes the importance\nof developing and implementing effective\ncolostrum delivery programs on dairy farms. (<jats:italic>J Am Vet Med Assoc<\/jats:italic> 2003;223:1329\u20131333)<\/jats:p>","DOI":"10.2460\/javma.2003.223.1329","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T18:48:33Z","timestamp":1138042113000},"page":"1329-1333","source":"Crossref","is-referenced-by-count":22,"title":["Evaluation of flunixin meglumine as an adjunct treatment for diarrhea in dairy calves"],"prefix":"10.2460","volume":"223","author":[{"given":"Staci C.","family":"Barnett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William M.","family":"Sischo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale A.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James P.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"journal-title":"Colo: USDA:APHIS","first-page":"1","year":"1994","key":"p_1_352"},{"key":"p_2_353","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1939-1676.1998.tb02099.x","volume":"12","author":"Tyler JW","year":"1998","journal-title":"J Vet Intern Med"},{"key":"p_3_354","first-page":"352","author":"Naylor JM","year":"2002","journal-title":"St Louis: Mosby Year Book Inc"},{"key":"p_4_355","unstructured":"Plumb DC. 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