{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:50:17Z","timestamp":1791118217146,"version":"4.1.0"},"reference-count":33,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2003,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    \u2014To evaluate the effect of daily oral administration\nof decoquinate to neonatal calves experimentally\nchallenged with various numbers of\n                    <jats:italic>Cryptosporidium\nparvumo<\/jats:italic>\n                    ocysts.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design<\/jats:bold>\n                    \u2014Clinical trial.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Animals<\/jats:bold>\n                    \u201475 calves.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedure<\/jats:bold>\n                    \u2014Calves were purchased from a commercial\ndairy during a 5-week period. Calves were housed\nin individual hutches and fed milk replacer with or\nwithout decoquinate (2 mg\/kg [0.9 mg\/lb per day]).\nCalves were randomly assigned to treatment and 1 of\n5 challenge groups (0, 50, 100, 1000, or 10,000\n                    <jats:italic>C\nparvum<\/jats:italic>\n                    oocysts in 60 mL of saline [0.9% NaCl] solution\nadministered PO on the day after arrival). Calves\nwere maintained in the study for as long as 28 days.\nCalves were clinically assessed for diarrhea and dehydration.\nFecal samples were submitted for oocyst\nenumeration 3 times each week.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u2014Treatment did not affect number of days to\nfirst watery feces (diarrhea), number of days to first\noocyst shedding, or duration of diarrhea or oocyst shedding.\nDuration of oocyst shedding was significantly\nassociated with challenge dose of oocysts administered\nto calves and number of days to first oocyst shedding.\nDuration of diarrhea and number of days to first oocyst\nshedding were significantly associated with week of\narrival and number of days to first watery diarrhea.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\n                    \u2014Daily treatment\nwith decoquinate at the dosage used in this\nstudy did not affect oocyst shedding or clinical signs\nassociated with cryptosporidiosis. However, there\nwas an indication that if the number of oocysts calves\nreceived could be reduced, then the duration of\noocyst shedding and, hence, environmental loading\nof\n                    <jats:italic>C parvum<\/jats:italic>\n                    oocysts could be reduced. (\n                    <jats:italic>J Am Vet\nMed Assoc<\/jats:italic>\n                    2003;223:839\u2013845)\n                  <\/jats:p>","DOI":"10.2460\/javma.2003.223.839","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T13:47:08Z","timestamp":1138024028000},"page":"839-845","source":"Crossref","is-referenced-by-count":44,"title":["Prophylactic use of decoquinate for infections with Cryptosporidium parvum in experimentally challenged neonatal calves"],"prefix":"10.2460","volume":"223","author":[{"given":"Dale A.","family":"Moore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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