{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T08:13:37Z","timestamp":1784621617372,"version":"3.55.0"},"reference-count":46,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2003,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine whether 4 mg of estradiol\ncypionate (ECP) administered prophylactically to highrisk\npostparturient dairy cows decreases incidence of\npostpartum metritis.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Randomized, placebo-controlled, triplemasked\nclinical trial.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u2014250 postparturient dairy cows in a herd\nwith postparturient hypocalcemia, retained fetal\nmembranes, dystocia, stillbirth, or twins.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Cows were given 4 mg of ECP (treatment)\nor 2 mL of vegetable oil (control) by IM injection\nwithin 24 to 36 hours of calving. Monitoring rectal\ntemperatures and evaluation for metritis was performed\nonce daily for 10 days. Cows with fever \u2265\n39.7\u00b0C (103.5\u00b0F) were treated with 1.5 g of ceftiofur\nhydrochloride.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014When assessed by ordinal logistic regression,\nthere were no differences between groups in\nincidence of mild or severe metritis. Cows that calved\nduring the second or third quarter of the year were at\nincreased risk of metritis, compared with those that\ncalved during the fourth quarter. Following stratification\nby lactation (first and \u2265 2), it was observed that\nmultiparous cows that did not receive antimicrobials\nduring the first 3 days of the postparturient period\nwere 5 times as likely to have metritis, compared with\ncows treated with antimicrobials on the basis of fever\nor other concurrent disease.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Prophylactic\nadministration of ECP to dairy cows at high risk for\nmetritis did not reduce risk for metritis. Treating multiparous\ncows with antimicrobials on the basis of\nfever during the early postpartum period was associated\nwith decreased incidence of metritis. 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