{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T12:42:13Z","timestamp":1777293733861,"version":"3.51.4"},"reference-count":30,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2004,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To identify factors affecting prognosis,\noutcome, and complications associated with pemphigus\nfoliaceus in dogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Retrospective study.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201443 dogs with pemphigus foliaceus.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Medical records were reviewed for signalment,\nage at diagnosis, duration to diagnosis, body\narea affected, initial immunosuppressive regimens\nand concurrent use of antimicrobials and sucralfate or\nhistamine receptor 2 blocking agent, adverse effects\nof treatment, duration of treatment, number of visits\nfor follow-up care, cause of death, and credentials of\nthe veterinarians responsible for continued care.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014The case fatality rate was 60.5%. Factors\nsignificantly correlated with survival time included\nconcurrent use of antimicrobials during initiation of\nimmunosuppressive treatment and a lower number\nof adverse effects to treatment. Treatment times lasting\nmore than 10 months from diagnosis correlated\nsignificantly with survival.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Treatment with\nor prophylactic use of antimicrobials may be warranted\nduring initial immunosuppressive treatment. The inverse\ncorrelation between survival time and number of\nadverse treatment effects was not unexpected because\nit was reflective of the owners' decision to euthanatize\ntheir dogs and of corticosteroid-related secondary diseases.\nSurvival beyond the tenth month of treatment\npredicted long-term survival, which suggests that dogs\nrequire careful management during the early months of\ntreatment. 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