{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T06:43:02Z","timestamp":1757313782634,"version":"3.38.0"},"reference-count":34,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2004,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To compare prevalence of organisms and\nhistologic changes in eyes from dogs with blastomycosis\nthat were either untreated or undergoing treatment\nwith itraconazole.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Retrospective study.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201436 dogs with endophthalmitis associated\nwith blastomycosis.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Signalment, results of ophthalmic examination,\nand duration of treatment with itraconazole\nwere extracted from medical records. Histologic sections\nfrom eyes were examined for prevalence and\nviability (ie, budding) of fungal organisms. A scoring\nsystem was devised to assess the degree of inflammation.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Clinically, all eyes were blind and had signs\nof severe endophthalmitis. Histologically, the type\nand degree of inflammation and prevalence of\n<jats:italic>Blastomyces dermatitidis<\/jats:italic> were not significantly different\nbetween dogs treated with itraconazole and\nuntreated dogs or among groups of dogs treated for\ndifferent time periods (4 to 14, 15 to 28, or 29 to 72\ndays). Replication of the organisms in vascular tissues\nas well as avascular spaces in the eyes was similar in\ntreated and untreated dogs. Lens rupture was seen in\n12 of 29 (41%) eyes.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Persistence\nof inflammation in eyes of dogs with naturally occurring\nblastomycosis is likely attributable to the continued\npresence of <jats:italic>B dermatitidis<\/jats:italic>, regardless of the\nduration of treatment with itraconazole. Lens capsule\nrupture, a common and previously unreported histologic\nfinding, may contribute to cataract formation and\ncontinued inflammation. 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