{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:53:38Z","timestamp":1787025218222,"version":"build-2736575974"},"reference-count":11,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2004,5,1]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:bold>\n \u2014To determine the effects of cephalexin\nand enrofloxacin on results of 4 commercially available\nurine glucose tests in dogs.\n <\/jats:p>\n \n Animals<\/jats:bold>\n \u20146 healthy adult female dogs.\n <\/jats:p>\n \n Procedure<\/jats:bold>\n \u2014In a crossover design, cephalexin (22 and\n44 mg\/kg [10 and 20 mg\/lb], PO, q 8 h) or enrofloxacin (5\nand 10 mg\/kg [2.3 and 4.5 mg\/lb], PO, q 12 h) was administered\nto dogs for 1 day. Urine samples were tested for\nglucose at 0, 6, and 24 hours after drug administration.\nIn vitro, dextrose was added to pooled glucose-negative\ncanine urine samples containing either no antimicrobial\nor known concentrations of either antimicrobial; urine\nsamples were then tested for glucose.\n <\/jats:p>\n \n Results<\/jats:bold>\n \u2014In vivo, false-positive results were obtained\nby use of a tablet test in the presence of both antimicrobials\nand by use of a strip test in the presence of\ncephalexin. In vitro, false-positive results were\nobtained with the tablet test at the highest urine concentration\nof cephalexin (2,400 \u03bcg\/mL) and with a\nstrip test at the highest concentration of enrofloxacin\n(600 \u03bcg\/mL). Enrofloxacin in urine samples containing\ndextrose caused the urine glucose tests to underestimate\nurine glucose concentration.\n <\/jats:p>\n \n Conclusions and Clinical Relevance<\/jats:bold>\n \u2014Cephalexin\nand enrofloxacin at dosages used in clinical practice\nmay result in false-positive or false-negative urine glucose\nresults, and care should be taken when using\nurine as a basis for identifying or monitoring diabetic\nanimals. (\n J Am Vet Med Assoc<\/jats:italic>\n 2004;224:1455\u20131458)\n <\/jats:p>","DOI":"10.2460\/javma.2004.224.1455","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T13:47:38Z","timestamp":1138024058000},"page":"1455-1458","source":"Crossref","is-referenced-by-count":21,"title":["Evaluation of the effect of cephalexin and enrofloxacin on clinical laboratory measurements of urine glucose in dogs"],"prefix":"10.2460","volume":"224","author":[{"given":"Christine A.","family":"Rees","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn M.","family":"Boothe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"p_1_142","unstructured":"Plumb DC, Donald C. Veterinary drug handbook. 3rd ed. Ames, Iowa: Iowa State University Press, 1999;116."},{"key":"p_2_143","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)92626-8"},{"key":"p_3_144","unstructured":"Epner JA, Denniston PL. 1995 physicians GenR\n x\n . Hanover, NH: Denniston Publishing Inc, 1995;1991."},{"key":"p_4_145","unstructured":"United States Pharmacopoeia. Drug information for the health care professional. 12th ed. Vol 1A. US Rockville, Md: The United States Pharmacopoeia Convention Inc, 1992;173."},{"key":"p_5_146","first-page":"126","author":"Lees GE","year":"1994","journal-title":"Philadelphia: WB Saunders Co"},{"key":"p_6_147","first-page":"36","author":"Graff SL","year":"1983","journal-title":"Philadelphia: JB Lippincott Company Co"},{"key":"p_7_148","unstructured":"University of North Carolina Hospitals. Antimicrobial doses and attainable levels in body fluids. Available at: www.pathology.unc.edu\/labs\/Antibiogram\/doses_levels_a.htm. Accessed June 30, 2003."},{"key":"p_8_149","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1046\/j.1365-2885.1997.00041.x","volume":"20","author":"Monlouis JD","year":"1997","journal-title":"J Vet Pharmacol Ther"},{"key":"p_9_150","first-page":"120","volume":"2","author":"Boothe DM","year":"2001","journal-title":"Vet Ther"},{"key":"p_10_151","first-page":"64","volume":"20","author":"Wackowiez G","year":"1997","journal-title":"J Vet Pharmacol Ther"},{"key":"p_11_152","first-page":"334","volume":"2","author":"Boeckh A","year":"2001","journal-title":"Vet Ther"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/224\/9\/javma.2004.224.1455.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/224\/9\/javma.2004.224.1455.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/224\/9\/javma.2004.224.1455.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T08:40:55Z","timestamp":1741336855000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/224\/9\/javma.2004.224.1455.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5,1]]},"references-count":11,"journal-issue":{"issue":"9"},"URL":"https:\/\/doi.org\/10.2460\/javma.2004.224.1455","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2004,5,1]]}}}