{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:03:13Z","timestamp":1791385393026,"version":"4.3.3"},"reference-count":20,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2004,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To evaluate the efficacy of ceftiofur\nhydrochloride sterile suspension administered parenterally\nfor treatment of acute postpartum metritis\n(APM) in dairy cows.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Multilocation, randomized block, field trial.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u2014406 cows in the first 14 days postpartum.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Cows with rectal temperatures \u2265\n39.5\u00b0C (103.1\u00b0F) without clinical signs of respiratory\nor gastrointestinal tract disease and with a fetid\nvaginal discharge were allocated randomly in\nblocks of 3 to 3 treatment groups: sterile saline\n(0.9% NaCl) solution administered at a dosage of 2\nmL\/45.4 kg (2 mL\/100 lb), SC or IM, once daily for\n5 days (control); or ceftiofur hydrochloride administered\nat a dosage of 1.1 or 2.2 mg of ceftiofur\nequivalents (CE)\/kg (0.5 or 1 mg\/lb, respectively),\nSC or IM, once daily for 5 days. Cows were evaluated\non days 6, 10, and 14, and clinical cure or failure\nto cure was determined. Clinical cure was\ndefined as no additional antimicrobial treatment\nadministered, rectal temperature &lt; 39.5\u00b0C, and\nabsence of a fetid vaginal discharge.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014On day 14, clinical cure rates were 77%,\n65%, and 62% for the 2.2 mg of CE\/kg, 1.1 mg of\nCE\/kg, and control groups, respectively. No significant\ndifferences were detected in clinical cure\nrates between control and treatment groups on day\n10 or 6.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Ceftiofur\nhydrochloride administered at a dosage of 2.2 mg of\nCE\/kg, SC or IM, once daily for 5 days was efficacious for\ntreatment of APM in dairy cows. (<jats:italic>J Am Vet Med Assoc<\/jats:italic>\n2004;224:1634\u20131639)<\/jats:p>","DOI":"10.2460\/javma.2004.224.1634","type":"journal-article","created":{"date-parts":[[2005,12,22]],"date-time":"2005-12-22T11:33:18Z","timestamp":1135251198000},"page":"1634-1639","source":"Crossref","is-referenced-by-count":117,"title":["Efficacy of ceftiofur hydrochloride sterile suspension administered parenterally for the treatment of acute postpartum metritis in dairy cows"],"prefix":"10.2460","volume":"224","author":[{"given":"John R.","family":"Chenault","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph F.","family":"McAllister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Theodore","family":"Chester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J.","family":"Dame","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian M.","family":"Kausche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Robb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"p_1_179","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5877(86)90026-7"},{"key":"p_2_180","first-page":"131","volume":"20","author":"Sandals WCD","year":"1979","journal-title":"Can Vet J"},{"key":"p_3_181","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.3168\/jds.S0022-0302(88)79846-X","volume":"71","author":"Stevenson JS","year":"1988","journal-title":"J Dairy Sci"},{"key":"p_4_182","unstructured":"Radostits OM, Blood DC, Gay CC. Toxemia in the recently calved cow. In: Veterinary medicine, a textbook of the diseases of cattle, sheep, pigs, goats and horses. Philadelphia: Bailliere Tindall, 1994; 44-47."},{"key":"p_5_183","first-page":"675","author":"The","year":"1986","journal-title":"NJ: Merck & Co Inc"},{"key":"p_6_184","unstructured":"Lohuis JACM. Uterine infections in post-partum cows: bacteriology and fertility, in Proceedings. Societe Francaise de Buiatrie, 1998;145-154."},{"key":"p_7_185","doi-asserted-by":"publisher","DOI":"10.1016\/0093-691X(86)90045-2"},{"key":"p_8_186","first-page":"2251","volume":"45","author":"Olson JD","year":"1984","journal-title":"Am J Vet Res"},{"key":"p_9_187","doi-asserted-by":"publisher","DOI":"10.1016\/0093-691X(95)00123-P"},{"key":"p_10_188","first-page":"227","author":"Olson JD","year":"1986","journal-title":"Philadelphia: WB Saunders Co"},{"key":"p_11_189","first-page":"1131","volume":"15","author":"Montes AJ","year":"1993","journal-title":"Compend Contin Educ Pract Vet"},{"key":"p_12_190","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(05)70349-4"},{"key":"p_13_191","unstructured":"Hanzen CH, Houtain J-Y, Laurent Y. Les infections uterines dans l'espece bovine: 2. Therapeutiques anti-infectieuses et hormonales. Point Vet 1996;28:1019-1025."},{"key":"p_14_192","unstructured":"Meisonnier E, Enriquez B. Infections uterines du post-partum. Epidemiologie, bacteriologie et therapeutique anto-infectieuse, in Proceedings. Societe nationales des Groupments Techniques Veterinaires 1998;131-142."},{"key":"p_15_193","unstructured":"Chastant-Maillard S, Aguer D. Pharmacologie de l'uterus infecte: facteurs de choix d'une therapeutique, in Proceedings. Societe Francaise de Buiatrie 1998;167-187."},{"key":"p_16_194","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.3168\/jds.S0022-0302(98)75721-2","volume":"81","author":"Smith BI","year":"1998","journal-title":"J Dairy Sci"},{"key":"p_17_195","unstructured":"SAS\/STAT user's guide: version 6. 4th ed. Cary, NC: SAS Institute Inc, 1989."},{"key":"p_18_196","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2885.2002.00372.x"},{"key":"p_19_197","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.3168\/jds.S0022-0302(01)74644-9","volume":"84","author":"Drillich M","year":"2001","journal-title":"J Dairy Sci"},{"key":"p_20_198","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.219.805"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/224\/10\/javma.2004.224.1634.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/224\/10\/javma.2004.224.1634.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/224\/10\/javma.2004.224.1634.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T13:40:38Z","timestamp":1741354838000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/224\/10\/javma.2004.224.1634.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5,15]]},"references-count":20,"journal-issue":{"issue":"10"},"URL":"https:\/\/doi.org\/10.2460\/javma.2004.224.1634","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2004,5,15]]}}}