{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:54:09Z","timestamp":1787025249968,"version":"build-2736575974"},"reference-count":30,"publisher":"American Veterinary Medical Association (AVMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2004,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    \u2014To determine the efficacy (durations of\nremission and survival) of an alternating-day radiation\nprotocol for incompletely excised histologic grade-III\nsolitary mast cell tumors (MCTs) in dogs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design<\/jats:bold>\n                    \u2014Retrospective study.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Animals<\/jats:bold>\n                    \u201431 dogs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedure<\/jats:bold>\n                    \u2014Radiation (52 Gy in an 18-fraction alternating-day protocol) was delivered to an area bordered\nby margins \u2265 3 cm around the surgical scar and\nto the associated local-regional lymph nodes. Dogs\nwere not given chemotherapeutic agents concurrently\nor after radiation. Information on signalment, duration\nof remission, and survival time was obtained\nfrom medical records.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u2014Median and mean durations of remission\nwere 27.7 and 17.0 months, respectively (range, 1 to\n47 months). Median and mean durations of survival\nwere 28 and 20 months, respectively (range, 3 to 52\nmonths). Dogs with tumors located on the skin of the\npinna, perineum, and prepuce had a median duration\nof remission greater than dogs with tumors located at\nother sites (27.7 and 14.4 months, respectively). Dogs\nwith tumors \u2264 3 cm in maximum diameter before\nsurgery survived longer than dogs with tumors &gt; 3\ncm (31 and 24 months, respectively). The remission\nrate was 65% and survival rate was 71% at 1 year\nafter treatment. Sixteen dogs that were euthanatized\nhad complications associated with local-regional\ntumor progression. Systemic metastases to liver,\nspleen, intestine, and bone marrow were detected in\n1 dog.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\n                    \u2014Without further\ntreatment, incompletely excised grade-III mast\ncell tumors have high local-regional recurrence; local-regional\ntreatment with radiation may effectively be\nused to manage many such tumors. (\n                    <jats:italic>J Am Vet Med\nAssoc<\/jats:italic>\n                    2004;224:79\u201382)\n                  <\/jats:p>","DOI":"10.2460\/javma.2004.224.79","type":"journal-article","created":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T07:56:21Z","timestamp":1135151781000},"page":"79-82","source":"Crossref","is-referenced-by-count":47,"title":["Efficacy of radiation therapy for incompletely resected grade-III mast cell tumors in dogs: 31 cases (1987\u20131998)"],"prefix":"10.2460","volume":"224","author":[{"given":"Kevin A.","family":"Hahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen K.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet K.","family":"Carreras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"p_1_167","first-page":"307","volume":"40","author":"Dorn ER","year":"1968","journal-title":"California. J Natl Cancer Inst"},{"key":"p_2_168","first-page":"2859","volume":"34","author":"Cohen D","year":"1974","journal-title":"Cancer Res"},{"key":"p_3_169","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1748-5827.1973.tb06891.x","volume":"14","author":"Bostock DE","year":"1973","journal-title":"J Small Anim Pract"},{"key":"p_4_170","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1177\/030098588402100503","volume":"21","author":"Patnaik AK","year":"1984","journal-title":"Vet Pathol"},{"key":"p_5_171","first-page":"936","volume":"193","author":"Turrel JM","year":"1988","journal-title":"J Am Vet Med Assoc"},{"key":"p_6_172","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.2460\/javma.1996.209.08.1418","volume":"209","author":"Kravis LD","year":"1996","journal-title":"J Am Vet Med Assoc"},{"key":"p_7_173","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/bjc.1989.193","volume":"59","author":"Bostock DE","year":"1989","journal-title":"Br J Cancer"},{"key":"p_8_174","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1177\/030098589202900503","volume":"29","author":"Ayl RD","year":"1992","journal-title":"Vet Pathol"},{"key":"p_9_175","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1177\/030098589403100602","volume":"31","author":"Simoes JPC","year":"1994","journal-title":"Vet Pathol"},{"key":"p_10_176","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1177\/104063879500700311","volume":"7","author":"Miller DM","year":"1995","journal-title":"J Vet Diagn Invest"},{"key":"p_11_177","doi-asserted-by":"publisher","DOI":"10.1354\/vp.37-1-33"},{"key":"p_12_178","doi-asserted-by":"publisher","DOI":"10.1354\/vp.37-1-40"},{"key":"p_13_179","unstructured":"Fan TM, Kitchell BE. Retrospective analysis of oral mast cell tumors in dogs, in Proceedings. 19th Annu Vet Cancer Soc Conf 1999;40."},{"key":"p_14_180","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2000.216.222"},{"key":"p_15_181","doi-asserted-by":"crossref","first-page":"458","DOI":"10.5326\/0380458","volume":"38","author":"Michels GM","year":"2002","journal-title":"J Am Anim Hosp Assoc"},{"key":"p_16_182","doi-asserted-by":"crossref","first-page":"355","DOI":"10.2460\/javma.1999.215.03.355","volume":"215","author":"McManus PM","year":"1999","journal-title":"J Am Vet Med Assoc"},{"key":"p_17_183","doi-asserted-by":"publisher","DOI":"10.1892\/0891-6640(1999)013<0601:TOCMCT>2.3.CO;2"},{"key":"p_18_184","first-page":"503","author":"Ogilvie GK","year":"1995","journal-title":"NJ: Veterinary Learning Systems"},{"key":"p_19_185","doi-asserted-by":"crossref","unstructured":"Thamm DJ, Mauldin EA, Vail DM. Prednisone and vinblastine chemotherapy for canine mast cell tumor-41 cases (1992-1997). J Vet Intern Med 13;5:491-497.","DOI":"10.1111\/j.1939-1676.1999.tb01468.x"},{"key":"p_20_186","unstructured":"Consultation on the biological behavior and therapy of tumors of domestic animals. Geneva: World Health Organization, 1978."},{"key":"p_21_187","first-page":"211","author":"Hall","year":"1994","journal-title":"Philadelphia: JB Lippincott Co"},{"key":"p_22_188","first-page":"191","author":"Freidman LM","year":"1985","journal-title":"Mass: PSG Publishing Co Inc"},{"key":"p_23_189","doi-asserted-by":"publisher","DOI":"10.2307\/2281868"},{"key":"p_24_190","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","volume":"34","author":"Cox DR","year":"1972","journal-title":"J Roy Stat Soc"},{"key":"p_25_191","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1939-1676.1996.tb02084.x","volume":"10","author":"Al-Sarraf R","year":"1996","journal-title":"J Vet Intern Med"},{"key":"p_26_192","doi-asserted-by":"crossref","first-page":"71","DOI":"10.5326\/0380071","volume":"38","author":"Weisse C","year":"2002","journal-title":"J Am Anim Hosp Assoc"},{"key":"p_27_193","doi-asserted-by":"crossref","first-page":"320","DOI":"10.5326\/15473317-33-4-320","volume":"33","author":"Frimberger AE","year":"1997","journal-title":"J Am Anim Hosp Assoc"},{"key":"p_28_194","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.1998.tb00326.x"},{"key":"p_29_195","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2002.tb01023.x"},{"key":"p_30_196","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1080\/01652176.1998.9694832","volume":"20","author":"Gerritsen RJ","year":"1998","journal-title":"Vet Q"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/224\/1\/javma.2004.224.79.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/224\/1\/javma.2004.224.79.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/224\/1\/javma.2004.224.79.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T09:10:48Z","timestamp":1741338648000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/224\/1\/javma.2004.224.79.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1,1]]},"references-count":30,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.2460\/javma.2004.224.79","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2004,1,1]]}}}