{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:46:51Z","timestamp":1775742411107,"version":"3.50.1"},"reference-count":17,"publisher":"American Veterinary Medical Association (AVMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2004,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine the relationship between\nthe caudolateral curvilinear osteophyte (CCO) and\nosteoarthritis associated with hip dysplasia in dogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Longitudinal cohort study.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201448 Labrador Retrievers from 7 litters.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014In each of 24 sex- and size-matched pairs\nfed the same diet, a restricted-fed dog was fed 25%\nless than a control dog for life. The dogs' hips were\nevaluated in the standard ventrodorsal hip-extended\nradiographic projection at 16, 30, and 52 weeks of age\nand then yearly for life. Histologic examination of hip\njoint tissues was performed on 45 dogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Median age at death was 11.2 years.\nAdjusting for feeding group, dogs with a CCO were\n3.7 times as likely to develop radiographic signs of\nosteoarthritis than those without a CCO. Stratified by\ndiet, 100% of the control dogs with a CCO developed\nradiographic signs of osteoarthritis and 55% of\nrestricted-fed dogs with a CCO developed radiographic\nsigns of osteoarthritis. The CCO was the first\nradiographic change seen in 22 of 29 (76%) dogs with\nosteoarthritis. Overall, 35 of 37 (95%) dogs with a\nCCO had histopathologic lesions of osteoarthritis.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results indicate\na relationship between a CCO on the femoral neck\nand subsequent development of radiographic signs of\nosteoarthritis in Labrador Retrievers evaluated over\ntheir life span. A CCO is an important early radiographic\nindication of osteoarthritis associated with canine hip\ndysplasia. (<jats:italic>J Am Vet Med Assoc<\/jats:italic> 2004;225:233\u2013237)<\/jats:p>","DOI":"10.2460\/javma.2004.225.233","type":"journal-article","created":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T12:20:58Z","timestamp":1135167658000},"page":"233-237","source":"Crossref","is-referenced-by-count":34,"title":["Use of the caudolateral curvilinear osteophyte as an early marker for future development of osteoarthritis associated with hip dysplasia in dogs"],"prefix":"10.2460","volume":"225","author":[{"given":"Michelle Y.","family":"Powers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daryl N.","family":"Biery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis F.","family":"Lawler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard H.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances S.","family":"Shofer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Mayhew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas P.","family":"Gregor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard D.","family":"Kealy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail K.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"p_1_80","first-page":"229","author":"Riser WH","year":"1975","journal-title":"Arnold-Bocklin-Strasse"},{"key":"p_2_81","doi-asserted-by":"crossref","first-page":"642","DOI":"10.2460\/javma.1995.206.05.642","volume":"206","author":"Smith GK","year":"1995","journal-title":"J Am Vet Med Assoc"},{"key":"p_3_82","first-page":"953","author":"Riser WH","year":"1985","journal-title":"Philadelphia: JB Lippincott Co"},{"key":"p_4_83","first-page":"791","volume":"139","author":"Whittington K","year":"1961","journal-title":"J Am Vet Med Assoc"},{"key":"p_5_84","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.1982.tb00710.x"},{"key":"p_6_85","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.1987.tb01714.x"},{"key":"p_7_86","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2002.220.472"},{"key":"p_8_87","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.2460\/ajvr.1993.54.07.1021","volume":"54","author":"Smith GK","year":"1993","journal-title":"Am J Vet Res"},{"key":"p_9_88","doi-asserted-by":"crossref","first-page":"339","DOI":"10.5326\/15473317-34-4-339","volume":"34","author":"Adams WM","year":"1998","journal-title":"J Am Anim Hosp Assoc"},{"key":"p_10_89","unstructured":"Smith GK, Biery DN, Rhodes WH, etal Between- and within-radiologist accuracy of subjective hip scoring of the ventrodorsal hip-extended radiograph, in Proceedings. Int Symp Hip Dysplasia Osteoarthritis Dogs 1996."},{"key":"p_11_90","doi-asserted-by":"crossref","first-page":"222","DOI":"10.2460\/javma.1997.210.02.222","volume":"210","author":"Kealy RD","year":"1997","journal-title":"J Am Vet Med Assoc"},{"key":"p_12_91","first-page":"9","author":"Smith GK","year":"2001","journal-title":"Purina Nutr Forum"},{"key":"p_13_92","doi-asserted-by":"crossref","first-page":"857","DOI":"10.2460\/javma.1992.201.06.857","volume":"201","author":"Kealy RD","year":"1992","journal-title":"J Am Vet Med Assoc"},{"key":"p_14_93","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2000.217.1678"},{"key":"p_15_94","unstructured":"Smith GK, Kealy RD, Biery DN, etal Effects of restricted feeding on onset, incidence and severity of hip dysplasia and osteoarthritis in dogs: diagnostic, therapeutic, and genetic ramifications, in Proceedings. Nestle Purina Symp 2002;21-26."},{"key":"p_16_95","first-page":"9","author":"Ackerman N","year":"1977","journal-title":"Calif Vet"},{"key":"p_17_96","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2002.220.1315"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/225\/2\/javma.2004.225.233.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/225\/2\/javma.2004.225.233.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/225\/2\/javma.2004.225.233.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T13:39:56Z","timestamp":1741354796000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/225\/2\/javma.2004.225.233.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7,15]]},"references-count":17,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.2460\/javma.2004.225.233","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2004,7,15]]}}}