{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T07:02:51Z","timestamp":1794466971942,"version":"4.9.1"},"reference-count":16,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2005,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine the minimal effective\ndosage of omeprazole oral paste for the prevention of\nnaturally occurring ulcers in horses starting race training.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Prospective study.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u2014175 horses.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Horses in the dose selection portion of\nthe study were sham dose treated or received 1 mg\n(0.45 mg\/lb) or 2 mg (0.9 mg\/lb) of omeprazole\/kg,\nPO, every 24 hours for 28 days or 4 mg of omeprazole\/\nkg (1.8 mg\/lb; loading dose), PO, every 24 hours\nfor 4 days, then 1 or 2 mg of omeprazole\/kg, PO,\nevery 24 hours for 24 days. Horses in the dose confirmation\nportion of the study were sham dose treated\nor received 1 mg of omeprazole\/kg, PO, every 24\nhours for 28 days. Gastric ulcer scores at the beginning\nand end of the study were compared.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Sham\u2013dose-treated horses had significantly\nhigher ulcer scores than did horses treated with any\nof the omeprazole dosages evaluated. Among horses\ntreated with omeprazole, there was no significant\ninteraction of dose (1 or 2 mg\/kg) and loading dose;\ntherefore, the lowest effective dose (1 mg\/kg) was\nevaluated in the dose confirmation portion of the\nstudy. In the dose confirmation study, 4 of 39 (10%)\nsham\u2013dose-treated horses remained ulcer free,\nwhich was significantly different from the proportion\nof horses (31\/38 [82%]) receiving 1 mg of omeprazole\/\nkg that remained ulcer free.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results indicated\nthat omeprazole administered at a dosage of\n1 mg\/kg, PO, every 24 hours for 28 days was effective\nfor prevention of gastric ulcers in horses starting race\ntraining. 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