{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T17:10:56Z","timestamp":1773076256829,"version":"3.50.1"},"reference-count":36,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2005,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine analgesic efficacy and adverse effects of preemptive administration of meloxicam or butorphanol in cats undergoing onychectomy or onychectomy and neutering.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Randomized controlled study.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201464 female and 74 male cats that were 4 to 192 months old and weighed 1.09 to 7.05 kg (2.4 to 15.5 lb).<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Cats received meloxicam (0.3 mg\/kg [0.14 mg\/lb], SC) or butorphanol (0.4 mg\/kg [0.18 mg\/lb], SC) 15 minutes after premedication and prior to anesthesia. A single blinded observer measured physiologic variables, assigned analgesia and lameness\nscores, and withdrew blood samples for each cat at baseline and throughout the 24 hours after surgery. Rescue analgesia (butorphanol, 0.4 mg\/kg, IV or SC) or administration of acepromazine (0.025 to 0.05 mg\/kg [0.011 to 0.023 mg\/lb], IV) was allowed.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Meloxicam-treated cats were less lame and had lower pain scores. Cortisol concentration was higher at extubation and lower at 1, 5, and 12 hours in the meloxicam-treated cats. Fewer meloxicam-treated cats required rescue analgesia at 3, 5, 12, and 24 hours after extubation. General impression scores were excellent or good in 75% of meloxicam-treated cats and 44% of \nbutorphanol-treated cats. There was no treatment effect on buccal bleeding time; PCV and BUN concentration decreased in both groups, and glucose concentration decreased in meloxicam-treated cats.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Preoperative administration of meloxicam improved analgesia for 24 hours without clinically relevant adverse effects in cats that underwent onychectomy or onychectomy and neutering and provided safe, extended analgesia,\ncompared with butorphanol. (<jats:italic>J Am Vet Med Assoc<\/jats:italic> 2005;226:913\u2013919)<\/jats:p>","DOI":"10.2460\/javma.2005.226.913","type":"journal-article","created":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T13:11:53Z","timestamp":1135170713000},"page":"913-919","source":"Crossref","is-referenced-by-count":70,"title":["Analgesic efficacy of preoperative administration of meloxicam or butorphanol in onychectomized cats"],"prefix":"10.2460","volume":"226","author":[{"given":"Gwendolyn L.","family":"Carroll","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa B.","family":"Howe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt D.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"p_1_112","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.219.932"},{"key":"p_2_113","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2000.217.685"},{"key":"p_3_114","doi-asserted-by":"crossref","first-page":"246","DOI":"10.2460\/javma.1998.213.02.246","volume":"213","author":"Carroll GL","year":"1998","journal-title":"J Am Vet Med Assoc"},{"key":"p_4_115","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2000.217.1013"},{"key":"p_5_116","doi-asserted-by":"crossref","first-page":"507","DOI":"10.5326\/0380507","volume":"38","author":"Dobbins S","year":"2002","journal-title":"J Am Anim Hosp Assoc"},{"key":"p_6_117","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2002.220.1020"},{"key":"p_7_118","doi-asserted-by":"crossref","first-page":"346","DOI":"10.5326\/15473317-33-4-346","volume":"33","author":"Winkler KP","year":"1997","journal-title":"J Am Anim Hosp Assoc"},{"key":"p_8_119","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(95)02111-6"},{"key":"p_9_120","doi-asserted-by":"publisher","DOI":"10.1007\/BF01839314"},{"key":"p_10_121","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1748-5827.1991.tb00553.x","volume":"32","author":"McKellar QA","year":"1991","journal-title":"J Small Anim Pract"},{"key":"p_11_122","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006254402163"},{"key":"p_12_123","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0195-5616(08)70007-X","volume":"30","author":"Mathews K","year":"2000","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"p_13_124","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1096\/fasebj.12.12.1063","volume":"12","author":"DuBois RN","year":"1998","journal-title":"FASEB J"},{"key":"p_14_125","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2000.61.802"},{"key":"p_15_126","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1748-5827.2001.tb06034.x","volume":"42","author":"Lascelles BDX","year":"2001","journal-title":"J Small Anim Pract"},{"key":"p_16_127","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1748-5827.2000.tb03139.x","volume":"41","author":"Slingsby LS","year":"2000","journal-title":"J Small Anim Pract"},{"key":"p_17_128","first-page":"69","volume":"12","author":"Lee VC","year":"1995","journal-title":"Adv Anesth"},{"key":"p_18_129","unstructured":"Poulson Nautrup B, Justus C. Effects of some veterinary NSAIDs on ex vivo thromboxane production and in vivo urine output in the dog, in Proceedings. Symp Recent Adv Non-steroidal Antiinflammatory Ther Small Anim, 1999;25-28."},{"key":"p_19_130","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2002.tb00074.x"},{"key":"p_20_131","doi-asserted-by":"publisher","DOI":"10.1053\/jvet.2001.24387"},{"key":"p_21_132","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.2460\/ajvr.1996.57.11.1674","volume":"57","author":"Smith JD","year":"1996","journal-title":"Am J Vet Res"},{"key":"p_22_133","doi-asserted-by":"crossref","first-page":"432","DOI":"10.2460\/ajvr.1999.60.04.432","volume":"60","author":"Smith JD","year":"1999","journal-title":"Am J Vet Res"},{"key":"p_23_134","doi-asserted-by":"publisher","DOI":"10.1053\/jvet.2002.31047"},{"key":"p_24_135","unstructured":"Cloutier S, Newberry RC, Cambridge AJ, etalBehavioral signs of pain in cats, in Proceedings. 2002 Am Vet Soc Anim Behav Annu Symp Anim Behav Res 2002;51-54."},{"key":"p_25_136","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1532-950X.1991.tb00340.x","volume":"20","author":"Benson GJ","year":"1991","journal-title":"Vet Surg"},{"key":"p_26_137","first-page":"810","author":"Guyton AC","year":"1991","journal-title":"Philadelphia: WB Saunders Co"},{"key":"p_27_138","first-page":"E21","volume":"247","author":"Esler M","year":"1984","journal-title":"Am J Physiol"},{"key":"p_28_139","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2460\/ajvr.1993.54.01.69","volume":"54","author":"Willemese T","year":"1993","journal-title":"Am J Vet Res"},{"key":"p_29_140","first-page":"1700","volume":"46","author":"Hardie EM","year":"1985","journal-title":"Am J Vet Res"},{"key":"p_30_141","first-page":"438","volume":"23","author":"Sawyer DC","year":"1987","journal-title":"J Am Anim Hosp Assoc"},{"key":"p_31_142","first-page":"155","author":"Turnwald GH","year":"1989","journal-title":"Philadelphia: WB Saunders Co"},{"key":"p_32_143","first-page":"868","volume":"16","author":"Hansen BD","year":"1994","journal-title":"Compend Contin Educ Pract Vet"},{"key":"p_33_144","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/00000542-199209000-00006","volume":"77","author":"Katz J","year":"1992","journal-title":"Anesthesiology"},{"key":"p_34_145","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1213\/00000539-199001000-00006","volume":"70","author":"Tverskoy M","year":"1990","journal-title":"Anesth Analg"},{"key":"p_35_146","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1097\/00000542-199409000-00028","volume":"81","author":"Kavanagh BP","year":"1994","journal-title":"Anesthesiology"},{"key":"p_36_147","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1213\/00000539-199402000-00002","volume":"78","author":"Tverskoy M","year":"1994","journal-title":"Anesth Analg"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/226\/6\/javma.2005.226.913.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/226\/6\/javma.2005.226.913.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/226\/6\/javma.2005.226.913.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T13:39:00Z","timestamp":1741354740000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/226\/6\/javma.2005.226.913.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,15]]},"references-count":36,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.2460\/javma.2005.226.913","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2005,3,15]]}}}