{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:24:21Z","timestamp":1770218661670,"version":"3.49.0"},"reference-count":15,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2005,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To develop a diagnostic test for recurrent\nexertional rhabdomyolysis (RER) in Thoroughbreds that\nrelied on in vitro contracture of muscle biopsy specimens\nand determine whether the inheritance pattern\nof RER diagnosed on the basis of this contracture test\nwas consistent with an autosomal dominant trait.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Clinical trial.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u20148 adult horses with RER and 16 control\nadult horses for development of the contracture test;\n23 foals for inheritance of RER.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014External intercostal muscle biopsy specimens\nfrom the 24 adult horses were tested for contracture\nin response to halothane and caffeine, and\ncriteria for a positive test result were determined.\nThese criteria were then applied to results for the 23\nfoals to determine whether they had RER. Simple\nsegregation analysis was performed to determine\nwhether results were consistent with a dominant pattern\nof inheritance.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Results of the contracture test were positive\nfor 5 of the 12 colts and 4 of the 11 fillies. Results\nof segregation analysis were consistent with an autosomal\ndominant pattern of inheritance. Two sires with\nRER produced colts with RER, supporting the hypothesis\nthat RER had an autosomal, rather than an\nX-linked, inheritance pattern. In addition, in 1\ninstance, an unaffected colt was produced by 2 affected\nparents, which was not consistent with a recessive\nmode of inheritance.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Although the\nexpression of the RER trait is influenced by sex, temperament,\nand diet, among other factors, results from\nthe in vitro muscle contracture test and this breeding\ntrial suggest that RER in Thoroughbreds can be modeled\nas a genetic trait with an autosomal dominant pattern of\ninheritance. ( <jats:italic>J Am Vet Med Assoc<\/jats:italic> 2005;227:762\u2013767)<\/jats:p>","DOI":"10.2460\/javma.2005.227.762","type":"journal-article","created":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T12:37:02Z","timestamp":1135168622000},"page":"762-767","source":"Crossref","is-referenced-by-count":42,"title":["Inheritance of recurrent exertional rhabdomyolysis in Thoroughbreds"],"prefix":"10.2460","volume":"227","author":[{"given":"Patricia K.","family":"Dranchak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie J.","family":"Valberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary W.","family":"Onan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther M.","family":"Gallant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer M.","family":"MacLeay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica C.","family":"McKenzie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio D. 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