{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:12:53Z","timestamp":1782227573707,"version":"3.54.5"},"reference-count":45,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To profile <jats:italic>Streptococcus canis<\/jats:italic> isolates obtained from corneal ulcers in dogs.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>10 dogs.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>PROCEDURES<\/jats:title>\n<jats:p>Medical records were searched to identify dogs diagnosed with ulcerative keratitis by a veterinary ophthalmologist and having a positive corneal culture for <jats:italic>S canis<\/jats:italic> during the year 2020. For each case, clinical findings and outcome were determined, antimicrobial resistance and sensitivity panels were summarized, whole genome sequencing was performed, and isolates were typed using multi-locus sequence typing and genome-based proteome phylogenetic analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>10 <jats:italic>S canis<\/jats:italic> isolates were included from dogs diagnosed with ulcerative keratitis. Dogs were either treated surgically via keratectomy and conjunctival grafting (n = 6) or treated medically (4). Three of 10 corneas failed to heal and required enucleation (2\/6 conjunctival grafts and 1\/4 medically managed corneal ulcers). All three corneal ulcers that failed to heal were associated with <jats:italic>S canis<\/jats:italic> sequence type (ST) 43. Sequence types identified from successfully treated cases included ST8 (n = 1), ST50 (1), ST2 (2), ST27 (1), and ST15 (1). One ST43 isolate was obtained from a dog that healed following a conjunctival graft, however this was the only dog that received an oral antibiotic in addition to topical antibiotics.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Based on this small dataset, <jats:italic>S canis<\/jats:italic> ST43 may be associated with increased virulence and contribute to conjunctival graft failure and progressive corneal collagenolysis. The postoperative administration of an oral antimicrobial may protect against conjunctival graft rejection in dogs specifically due to <jats:italic>S canis<\/jats:italic> ST43.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.22.03.0153","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T15:14:40Z","timestamp":1657898080000},"page":"1507-1513","source":"Crossref","is-referenced-by-count":7,"title":["Streptococcus canis sequence type 43 may be associated with treatment failure in dogs with corneal ulceration"],"prefix":"10.2460","volume":"260","author":[{"given":"Marina L.","family":"Leis","sequence":"first","affiliation":[{"name":"Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne S.","family":"Sandmeyer","sequence":"additional","affiliation":[{"name":"Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus O.","family":"Costa","sequence":"additional","affiliation":[{"name":"Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Canada"},{"name":"Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"3","key":"ref1","series-title":"Vet Pathol","first-page":"387","article-title":"Streptococcal infection in dogs: a retrospective study of 393 cases","volume":"47","author":"Lamm CG","year":"2010","unstructured":"Lamm CG, Ferguson AC, Lehenbauer TW, Love BC. 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