{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:37:01Z","timestamp":1772815021727,"version":"3.50.1"},"reference-count":25,"publisher":"American Veterinary Medical Association (AVMA)","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2022,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Describe clinical features, treatment, and outcomes in dogs with deep neck infections.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>19 dogs undergoing surgical treatment of deep neck infections from January 1, 2015, through December 31, 2020.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>PROCEDURES<\/jats:title>\n<jats:p>Retrospective record review was conducted, with data collected including clinical signs; neutrophil-to-lymphocyte ratio (NLR); diagnostic imaging, surgical, and histopathologic findings; and follow-up. Spearman correlation and Wilcoxon rank sum were used to compare variables to NLR.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>All dogs had cervical swelling, and 9 were febrile. On CT, a distinct mass or abscess (7\/13) or abscessed lymph node (4\/13) was common, with contrast enhancement (10\/13), fluid tracking (8\/13), and displacement of the trachea, pharynx, or larynx (6\/13) also frequently seen. Foreign material was suspected on CT for 4 dogs and was identified at surgery or histopathology for 4 dogs, only 1 of which was suspected on CT. Histopathology most commonly revealed pyogranulomatous inflammation (14\/15). Increasing NLR was moderately correlated to a decreased duration of clinical signs before presentation (\u03c1 = \u20130.548; <jats:italic>P<\/jats:italic> = .035) and an increased length of hospitalization (\u03c1 = 0.645; <jats:italic>P<\/jats:italic> = .009). Bacterial culture was submitted for all dogs, and polymicrobial infections were common (8\/19). Broad-spectrum empirical antimicrobials were commonly prescribed. Change in antimicrobial treatment based on culture was uncommon (3\/19). All dogs survived to hospital discharge; 18 dogs with long-term follow-up had complete resolution of clinical signs.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>CT was useful to plan for surgery, and surgical treatment resulted in resolution of clinical signs in all dogs with long-term follow-up available. Empirical antimicrobial treatment, such as amoxicillin\u2013clavulanic acid or ampicillin-sulbactam, should be considered.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.22.04.0169","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T12:17:25Z","timestamp":1657541845000},"page":"1820-1826","source":"Crossref","is-referenced-by-count":2,"title":["Surgical treatment of deep neck infections in 19 dogs"],"prefix":"10.2460","volume":"260","author":[{"given":"Meenakshi","family":"Rajeev","sequence":"first","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandy L.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad W.","family":"Schmiedt","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet A.","family":"Grimes","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"5","key":"ref1","series-title":"Vet Surg","first-page":"383","article-title":"Oropharyngeal penetrating injuries in 50 dogs: a retrospective study","volume":"29","author":"Griffiths LG","year":"2000","unstructured":"Griffiths LG, Tiruneh R, Sullivan M, Reid SW. Oropharyngeal penetrating injuries in 50 dogs: a retrospective study. Vet Surg. 2000; 29(5):383\u2013388. doi:10.1053\/jvet.2000.914010999451"},{"issue":"11","key":"ref2","series-title":"J Am Vet Med Assoc","first-page":"1201","article-title":"Grass awn migration in dogs and cats: a retrospective study of 182 cases","volume":"182","author":"Brennan KE","year":"1983","unstructured":"Brennan KE, Ihrke PJ. Grass awn migration in dogs and cats: a retrospective study of 182 cases. J Am Vet Med Assoc. 1983; 182(11):1201\u20131204."},{"issue":"6","key":"ref3","series-title":"J Am Vet Med Assoc","first-page":"917","article-title":"Cutaneous actinomycosis and nocardiosis in dogs: 48 cases (1980\u20131990)","volume":"201","author":"Kirpensteijn J","year":"1992","unstructured":"Kirpensteijn J, Fingland RB. Cutaneous actinomycosis and nocardiosis in dogs: 48 cases (1980\u20131990). J Am Vet Med Assoc. 1992; 201(6):917\u2013920.1399806"},{"key":"ref4","series-title":"Vet Med Int","first-page":"3089282","article-title":"Microbial isolates from vegetable foreign bodies inhaled by dogs","volume":"2018","author":"Flisi S","year":"2018","unstructured":"Flisi S, Dall\u2019Aglio M, Spadini C, Cabassi CS, Quintavalla F. Microbial isolates from vegetable foreign bodies inhaled by dogs. Vet Med Int. 2018;2018:3089282. doi:10.1155\/2018\/308928230622694"},{"key":"ref5","series-title":"Textbook of Veterinary Internal Medicine: Diseases of the Dog and the Cat","first-page":"1469","article-title":"Oral and salivary gland disorders","author":"Reiter AM","year":"2017","unstructured":"Reiter AM, Soltero-Rivera MM. Oral and salivary gland disorders. In: Ettinger SJ, Feldman EC, eds. Textbook of Veterinary Internal Medicine: Diseases of the Dog and the Cat. 8th ed. Elsevier Saunders; 2017:1469\u20131476."},{"issue":"2","key":"ref6","series-title":"J Am Anim Hosp Assoc","first-page":"99","article-title":"Computed tomographic diagnosis of nongastrointestinal foreign bodies in dogs","volume":"43","author":"Jones JC","year":"2007","unstructured":"Jones JC, Ober CP. Computed tomographic diagnosis of nongastrointestinal foreign bodies in dogs. J Am Anim Hosp Assoc. 2007; 43(2):99\u2013111. doi:10.5326\/043009917339287"},{"issue":"4","key":"ref7","series-title":"J Am Anim Hosp Assoc","first-page":"250","article-title":"Parotid duct foreign body in a dog diagnosed with CT","volume":"49","author":"Goldsworthy SJ","year":"2013","unstructured":"Goldsworthy SJ, Burton C, Guilherme S. Parotid duct foreign body in a dog diagnosed with CT. J Am Anim Hosp Assoc. 2013; 49(4):250\u2013254. doi:10.5326\/JAAHA-MS-5810"},{"issue":"4","key":"ref8","series-title":"J Am Vet Med Assoc","first-page":"413","article-title":"Ultrasonographic findings and outcomes of dogs with suspected migrating intrathoracic grass awns: 43 cases (2010\u20132013)","volume":"248","author":"Caivano D","year":"2016","unstructured":"Caivano D, Birettoni F, Rishniw M,  Ultrasonographic findings and outcomes of dogs with suspected migrating intrathoracic grass awns: 43 cases (2010\u20132013). J Am Vet Med Assoc. 2016; 248(4):413\u2013421. doi:10.2460\/javma.248.4.41326829274"},{"issue":"3","key":"ref9","series-title":"Otolaryngol Clin North Am","first-page":"459","article-title":"Deep neck infection","volume":"41","author":"Vieira F","year":"2008","unstructured":"Vieira F, Allen SM, Stocks RM, Thompson JW. Deep neck infection. Otolaryngol Clin North Am. 2008; 41(3):459\u2013483. doi:10.1016\/j.otc.2008.01.00218435993"},{"key":"ref10","series-title":"Int J Surg","first-page":"131","article-title":"A clinical prediction score to determine surgical drainage of deep neck infection: a retrospective case-control study","volume":"52","author":"Ban MJ","year":"2018","unstructured":"Ban MJ, Jung JY, Kim JW,  A clinical prediction score to determine surgical drainage of deep neck infection: a retrospective case-control study. Int J Surg. 2018;52:131\u2013135. doi:10.1016\/j.ijsu.2018.02.02429455048"},{"issue":"2","key":"ref11","series-title":"Br J Oral Maxillofac Surg","first-page":"228","article-title":"Neutrophil to lymphocyte ratio as a prognostic marker of deep neck space infections secondary to odontogenic infection","volume":"59","author":"Gallagher N","year":"2021","unstructured":"Gallagher N, Collyer J, Bowe CM. Neutrophil to lymphocyte ratio as a prognostic marker of deep neck space infections secondary to odontogenic infection. Br J Oral Maxillofac Surg. 2021; 59(2):228\u2013232. doi:10.1016\/j.bjoms.2020.08.07533229061"},{"issue":"10","key":"ref12","series-title":"Acta Otolaryngol","first-page":"1191","article-title":"Deep neck space infections remain a surgical challenge. A study of 72 patients","volume":"124","author":"Stalfors J","year":"2004","unstructured":"Stalfors J, Adielsson A, Ebenfelt A, Nethander G, Westin T. Deep neck space infections remain a surgical challenge. A study of 72 patients. Acta Otolaryngol. 2004; 124(10):1191\u20131196. doi:10.1080\/0001648041001786415768817"},{"issue":"4","key":"ref13","series-title":"Am J Otolaryngol","first-page":"559","article-title":"Deep neck infections originating from the major salivary glands","volume":"36","author":"Favaretto N","year":"2015","unstructured":"Favaretto N, Fasanaro E, Staffieri A,  Deep neck infections originating from the major salivary glands. Am J Otolaryngol. 2015; 36(4):559\u2013564. doi:10.1016\/j.amjoto.2015.01.00325630849"},{"issue":"5","key":"ref14","series-title":"Anesth Analg","first-page":"1763","article-title":"Correlation coefficients: appropriate use and interpretation","volume":"126","author":"Schober P","year":"2018","unstructured":"Schober P, Boer C, Schwarte LA. Correlation coefficients: appropriate use and interpretation. Anesth Analg. 2018; 126(5):1763\u20131768. doi:10.1213\/ANE.000000000000286429481436"},{"issue":"6","key":"ref15","series-title":"Otolaryngol Clin North Am","first-page":"1203","article-title":"Imaging anatomy of deep neck spaces","volume":"45","author":"Warshafsky D","year":"2012","unstructured":"Warshafsky D, Goldenberg D, Kanekar SG. Imaging anatomy of deep neck spaces. Otolaryngol Clin North Am. 2012; 45(6):1203\u20131221. doi:10.1016\/j.otc.2012.08.00123153745"},{"issue":"6","key":"ref16","series-title":"Med Clin North Am","first-page":"1109","article-title":"Urgent infections of the head and neck","volume":"102","author":"Russell MD","year":"2018","unstructured":"Russell MD, Russell MS. Urgent infections of the head and neck. Med Clin North Am. 2018; 102(6):1109\u20131120. doi:10.1016\/j.mcna.2018.06.01530342612"},{"issue":"1","key":"ref17","series-title":"Clin Otolaryngol","first-page":"156","article-title":"Controversies in the management of deep neck space infection in children: an evidence-based review","volume":"42","author":"Lawrence R","year":"2017","unstructured":"Lawrence R, Bateman N. Controversies in the management of deep neck space infection in children: an evidence-based review. Clin Otolaryngol. 2017; 42(1):156\u2013163. doi:10.1111\/coa.1269227288654"},{"issue":"1","key":"ref18","series-title":"ORL J Otorhinolaryngol Relat Spec","first-page":"37","article-title":"Parapharyngeal abscess: comprehensive management protocol","volume":"69","author":"Oh JH","year":"2007","unstructured":"Oh JH, Kim Y, Kim CH. Parapharyngeal abscess: comprehensive management protocol. ORL J Otorhinolaryngol Relat Spec. 2007; 69(1):37\u201342. doi:10.1159\/00009671517085951"},{"issue":"1","key":"ref19","series-title":"Pediatr Infect Dis J","first-page":"14","article-title":"Nonsurgical management of deep neck infections in children","volume":"11","author":"Broughton RA","year":"1992","unstructured":"Broughton RA. Nonsurgical management of deep neck infections in children. Pediatr Infect Dis J. 1992; 11(1):14\u201318. doi:10.1097\/00006454-199201000-000051549402"},{"issue":"8","key":"ref20","series-title":"Laryngoscope","first-page":"1413","article-title":"Surgical management of retropharyngeal space infections in children","volume":"111","author":"Kirse DJ","year":"2001","unstructured":"Kirse DJ, Roberson DW. Surgical management of retropharyngeal space infections in children. Laryngoscope. 2001; 111(8):1413\u20131422. doi:10.1097\/00005537-200108000-0001811568578"},{"key":"ref21","series-title":"Miller\u2019s Anatomy of the Dog","first-page":"185","article-title":"The muscular system","author":"Hermanson JW","year":"2013","unstructured":"Hermanson JW. The muscular system. In: Evans HE, de Lahunta A. Miller\u2019s Anatomy of the Dog. 4th ed. Elsevier Saunders; 2013:185\u2013280."},{"issue":"6","key":"ref22","series-title":"Otolaryngol Head Neck Surg","first-page":"746","article-title":"Comparison of computed tomography and surgical findings in deep neck infections","volume":"111","author":"Lazor JB","year":"1994","unstructured":"Lazor JB, Cunningham MJ, Eavey RD, Weber AL. Comparison of computed tomography and surgical findings in deep neck infections. Otolaryngol Head Neck Surg. 1994; 111(6):746\u2013750. doi:10.1177\/0194599894111006087991254"},{"issue":"11","key":"ref23","series-title":"Laryngoscope","first-page":"1873","article-title":"A prospective, blinded comparison of clinical examination and computed tomography in deep neck infections","volume":"109","author":"Miller WD","year":"1999","unstructured":"Miller WD, Furst IM, S\u00e0ndor GK, Keller MA. A prospective, blinded comparison of clinical examination and computed tomography in deep neck infections. Laryngoscope. 1999; 109(11):1873\u20131879. doi:10.1097\/00005537-199911000-0002910569425"},{"issue":"1","key":"ref24","series-title":"Vet Clin Pathol","first-page":"45","article-title":"Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in dogs and cats with acute pancreatitis","volume":"50","author":"Neumann S","year":"2021","unstructured":"Neumann S. Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in dogs and cats with acute pancreatitis. Vet Clin Pathol. 2021; 50(1):45\u201351. doi:10.1111\/vcp.1297933759228"},{"issue":"6","key":"ref25","series-title":"J Am Anim Hosp Assoc","first-page":"351","article-title":"Utility and prognostic significance of neutrophil-to-lymphocyte ratio in dogs with septic peritonitis","volume":"54","author":"Hodgson N","year":"2018","unstructured":"Hodgson N, Llewellyn EA, Schaeffer DJ. Utility and prognostic significance of neutrophil-to-lymphocyte ratio in dogs with septic peritonitis. 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