{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:02:58Z","timestamp":1791050578775,"version":"4.1.0"},"reference-count":40,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2023,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>The geographical distribution of feline cytauxzoonosis is expanding in the US. Clinical signs of feline cytauxzoonosis, including lethargy, anorexia, and icterus, are similar to hepatic lipidosis and cholangiohepatitis. Hematologic and serum biochemical abnormality patterns may assist practitioners in prioritizing feline cytauxzoonosis as a differential diagnosis over hepatic lipidosis and cholangiohepatitis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>SAMPLE<\/jats:title>\n<jats:p>Hematology and serum biochemical profiles of cats with naturally acquired feline cytauxzoonosis, hepatic lipidosis, or cholangiohepatitis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>PROCEDURES<\/jats:title>\n<jats:p>Retrospective search and analysis of the Kansas State Veterinary Diagnostic Laboratory or Kansas State University Veterinary Health Center records between January 2007 and June 2018 for cats with cytauxzoonosis, hepatic lipidosis, or cholangiohepatitis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Patients with acute feline cytauxzoonosis presented with frequent nonregenerative anemia (20\/28 [71%]), leukopenia (23\/28 [82%]), thrombocytopenia (23\/23 [100%]), hyperbilirubinemia (27\/28 [97%]), hypoalbuminemia (26\/28 [93%]), reduced (18\/28 [64%]) or low normal (10\/28 [36%]) serum ALP activity, and hyponatremia (23\/28 [82%]). Reduced ALP activity was unique to cats with feline cytauxzoonosis relative to hepatic lipidosis and cholangiohepatitis. No correlation between the severity of anemia and the magnitude of hyperbilirubinemia was identified in feline cytauxzoonosis patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>The combination of nonregenerative anemia, leukopenia, thrombocytopenia, hyperbilirubinemia, and reduced serum ALP activity in icteric cats may increase the clinical suspicion, but is not pathognomonic, for acute feline cytauxzoonosis. Hematologic and serum biochemical abnormalities of naturally acquired feline cytauxzoonosis are like those reported with feline bacterial sepsis. Blood smear evaluation for intraerythrocytic <jats:italic>Cytauxzoon felis<\/jats:italic> piroplasms, tissue aspirates for schizont-laden macrophages, and\/or molecular testing are required to diagnose feline cytauxzoonosis.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.22.05.0207","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T14:28:38Z","timestamp":1674138518000},"page":"517-525","source":"Crossref","is-referenced-by-count":1,"title":["Serum biochemical changes in cats with naturally acquired feline cytauxzoonosis"],"prefix":"10.2460","volume":"261","author":[{"given":"Brandy C.","family":"Kastl","sequence":"first","affiliation":[{"name":"Kansas State Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Kansas State University, Manhattan, KS"},{"name":"Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora L.","family":"Springer","sequence":"additional","affiliation":[{"name":"Kansas State Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Kansas State University, Manhattan, KS"},{"name":"Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"1","key":"ref1","series-title":"Vet Clin North Am Small Anim Pract","first-page":"89","article-title":"Feline cytauxzoonosis","volume":"35","author":"Meinkoth JH","year":"2005","unstructured":"Meinkoth JH, Kocan AA. 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