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Dogs with heart disease secondary to MMVD experience patterns of metabolic changes that include decreased mitochondrial energy metabolism and ATP availability, with increased oxidative stress and inflammation. These changes occur early in disease and progress with worsening heart disease. Key nutrients that may support normal function and address these changes include omega-3 fatty acids, medium-chain triglycerides, magnesium, antioxidants including vitamin E and taurine, and the amino acids methionine and lysine. The long-chain omega-3 fatty acids provide anti-inflammatory, antithrombotic, and other benefits. Medium-chain fatty acids and ketones derived from medium-chain triglycerides provide an alternative energy source for cardiac mitochondria and help reduce free radical production. Magnesium supports mitochondrial function, normal cardiac rhythm, and provides other benefits. Both vitamin E and taurine counter oxidative stress, and taurine also has direct cardiac benefits. Dogs with MMVD have reduced plasma methionine. Methionine and lysine are important for carnitine production as well as other functions. This article reviews the evidence supporting the functions and benefits of these and other nutrients in MMVD and other cardiac conditions.<\/jats:p>","DOI":"10.2460\/javma.22.07.0319","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T13:15:16Z","timestamp":1664802916000},"page":"S61-S70","source":"Crossref","is-referenced-by-count":7,"title":["Key nutrients important in the management of canine myxomatous mitral valve disease and heart failure"],"prefix":"10.2460","volume":"260","author":[{"given":"Dorothy P.","family":"Laflamme","sequence":"first","affiliation":[{"name":"Veterinary Nutrition Communications, Floyd, VA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"3","key":"B1","series-title":"J Vet Intern Med","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1111\/jvim.15488","article-title":"ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs","volume":"33","author":"Keene BW","year":"2019","unstructured":"Keene BW, Atkins CE, Bonagura JD, et al. 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