{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T21:16:52Z","timestamp":1793654212236,"version":"4.5.1"},"reference-count":70,"publisher":"American Veterinary Medical Association (AVMA)","issue":"15","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>In this article, which is part of the Currents in One Health series, the role of naturally occurring ocular disease in animals is reviewed with emphasis on how the understanding of these ocular diseases contributes to one health initiatives, particularly the pathogenesis and treatment of ocular diseases common to animals and humans. Animals spontaneously develop ocular diseases that closely mimic those in humans, especially dry eye disease, herpes virus infection (cats), fungal keratitis (horses), bacterial keratoconjunctivitis, uveitis, and glaucoma. Both uveitis and glaucoma are common in domestic animals and humans, and many similarities exist in pathogenesis, genetics, and response to therapy. Furthermore, the study of inherited retinal disease in animals has particularly epitomized the one health concept, specifically the collaborative efforts of multiple disciplines working to attain optimal health for people and animals. Through this study of retinal disease in dogs, innovative therapies such as gene therapy have been developed. A unique opportunity exists to study ocular disease in shared environments to better understand the interplay between the environment, genetics, and ocular disease in both animals and humans. The companion Currents in One Health by Gilger, <jats:italic>AJVR<\/jats:italic>, December 2022, addresses in more detail recent studies of noninfectious immune-mediated animal ocular disease and their role in advancing ocular health globally.<\/jats:p>","DOI":"10.2460\/javma.22.08.0383","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T12:41:43Z","timestamp":1664973703000},"page":"1887-1893","source":"Crossref","is-referenced-by-count":3,"title":["How study of naturally occurring ocular disease in animals improves ocular health globally"],"prefix":"10.2460","volume":"260","author":[{"given":"Brian C.","family":"Gilger","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"12","key":"ref1","series-title":"Emerg Infect Dis","first-page":"1913","article-title":"Review of Institute of Medicine and National Research Council recommendations for one health initiative","volume":"19","author":"Rubin C","year":"2013","unstructured":"Rubin C, Myers T, Stokes W,  Review of Institute of Medicine and National Research Council recommendations for one health initiative. Emerg Infect Dis. 2013;19(12):1913\u20131917. doi:10.3201\/eid1912.12165924274461"},{"issue":"2","key":"ref2","series-title":"J Am Vet Med Assoc","first-page":"259","article-title":"Executive summary of the AVMA One Health Initiative Task Force report","volume":"233","author":"King LJ","year":"2008","unstructured":"King LJ, Anderson LR, Blackmore CG,  Executive summary of the AVMA One Health Initiative Task Force report. J Am Vet Med Assoc. 2008;233(2):259\u2013261. doi:10.2460\/javma.233.2.25918627228"},{"key":"ref3","series-title":"One health","unstructured":"CDC. One health. Reviewed September 13, 2022. Accessed September 16, 2022. https:\/\/www.cdc.gov\/onehealth\/"},{"issue":"3","key":"ref4","series-title":"J Ocul Pharmacol Ther","first-page":"137","article-title":"The immunological basis of dry eye disease and current topical treatment options","volume":"36","author":"Periman LM","year":"2020","unstructured":"Periman LM, Perez VL, Saban DR, Lin MC, Neri P. The immunological basis of dry eye disease and current topical treatment options. J Ocul Pharmacol Ther. 2020;36(3):137\u2013146. doi:10.1089\/jop.2019.006032175799"},{"issue":"8","key":"ref5","series-title":"J Small Anim Pract","first-page":"636","article-title":"Keratoconjunctivitis sicca in dogs under primary veterinary care in the UK: an epidemiological study","volume":"62","author":"O\u2019Neill DG","year":"2021","unstructured":"O\u2019Neill DG, Brodbelt DC, Keddy A, Church DB, Sanchez RF. Keratoconjunctivitis sicca in dogs under primary veterinary care in the UK: an epidemiological study. J Small Anim Pract. 2021;62(8):636\u2013645. doi:10.1111\/jsap.1338234134171"},{"key":"ref6","series-title":"Am J Ophthalmol","first-page":"47","article-title":"Estimated prevalence and incidence of dry eye disease based on coding analysis of a large, all-age United States health care system","volume":"202","author":"Dana R","year":"2019","unstructured":"Dana R, Bradley JL, Guerin A,  Estimated prevalence and incidence of dry eye disease based on coding analysis of a large, all-age United States health care system. Am J Ophthalmol. 2019;202:47\u201354. doi:10.1016\/j.ajo.2019.01.02630721689"},{"issue":"3","key":"ref7","series-title":"ILAR J","first-page":"352","article-title":"Immune relevant models for ocular inflammatory diseases","volume":"59","author":"Gilger BC","year":"2018","unstructured":"Gilger BC. Immune relevant models for ocular inflammatory diseases. ILAR J. 2018;59(3):352\u2013362. doi:10.1093\/ilar\/ily00229474707"},{"issue":"12","key":"ref8","series-title":"Cornea","first-page":"1568","article-title":"Comprehensive clinical, diagnostic, and advanced imaging characterization of the ocular surface in spontaneous aqueous deficient dry eye disease in dogs","volume":"38","author":"Leonard BC","year":"2019","unstructured":"Leonard BC, Stewart KA, Shaw GC,  Comprehensive clinical, diagnostic, and advanced imaging characterization of the ocular surface in spontaneous aqueous deficient dry eye disease in dogs. Cornea. 2019;38(12):1568\u20131575. doi:10.1097\/ICO.0000000000002081"},{"issue":"8","key":"ref9","series-title":"Arch Ophthalmol","first-page":"1210","article-title":"Spontaneous canine keratoconjunctivitis sicca. A useful model for human keratoconjunctivitis sicca: treatment with cyclosporine eye drops","volume":"107","author":"Kaswan RL","year":"1989","unstructured":"Kaswan RL, Salisbury M-A, Ward DA. Spontaneous canine keratoconjunctivitis sicca. A useful model for human keratoconjunctivitis sicca: treatment with cyclosporine eye drops. Arch Ophthalmol. 1989;107(8):1210\u20131216. doi:10.1001\/archopht.1989.010700202760382757551"},{"issue":"1","key":"ref10","series-title":"Ophthalmology","first-page":"76","article-title":"Long-term resolution of chronic dry eye symptoms and signs after topical cyclosporine treatment","volume":"114","author":"Wilson SE","year":"2007","unstructured":"Wilson SE, Perry HD. Long-term resolution of chronic dry eye symptoms and signs after topical cyclosporine treatment. Ophthalmology. 2007;114(1):76\u201379. doi:10.1016\/j.ophtha.2006.05.07717070588"},{"issue":"6","key":"ref11","series-title":"Invest Ophthalmol Vis Sci","first-page":"3174","article-title":"The pharmacologic assessment of a novel lymphocyte function-associated antigen-1 antagonist (SAR 1118) for the treatment of keratoconjunctivitis sicca in dogs","volume":"52","author":"Murphy CJ","year":"2011","unstructured":"Murphy CJ, Bentley E, Miller PE,  The pharmacologic assessment of a novel lymphocyte function-associated antigen-1 antagonist (SAR 1118) for the treatment of keratoconjunctivitis sicca in dogs. Invest Ophthalmol Vis Sci. 2011;52(6):3174\u20133180. doi:10.1167\/iovs.09-507821330663"},{"issue":"11","key":"ref12","series-title":"Am J Vet Res","first-page":"903","article-title":"In vivo confocal microscopic features of naturally acquired canine herpesvirus-1 and feline herpesvirus-1 dendritic and punctate ulcerative keratitis","volume":"82","author":"Ledbetter EC","year":"2021","unstructured":"Ledbetter EC, Joslin AR, Spertus CB, Badanes Z, Mohammed HO. In vivo confocal microscopic features of naturally acquired canine herpesvirus-1 and feline herpesvirus-1 dendritic and punctate ulcerative keratitis. Am J Vet Res. 2021;82(11):903\u2013911. doi:10.2460\/ajvr.82.11.90334669494"},{"issue":"3","key":"ref13","series-title":"PLoS One","first-page":"e0214214","article-title":"Multi-locus DNA sequence analysis, antifungal agent susceptibility, and fungal keratitis outcome in horses from Southeastern United States","volume":"14","author":"Cullen M","year":"2019","unstructured":"Cullen M, Jacob ME, Cornish V,  Multi-locus DNA sequence analysis, antifungal agent susceptibility, and fungal keratitis outcome in horses from Southeastern United States. PLoS One. 2019;14(3):e0214214. doi:10.1371\/journal.pone.021421430921394"},{"key":"ref14","series-title":"Front Vet Sci","first-page":"583965","article-title":"Prevalence and antibiotic susceptibility of bacterial isolates from dogs with ulcerative keratitis in Midwestern United States","volume":"7","author":"Hewitt JS","year":"2020","unstructured":"Hewitt JS, Allbaugh RA, Kenne DE, Sebbag L. Prevalence and antibiotic susceptibility of bacterial isolates from dogs with ulcerative keratitis in Midwestern United States. Front Vet Sci. 2020;7:583965. doi:10.3389\/fvets.2020.58396533330707"},{"issue":"5","key":"ref15","series-title":"J Ocul Pharmacol Ther","first-page":"339","article-title":"Comparative efficacy of topical ophthalmic ganciclovir and oral famciclovir in cats with experimental ocular feline herpesvirus-1 epithelial infection","volume":"38","author":"Ledbetter EC","year":"2022","unstructured":"Ledbetter EC, Badanes ZI, Chan RX,  Comparative efficacy of topical ophthalmic ganciclovir and oral famciclovir in cats with experimental ocular feline herpesvirus-1 epithelial infection. J Ocul Pharmacol Ther. 2022;38(5):339\u2013347. doi:10.1089\/jop.2022.000135613418"},{"issue":"5","key":"ref16","series-title":"Vet Ophthalmol","first-page":"918","article-title":"In vitro susceptibility of Aspergillus and Fusarium associated with equine keratitis to new antifungal drugs","volume":"23","author":"Roberts D","year":"2020","unstructured":"Roberts D, Cotter HVT, Cubeta M, Gilger BC. In vitro susceptibility of Aspergillus and Fusarium associated with equine keratitis to new antifungal drugs. Vet Ophthalmol. 2020;23(5):918\u2013922. doi:10.1111\/vop.1277432418311"},{"key":"ref17","series-title":"Vet Ophthalmol","article-title":"In vitro susceptibility of canine corneal bacterial pathogens to three cross-linking protocols","author":"Large TP","unstructured":"Large TP, Mack S, Villiers E, Oliver J. In vitro susceptibility of canine corneal bacterial pathogens to three cross-linking protocols. Vet Ophthalmol. Published online June 17, 2022. doi:10.1111\/vop.1300635713165"},{"issue":"6","key":"ref18","series-title":"Vet Ophthalmol","first-page":"622","article-title":"Treatment of spontaneous chronic corneal epithelial defects (SCCEDs) with diamond burr debridement vs combination diamond burr debridement and superficial grid keratotomy","volume":"21","author":"Wu D","year":"2018","unstructured":"Wu D, Smith SM, Stine JM,  Treatment of spontaneous chronic corneal epithelial defects (SCCEDs) with diamond burr debridement vs combination diamond burr debridement and superficial grid keratotomy. Vet Ophthalmol. 2018;21(6):622\u2013631. doi:10.1111\/vop.1255629536611"},{"key":"ref19","series-title":"Clin Ophthalmol","first-page":"325","article-title":"Recurrent corneal erosion: a comprehensive review","volume":"13","author":"Miller DD","year":"2019","unstructured":"Miller DD, Hasan SA, Simmons NL, Stewart MW. Recurrent corneal erosion: a comprehensive review. Clin Ophthalmol. 2019;13:325\u2013335. doi:10.2147\/OPTH.S15743030809089"},{"issue":"1","key":"ref20","series-title":"BMC Vet Res","first-page":"254","article-title":"A defect in the NOG gene increases susceptibility to spontaneous superficial chronic corneal epithelial defects (SCCED) in Boxer dogs","volume":"17","author":"Meurs KM","year":"2021","unstructured":"Meurs KM, Montgomery K, Friedenberg SG, Williams B, Gilger BC. A defect in the NOG gene increases susceptibility to spontaneous superficial chronic corneal epithelial defects (SCCED) in Boxer dogs. BMC Vet Res. 2021;17(1):254. doi:10.1186\/s12917-021-02955-134311726"},{"key":"ref21","series-title":"Albert and Jakobiec\u2019s Principles and Practice of Ophthalmology","first-page":"331","article-title":"Corneal wound healing, recurrent corneal erosions, and persistent epithelial defects. In:","author":"Paley GL","year":"2022","unstructured":"Paley GL, Wagoner MD, Afshari NA,  Corneal wound healing, recurrent corneal erosions, and persistent epithelial defects. In: Albert and Jakobiec\u2019s Principles and Practice of Ophthalmology. Springer; 2022:331\u2013360. doi:10.1007\/978-3-030-42634-7_212"},{"issue":"10","key":"ref22","series-title":"Invest Ophthalmol Vis Sci","first-page":"2252","article-title":"Spontaneous chronic corneal epithelial defects (SCCED) in dogs: clinical features, innervation, and effect of topical SP, with or without IGF-1","volume":"42","author":"Murphy CJ","year":"2001","unstructured":"Murphy CJ, Marfurt CF, McDermott A,  Spontaneous chronic corneal epithelial defects (SCCED) in dogs: clinical features, innervation, and effect of topical SP, with or without IGF-1. Invest Ophthalmol Vis Sci. 2001;42(10):2252\u20132261."},{"issue":"10","key":"ref23","series-title":"Invest Ophthalmol Vis Sci","first-page":"2262","article-title":"Morphology and immunohistochemistry of spontaneous chronic corneal epithelial defects (SCCED) in dogs","volume":"42","author":"Bentley E","year":"2001","unstructured":"Bentley E, Abrams GA, Covitz D,  Morphology and immunohistochemistry of spontaneous chronic corneal epithelial defects (SCCED) in dogs. Invest Ophthalmol Vis Sci. 2001;42(10):2262\u20132269.11527939"},{"issue":"9","key":"ref24","series-title":"Invest Ophthalmol Vis Sci","first-page":"OCT495","article-title":"In vivo imaging of corneal endothelial dystrophy in Boston Terriers: a spontaneous, canine model for Fuchs\u2019 endothelial corneal dystrophy","volume":"57","author":"Thomasy SM","year":"2016","unstructured":"Thomasy SM, Cortes DE, Hoehn AL, Calderon AC, Li JY, Murphy CJ. In vivo imaging of corneal endothelial dystrophy in Boston Terriers: a spontaneous, canine model for Fuchs\u2019 endothelial corneal dystrophy. Invest Ophthalmol Vis Sci. 2016;57(9):OCT495\u2013OCT503. doi:10.1167\/iovs.15-1888527454658"},{"issue":"7","key":"ref25","series-title":"Invest Ophthalmol Vis Sci","first-page":"2748","article-title":"Topical netarsudil for the treatment of canine corneal endothelial degeneration","volume":"63","author":"Casanova MI","year":"2022","unstructured":"Casanova MI, Echeverria N, Bowman MA,  Topical netarsudil for the treatment of canine corneal endothelial degeneration. Invest Ophthalmol Vis Sci. 2022;63(7):2748-A0237. 2022 ARVO Annual Meeting abstract."},{"issue":"5","key":"ref26","series-title":"Cornea","first-page":"578","article-title":"A retrospective study of corneal endothelial dystrophy in dogs (1991\u20132014)","volume":"40","author":"Leonard BC","year":"2021","unstructured":"Leonard BC, Kermanian CS, Michalak SR,  A retrospective study of corneal endothelial dystrophy in dogs (1991\u20132014). Cornea. 2021;40(5):578\u2013583. doi:10.1097\/ICO.000000000000248832947393"},{"issue":"5","key":"ref27","series-title":"J Inherit Metab Dis","first-page":"489","article-title":"A model of mucopolysaccharidosis IIIB (Sanfilippo syndrome type IIIB): N-acetyl-\u03b1-D-glucosaminidase deficiency in Schipperke dogs","volume":"26","author":"Ellinwood NM","year":"2003","unstructured":"Ellinwood NM, Wang P, Skeen T,  A model of mucopolysaccharidosis IIIB (Sanfilippo syndrome type IIIB): N-acetyl-\u03b1-D-glucosaminidase deficiency in Schipperke dogs. J Inherit Metab Dis. 2003;26(5):489\u2013504. doi:10.1023\/a:1025177411938"},{"issue":"2","key":"ref28","series-title":"Genomics","first-page":"150","article-title":"Identification of a mutation causing mucopolysaccharidosis type IIIA in New Zealand Huntaway dogs","volume":"79","author":"Yogalingam G","year":"2002","unstructured":"Yogalingam G, Pollard T, Gliddon B, Jolly RD, Hopwood JJ. Identification of a mutation causing mucopolysaccharidosis type IIIA in New Zealand Huntaway dogs. Genomics. 2002;79(2):150\u2013153. doi:10.1006\/geno.2002.669911829484"},{"issue":"3","key":"ref29","series-title":"Am J Pathol","first-page":"487","article-title":"Morphologic and biochemical studies of canine mucopolysaccharidosis I","volume":"114","author":"Shull RM","year":"1984","unstructured":"Shull RM, Helman RG, Spellacy E, Constantopoulos G, Munger RJ, Neufeld EF. Morphologic and biochemical studies of canine mucopolysaccharidosis I. Am J Pathol. 1984;114(3):487\u2013495.6320652"},{"issue":"1","key":"ref30","series-title":"Am J Pathol","first-page":"27","article-title":"The pathology of the feline model of mucopolysaccharidosis I","volume":"112","author":"Haskins ME","year":"1983","unstructured":"Haskins ME, Aguirre GD, Jezyk PF, Desnick RJ, Patterson DF. The pathology of the feline model of mucopolysaccharidosis I. Am J Pathol. 1983;112(1):27\u201336.6407329"},{"issue":"3","key":"ref31","series-title":"Am J Pathol","first-page":"657","article-title":"The pathology of the feline model of mucopolysaccharidosis VI","volume":"101","author":"Haskins ME","year":"1980","unstructured":"Haskins ME, Aguirre GD, Jezyk PF, Patterson DF. The pathology of the feline model of mucopolysaccharidosis VI. Am J Pathol. 1980;101(3):657\u2013674.6778219"},{"issue":"8","key":"ref32","series-title":"Invest Ophthalmol Vis Sci","first-page":"5130","article-title":"Ocular lesions in canine mucopolysaccharidosis I and response to enzyme replacement therapy","volume":"52","author":"Newkirk KM","year":"2011","unstructured":"Newkirk KM, Atkins RM, Dickson PI, Rohrbach BW, McEntee MF. Ocular lesions in canine mucopolysaccharidosis I and response to enzyme replacement therapy. Invest Ophthalmol Vis Sci. 2011;52(8):5130\u20135135. doi:10.1167\/iovs.10-675121436264"},{"issue":"8","key":"ref33","series-title":"Invest Ophthalmol Vis Sci","first-page":"991","article-title":"Feline mucopolysaccharidosis VI: general ocular and pigment epithelial pathology","volume":"24","author":"Aguirre G","year":"1983","unstructured":"Aguirre G, Stramm L, Haskins M. Feline mucopolysaccharidosis VI: general ocular and pigment epithelial pathology. Invest Ophthalmol Vis Sci. 1983;24(8):991\u20131007.6409835"},{"issue":"6","key":"ref34","series-title":"Mol Ther","first-page":"1455","article-title":"Intrastromal gene therapy prevents and reverses advanced corneal clouding in a canine model of mucopolysaccharidosis I","volume":"28","author":"Miyadera K","year":"2020","unstructured":"Miyadera K, Conatser L, Llanga TA,  Intrastromal gene therapy prevents and reverses advanced corneal clouding in a canine model of mucopolysaccharidosis I. Mol Ther. 2020;28(6):1455\u20131463. doi:10.1016\/j.ymthe.2020.04.004"},{"issue":"8","key":"ref35","series-title":"Invest Ophthalmol Vis Sci","first-page":"801","article-title":"Intracorneal sequential dosing of AAV-ArsB clears corneal opacity associated with mucopolysaccharidosis VI in a feline model","volume":"62","author":"Gilger BC","year":"2021","unstructured":"Gilger BC, Salmon JH, Roberts D, Song L, Bower J, Hirsch M. Intracorneal sequential dosing of AAV-ArsB clears corneal opacity associated with mucopolysaccharidosis VI in a feline model. Invest Ophthalmol Vis Sci. 2021;62(8):801. 2021 ARVO Annual Meeting abstract."},{"issue":"3","key":"ref36","series-title":"Lancet Infect Dis","first-page":"e49","article-title":"The global incidence and diagnosis of fungal keratitis","volume":"21","author":"Brown L","year":"2021","unstructured":"Brown L, Leck AK, Gichangi M, Burton MJ, Denning DW. The global incidence and diagnosis of fungal keratitis. Lancet Infect Dis. 2021;21(3):e49\u2013e57. doi:10.1016\/S1473-3099(20)30448-533645500"},{"issue":"2","key":"ref37","series-title":"Cornea","first-page":"238","article-title":"Efficacy of luliconazole against broad-range filamentous fungi including Fusarium solani species complex causing fungal keratitis","volume":"38","author":"Todokoro D","year":"2019","unstructured":"Todokoro D, Suzuki T, Tamura T,  Efficacy of luliconazole against broad-range filamentous fungi including Fusarium solani species complex causing fungal keratitis. Cornea. 2019;38(2):238\u2013242. doi:10.1097\/ICO.000000000000181230422866"},{"issue":"12","key":"ref38","series-title":"Pharmaceutics","first-page":"2011","article-title":"Recent advances in photodynamic therapy against fungal keratitis","volume":"13","author":"Hung J-H","year":"2021","unstructured":"Hung J-H, Lee C-N, Hsu H-W,  Recent advances in photodynamic therapy against fungal keratitis. Pharmaceutics. 2021;13(12):2011. doi:10.3390\/pharmaceutics1312201134959293"},{"issue":"3\u20134","key":"ref39","series-title":"Ophthalmic Res","first-page":"151","article-title":"Equine recurrent uveitis\u2014a spontaneous horse model of uveitis","volume":"40","author":"Deeg CA","year":"2008","unstructured":"Deeg CA, Hauck SM, Amann B,  Equine recurrent uveitis\u2014a spontaneous horse model of uveitis. Ophthalmic Res. 2008;40(3\u20134):151\u2013153. doi:10.1159\/00011986718421230"},{"issue":"1","key":"ref40","series-title":"Vet J","first-page":"22","article-title":"Equine recurrent uveitis: human and equine perspectives","volume":"206","author":"Malalana F","year":"2015","unstructured":"Malalana F, Stylianides A, McGowan C. Equine recurrent uveitis: human and equine perspectives. Vet J. 2015;206(1):22\u201329. doi:10.1016\/j.tvjl.2015.06.01726188862"},{"key":"ref41","series-title":"Vet Ophthalmol","first-page":"30","article-title":"Causes of endogenous uveitis in cats presented to referral clinics in North Carolina","volume":"19","author":"Jinks MR","year":"2016","unstructured":"Jinks MR, English RV, Gilger BC. Causes of endogenous uveitis in cats presented to referral clinics in North Carolina. Vet Ophthalmol. 2016;19(suppl 1):30\u201337. doi:10.1111\/vop.1232426559384"},{"issue":"2","key":"ref42","series-title":"Vet Ophthalmol","first-page":"93","article-title":"Causes of uveitis in dogs: 102 cases (1989\u20132000)","volume":"5","author":"Massa KL","year":"2002","unstructured":"Massa KL, Gilger BC, Miller TL, Davidson MG. Causes of uveitis in dogs: 102 cases (1989\u20132000). Vet Ophthalmol. 2002;5(2):93\u201398. doi:10.1046\/j.1463-5224.2002.00217.x12071865"},{"issue":"1","key":"ref43","series-title":"Surv Ophthalmol","first-page":"1","article-title":"Vogt-Koyanagi-Harada disease","volume":"62","author":"O\u2019Keefe GAD","year":"2017","unstructured":"O\u2019Keefe GAD, Rao NA. Vogt-Koyanagi-Harada disease. Surv Ophthalmol. 2017;62(1):1\u201325. doi:10.1016\/j.survophthal.2016.05.00227241814"},{"issue":"10","key":"ref44","series-title":"J Am Vet Med Assoc","first-page":"1263","article-title":"Clinical findings and outcomes for dogs with uveodermatologic syndrome","volume":"252","author":"Zarfoss MK","year":"2018","unstructured":"Zarfoss MK, Tusler CA, Kass PH,  Clinical findings and outcomes for dogs with uveodermatologic syndrome. J Am Vet Med Assoc. 2018;252(10):1263\u20131271. doi:10.2460\/javma.252.10.126329701516"},{"issue":"6","key":"ref45","series-title":"Invest Ophthalmol Vis Sci","first-page":"2596","article-title":"A novel bioerodible deep scleral lamellar cyclosporine implant for uveitis","volume":"47","author":"Gilger BC","year":"2006","unstructured":"Gilger BC, Salmon JH, Wilkie DA,  A novel bioerodible deep scleral lamellar cyclosporine implant for uveitis. Invest Ophthalmol Vis Sci. 2006;47(6):2596\u20132605. doi:10.1167\/iovs.05-154016723476"},{"issue":"5","key":"ref46","series-title":"Arch Ophthalmol","first-page":"545","article-title":"Dexamethasone intravitreal implant for noninfectious intermediate or posterior uveitis","volume":"129","author":"Lowder C","year":"2011","unstructured":"Lowder C, Belfort RJr, Lightman S, ; Ozurdex HURON Study Group. Dexamethasone intravitreal implant for noninfectious intermediate or posterior uveitis. Arch Ophthalmol. 2011;129(5):545\u2013553. doi:10.1001\/archophthalmol.2010.339"},{"issue":"1","key":"ref47","series-title":"Sci Rep","first-page":"7177","article-title":"Open label safety and efficacy pilot to study mitigation of equine recurrent uveitis through topical suppressor of cytokine signaling-1 mimetic peptide","volume":"12","author":"Plummer CE","year":"2022","unstructured":"Plummer CE, Polk T, Sharma J,  Open label safety and efficacy pilot to study mitigation of equine recurrent uveitis through topical suppressor of cytokine signaling-1 mimetic peptide. Sci Rep. 2022;12(1):7177. doi:10.1038\/s41598-022-11338-x35505065"},{"issue":"8","key":"ref48","series-title":"Invest Ophthalmol Vis Sci","first-page":"994","article-title":"Prevention of experimental autoimmune uveitis by intravitreal AAV-EqIL-10","volume":"62","author":"Crabtree E","year":"2021","unstructured":"Crabtree E, Gilger BC, Hirsch M,  Prevention of experimental autoimmune uveitis by intravitreal AAV-EqIL-10. Invest Ophthalmol Vis Sci. 2021;62(8):994. 2021 ARVO Annual Meeting abstract."},{"key":"ref49","series-title":"PLoS One","article-title":"Prevention of experimental autoimmune uveitis by intravitreal AAV-EqIL-10","volume":"17","author":"Crabtree E","year":"2022","unstructured":"Crabtree E, Uribe K, Smith S,  Prevention of experimental autoimmune uveitis by intravitreal AAV-EqIL-10. PLoS One. 2022;17:in press."},{"issue":"5","key":"ref50","series-title":"Vet Ophthalmol","first-page":"726","article-title":"The future of canine glaucoma therapy","volume":"22","author":"Kom\u00e1romy AM","year":"2019","unstructured":"Kom\u00e1romy AM, Bras D, Esson DW,  The future of canine glaucoma therapy. Vet Ophthalmol. 2019;22(5):726\u2013740. doi:10.1111\/vop.1267831106969"},{"issue":"4","key":"ref51","series-title":"Vet Ophthalmol","first-page":"316","article-title":"Biomechanics of the optic nerve head and sclera in canine glaucoma: a brief review","volume":"24","author":"Park SA","year":"2021","unstructured":"Park SA, Kom\u00e1romy AM. Biomechanics of the optic nerve head and sclera in canine glaucoma: a brief review. Vet Ophthalmol. 2021;24(4):316\u2013325. doi:10.1111\/vop.1292334402566"},{"issue":"5","key":"ref52","series-title":"Vet Ophthalmol","first-page":"520","article-title":"Proteomic analysis of aqueous humor in canine primary angle-closure glaucoma in American Cocker Spaniel dogs","volume":"24","author":"Yun S","year":"2021","unstructured":"Yun S, Lee D, Kang S,  Proteomic analysis of aqueous humor in canine primary angle-closure glaucoma in American Cocker Spaniel dogs. Vet Ophthalmol. 2021;24(5):520\u2013532. doi:10.1111\/vop.1293734558166"},{"key":"ref53","series-title":"Vet Ophthalmol","first-page":"47","article-title":"Microanatomy of the anterior uveoscleral outflow pathway in normal and primary open-angle glaucomatous dogs","volume":"15","author":"Samuelson D","year":"2012","unstructured":"Samuelson D, Streit A. Microanatomy of the anterior uveoscleral outflow pathway in normal and primary open-angle glaucomatous dogs. Vet Ophthalmol. 2012;15(suppl 1):47\u201353. doi:10.1111\/j.1463-5224.2011.00943.x22050998"},{"issue":"9","key":"ref54","series-title":"Invest Ophthalmol Vis Sci","first-page":"3184","article-title":"Imaging post-trabecular outflow pathways in spontaneous canine glaucoma","volume":"60","author":"McLellan GJ","year":"2019","unstructured":"McLellan GJ, Telle MR, Nilles J,  Imaging post-trabecular outflow pathways in spontaneous canine glaucoma. Invest Ophthalmol Vis Sci. 2019;60(9):3184. 2019 ARVO Annual Meeting abstract."},{"issue":"1","key":"ref55","series-title":"Eye (Lond)","first-page":"29","article-title":"Clinical implications of recent advances in primary open-angle glaucoma genetics","volume":"34","author":"Choquet H","year":"2020","unstructured":"Choquet H, Wiggs JL, Khawaja AP. Clinical implications of recent advances in primary open-angle glaucoma genetics. Eye (Lond). 2020;34(1):29\u201339. doi:10.1038\/s41433-019-0632-731645673"},{"issue":"9","key":"ref56","series-title":"Genes (Basel)","first-page":"1403","article-title":"Glaucoma syndromes: insights into glaucoma genetics and pathogenesis from monogenic syndromic disorders","volume":"12","author":"Balikov DA","year":"2021","unstructured":"Balikov DA, Jacobson A, Prasov L. Glaucoma syndromes: insights into glaucoma genetics and pathogenesis from monogenic syndromic disorders. Genes (Basel). 2021;12(9):1403. doi:10.3390\/genes1209140334573386"},{"issue":"3","key":"ref57","series-title":"G3 (Bethesda)","first-page":"943","article-title":"Arginine to glutamine variant in olfactomedin like 3 (OLFML3) is a candidate for severe goniodysgenesis and glaucoma in the Border Collie dog breed","volume":"9","author":"Pugh CA","year":"2019","unstructured":"Pugh CA, Farrell LL, Carlisle AJ,  Arginine to glutamine variant in olfactomedin like 3 (OLFML3) is a candidate for severe goniodysgenesis and glaucoma in the Border Collie dog breed. G3 (Bethesda). 2019;9(3):943\u2013954. doi:10.1534\/g3.118.20094430696701"},{"issue":"1","key":"ref58","series-title":"Vet Ophthalmol","first-page":"25","article-title":"A variant in OLFML3 is associated with pectinate ligament abnormality and primary closed-angle glaucoma in Border Collies from the United Kingdom","volume":"23","author":"Oliver JAC","year":"2020","unstructured":"Oliver JAC, Wright H, Massidda PA, Burmeister LM, Mellersh CS. A variant in OLFML3 is associated with pectinate ligament abnormality and primary closed-angle glaucoma in Border Collies from the United Kingdom. Vet Ophthalmol. 2020;23(1):25\u201336. doi:10.1111\/vop.1268031141290"},{"key":"ref59","series-title":"Vet Ophthalmol","first-page":"16","article-title":"Looking into the future: gene and cell therapies for glaucoma","volume":"24","author":"Kom\u00e1romy AM","year":"2021","unstructured":"Kom\u00e1romy AM, Koehl KL, Park SA. Looking into the future: gene and cell therapies for glaucoma. Vet Ophthalmol. 2021;24(suppl 1):16\u201333. doi:10.1111\/vop.1285833411993"},{"issue":"4","key":"ref60","series-title":"J Ocul Pharmacol Ther","first-page":"311","article-title":"Intraocular pressure-lowering efficacy of a sustained-release bimatoprost implant in dog eyes pretreated with selective laser trabeculoplasty","volume":"38","author":"Ghosn C","year":"2022","unstructured":"Ghosn C, Rajagopalan L, Ugarte S,  Intraocular pressure-lowering efficacy of a sustained-release bimatoprost implant in dog eyes pretreated with selective laser trabeculoplasty. J Ocul Pharmacol Ther. 2022;38(4):311\u2013318. doi:10.1089\/jop.2021.010435442770"},{"key":"ref61","series-title":"Vet Ophthalmol","first-page":"2","article-title":"Medical anti-glaucoma therapy: beyond the drop","volume":"24","author":"Miller PE","year":"2021","unstructured":"Miller PE, Eaton JS. Medical anti-glaucoma therapy: beyond the drop. Vet Ophthalmol. 2021;24(suppl 1):2\u201315. doi:10.1111\/vop.1284333164328"},{"issue":"3","key":"ref62","series-title":"J Ocul Pharmacol Ther","first-page":"138","article-title":"Dose-response of intracameral bimatoprost sustained-release implant and topical bimatoprost in lowering intraocular pressure","volume":"35","author":"Lee SS","year":"2019","unstructured":"Lee SS, Dibas M, Almazan A, Robinson MR. Dose-response of intracameral bimatoprost sustained-release implant and topical bimatoprost in lowering intraocular pressure. J Ocul Pharmacol Ther. 2019;35(3):138\u2013144. doi:10.1089\/jop.2018.009530698494"},{"issue":"2","key":"ref63","series-title":"Genes (Basel)","first-page":"334","article-title":"FYCO1 frameshift deletion in Wirehaired Pointing Griffon Dogs with juvenile cataract","volume":"13","author":"Rudd Garces G","year":"2022","unstructured":"Rudd Garces G, Christen M, Loechel R, Jagannathan V, Leeb T. FYCO1 frameshift deletion in Wirehaired Pointing Griffon Dogs with juvenile cataract. Genes (Basel). 2022;13(2):334. doi:10.3390\/genes1302033435205377"},{"key":"ref64","series-title":"Prog Retin Eye Res","first-page":"100905","article-title":"Posterior capsule opacification: what\u2019s in the bag?","volume":"82","author":"Wormstone IM","year":"2021","unstructured":"Wormstone IM, Wormstone YM, Smith AJO, Eldred JA. Posterior capsule opacification: what\u2019s in the bag? Prog Retin Eye Res. 2021;82:100905. doi:10.1016\/j.preteyeres.2020.10090532977000"},{"issue":"5","key":"ref65","series-title":"Vet Ophthalmol","first-page":"317","article-title":"Posterior capsular opacification in diabetic and nondiabetic canine patients following cataract surgery","volume":"9","author":"Bras ID","year":"2006","unstructured":"Bras ID, Colitz CM, Saville WJ, Gemensky-Metzler AJ, Wilkie DA. Posterior capsular opacification in diabetic and nondiabetic canine patients following cataract surgery. Vet Ophthalmol. 2006;9(5):317\u2013327. doi:10.1111\/j.1463-5224.2006.00458.x16939460"},{"key":"ref66","series-title":"Exp Eye Res","first-page":"2","article-title":"Experimental models for posterior capsule opacification research","volume":"142","author":"Wormstone IM","year":"2016","unstructured":"Wormstone IM, Eldred JA. Experimental models for posterior capsule opacification research. Exp Eye Res. 2016;142:2\u201312. doi:10.1016\/j.exer.2015.04.02125939555"},{"key":"ref67","series-title":"Mol Vis","first-page":"677","article-title":"Prevention of posterior capsular opacification through cyclooxygenase-2 inhibition","volume":"13","author":"Chandler HL","year":"2007","unstructured":"Chandler HL, Barden CA, Lu P, Kusewitt DF, Colitz CM. Prevention of posterior capsular opacification through cyclooxygenase-2 inhibition. Mol Vis. 2007;13:677\u2013691.17563718"},{"issue":"3","key":"ref68","series-title":"Vet Ophthalmol","first-page":"192","article-title":"The use of canine models of inherited retinal degeneration to test novel therapeutic approaches","volume":"12","author":"Beltran WA","year":"2009","unstructured":"Beltran WA. The use of canine models of inherited retinal degeneration to test novel therapeutic approaches. Vet Ophthalmol. 2009;12(3):192\u2013204. doi:10.1111\/j.1463-5224.2009.00694.x19392879"},{"issue":"6","key":"ref69","series-title":"Mol Ther","first-page":"1072","article-title":"Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness","volume":"12","author":"Acland GM","year":"2005","unstructured":"Acland GM, Aguirre GD, Bennett J,  Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness. Mol Ther. 2005;12(6):1072\u20131082. doi:10.1016\/j.ymthe.2005.08.008"},{"issue":"5","key":"ref70","series-title":"Hum Genet","first-page":"441","article-title":"Natural models for retinitis pigmentosa: progressive retinal atrophy in dog breeds","volume":"138","author":"Bunel M","year":"2019","unstructured":"Bunel M, Chaudieu G, Hamel C,  Natural models for retinitis pigmentosa: progressive retinal atrophy in dog breeds. 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