{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:18:46Z","timestamp":1773029926105,"version":"3.50.1"},"reference-count":50,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To evaluate incidences of pyometra and orthopedic, behavioral, urinary\/reproductive, neoplastic, or atopic disease processes as outcomes for dogs undergoing either a laparoscopic-assisted ovary-sparing spay\/hysterectomy (LapOSS) or a laparoscopic ovariectomy (LapOVE).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>33 client-owned dogs.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>PROCEDURES<\/jats:title>\n<jats:p>Medical records of client-owned dogs presenting between August 2013 and May 2020 for elective LapOSS or LapOVE were reviewed. A multiple-choice client questionnaire was emailed to all clients whose dogs\u2019 complete medical records were available.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>17 of the 33 dogs were in the LapOSS group, and 16 of 33 dogs were in the LapOVE group. Of the 17 dogs undergoing LapOSS, 5 of 17 (29%) underwent an elective OVE at a later date. The mean follow-up time was 4.2 \u00b1 1.8 years for the LapOSS group and 4.3 \u00b1 2.0 years for the LapOVE group. No dogs developed stump pyometra. One LapOSS dog developed mammary tumor, and 2 others developed nonreproductive malignant neoplasia while 2 of the LapOVE dogs developed malignant neoplasia. One of the LapOSS dogs with malignant neoplasia had an ovariectomy prior to development of disease.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Laparoscopic-assisted ovary-sparing spay appears to provide a safe and reliable method of sterilization, with no observable increased risk of pyometra with hysterectomy. Owners must be counseled prior to surgery regarding the consequences of gonadal hormone retention and multiple heat cycles.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.22.12.0539","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T13:43:35Z","timestamp":1682689415000},"page":"1166-1173","source":"Crossref","is-referenced-by-count":2,"title":["Canine laparoscopic-assisted ovary-sparing hysterectomy does not increase risk of stump pyometra"],"prefix":"10.2460","volume":"261","author":[{"given":"Marjorie A.","family":"Owen","sequence":"first","affiliation":[{"name":"Veterinary Teaching Hospital, College of Veterinary Medicine, Washington State University, Pullman, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline G.","family":"Sirr","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital, College of Veterinary Medicine, Washington State University, Pullman, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia D.","family":"Albright","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Tennessee, Knoxville, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boel A.","family":"Fransson","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital, College of Veterinary Medicine, Washington State University, Pullman, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"1","key":"ref1","series-title":"Acta Vet Hung","first-page":"171","article-title":"Spaying-related urinary incontinence and oestrogen therapy in the bitch","volume":"57","author":"Veronesi MC","year":"2009","unstructured":"Veronesi MC, Rota A, Battocchio M, Faustini M, Mollo A. Spaying-related urinary incontinence and oestrogen therapy in the bitch. Acta Vet Hung. 2009;57(1):171\u2013182. doi:10.1556\/AVet.57.2009.1.17"},{"issue":"2","key":"ref2","series-title":"J Vet Intern Med","first-page":"442","article-title":"Urethral sphincter mechanism incompetence in 163 neutered female dogs: diagnosis, treatment, and relationship of weight and age at neuter to development of disease","volume":"31","author":"Byron JK","year":"2017","unstructured":"Byron JK, Taylor KH, Phillips GS, Stahl MS. Urethral sphincter mechanism incompetence in 163 neutered female dogs: diagnosis, treatment, and relationship of weight and age at neuter to development of disease. J Vet Intern Med. 2017;31(2):442\u2013448. doi:10.1111\/jvim.14678"},{"issue":"7","key":"ref3","series-title":"J Am Vet Med Assoc","first-page":"959","article-title":"Evaluation of the prevalence of urinary incontinence in spayed female dogs: 566 cases (2003-2008)","volume":"242","author":"Forsee KM","year":"2013","unstructured":"Forsee KM, Davis GJ, Mouat EE, Salmeri KR, Bastian RP. Evaluation of the prevalence of urinary incontinence in spayed female dogs: 566 cases (2003-2008). J Am Vet Med Assoc. 2013;242(7):959\u2013962. doi:10.2460\/javma.242.7.959"},{"issue":"429","key":"ref4","series-title":"Clin Orthop Relat Res","first-page":"301","article-title":"Canine ovariohysterectomy and orchiectomy increases the prevalence of ACL injury","author":"Slauterbeck JR","year":"2004","unstructured":"Slauterbeck JR, Pankratz K, Xu KT, Bozeman SC, Hardy DM. Canine ovariohysterectomy and orchiectomy increases the prevalence of ACL injury. Clin Orthop Relat Res. 2004;(429):301\u2013305. doi:10.1097\/01.blo.0000146469.08655.e2"},{"issue":"11","key":"ref5","series-title":"J Am Vet Med Assoc","first-page":"1688","article-title":"Risk factors for excessive tibial plateau angle in large-breed dogs with cranial cruciate ligament disease","volume":"231","author":"Duerr FM","year":"2007","unstructured":"Duerr FM, Duncan CG, Savicky RS, Park RD, Egger EL, Palmer RH. Risk factors for excessive tibial plateau angle in large-breed dogs with cranial cruciate ligament disease. J Am Vet Med Assoc. 2007;231(11):1688\u20131691. doi:10.2460\/javma.231.11.1688"},{"issue":"3-4","key":"ref6","series-title":"Appl Anim Behav Sci","first-page":"331","article-title":"The role of gonadal hormones in the occurrence of objectionable behaviours in dogs and cats","volume":"52","author":"Hart BL","year":"1997","unstructured":"Hart BL, Eckstein RA. The role of gonadal hormones in the occurrence of objectionable behaviours in dogs and cats. Appl Anim Behav Sci. 1997;52(3-4):331\u2013344. doi:10.1016\/S0168-1591(96)01133-1"},{"issue":"12","key":"ref7","series-title":"Animals (Basel)","first-page":"1086","article-title":"Desexing dogs: a review of the current literature","volume":"9","author":"Urfer SR","year":"2019","unstructured":"Urfer SR, Kaeberlein M. Desexing dogs: a review of the current literature. Animals (Basel). 2019;9(12):1086. doi:10.3390\/ani9121086."},{"issue":"12","key":"ref8","series-title":"J Am Vet Med Assoc","first-page":"1818","article-title":"Prevalence of and risk factors for hip dysplasia and cranial cruciate ligament deficiency in dogs","volume":"232","author":"Witsberger TH","year":"2008","unstructured":"Witsberger TH, Villamil JA, Schultz LG, Hahn AW, Cook JL. Prevalence of and risk factors for hip dysplasia and cranial cruciate ligament deficiency in dogs. J Am Vet Med Assoc. 2008;232(12):1818\u20131824. doi:10.2460\/javma.232.12.1818"},{"issue":"7","key":"ref9","series-title":"PLoS One","first-page":"e102241","article-title":"Long-term health effects of neutering dogs: comparison of Labrador Retrievers with Golden Retrievers","volume":"9","author":"Hart BL","year":"2014","unstructured":"Hart BL, Hart LA, Thigpen AP, Willits NH. Long-term health effects of neutering dogs: comparison of Labrador Retrievers with Golden Retrievers. PLoS One. 2014;9(7):e102241. doi:10.1371\/journal.pone.0102241"},{"issue":"1","key":"ref10","series-title":"Vet J","first-page":"31","article-title":"Host related risk factors for canine osteosarcoma","volume":"156","author":"Ru G","year":"1998","unstructured":"Ru G, Terracini B, Glickman LT. Host related risk factors for canine osteosarcoma. Vet J. 1998;156(1):31\u201339. doi:10.1016\/s1090-0233(98)80059-2"},{"issue":"11","key":"ref11","series-title":"Cancer Epidemiol Biomarkers Prev","first-page":"1434","article-title":"Endogenous gonadal hormone exposure and bone sarcoma risk","volume":"11","author":"Cooley DM","year":"2002","unstructured":"Cooley DM, Beranek BC, Schlittler DL, Glickman NW, Glickman LT, Waters DJ. Endogenous gonadal hormone exposure and bone sarcoma risk. Cancer Epidemiol Biomarkers Prev. 2002;11(11):1434\u20131440."},{"issue":"2","key":"ref12","series-title":"PLoS One","first-page":"e55937","article-title":"Neutering dogs: effects on joint disorders and cancers in Golden Retrievers","volume":"8","author":"Torres de la Riva G","year":"2013","unstructured":"Torres de la Riva G, Hart BL, Farver TB,  Neutering dogs: effects on joint disorders and cancers in Golden Retrievers. PLoS One. 2013;8(2):e55937. doi:10.1371\/journal.pone.0055937"},{"issue":"3","key":"ref13","series-title":"J Am Vet Med Assoc","first-page":"309","article-title":"Evaluation of the risk and age of onset of cancer and behavioral disorders in gonadectomized Vizslas","volume":"244","author":"Zink MC","year":"2014","unstructured":"Zink MC, Farhoody P, Elser SE, Ruffini LD, Gibbons TA, Rieger RH. Evaluation of the risk and age of onset of cancer and behavioral disorders in gonadectomized Vizslas. J Am Vet Med Assoc. 2014;244(3):309\u2013319. doi:10.2460\/javma.244.3.309"},{"issue":"2","key":"ref14","series-title":"J Vet Intern Med","first-page":"136","article-title":"Canine transitional cell carcinoma","volume":"17","author":"Mutsaers AJ","year":"2003","unstructured":"Mutsaers AJ, Widmer WR, Knapp DW. Canine transitional cell carcinoma. J Vet Intern Med. 2003;17(2):136\u2013144. doi:10.1892\/0891-6640(2003)017<0136:ctcc>2.3.co;2"},{"issue":"3","key":"ref15","series-title":"J Am Vet Med Assoc","first-page":"380","article-title":"Long-term risks and benefits of early-age gonadectomy in dogs","volume":"224","author":"Spain CV","year":"2004","unstructured":"Spain CV, Scarlett JM, Houpt KA. Long-term risks and benefits of early-age gonadectomy in dogs. J Am Vet Med Assoc. 2004;224(3):380\u2013387. doi:10.2460\/javma.2004.224.380"},{"issue":"2","key":"ref16","series-title":"J Am Vet Med Assoc","first-page":"236","article-title":"Effect of age at gonadectomy on the probability of dogs becoming overweight","volume":"243","author":"Lefebvre SL","year":"2013","unstructured":"Lefebvre SL, Yang M, Wang M, Elliott DA, Buff PR, Lund EM. Effect of age at gonadectomy on the probability of dogs becoming overweight. J Am Vet Med Assoc. 2013;243(2):236\u2013243. doi:10.2460\/javma.243.2.236"},{"issue":"7","key":"ref17","series-title":"PLoS One","first-page":"e0209131","article-title":"Age at gonadectomy and risk of overweight\/obesity and orthopedic injury in a cohort of Golden Retrievers","volume":"14","author":"Simpson M","year":"2019","unstructured":"Simpson M, Albright S, Wolfe B,  Age at gonadectomy and risk of overweight\/obesity and orthopedic injury in a cohort of Golden Retrievers. PLoS One. 2019;14(7):e0209131. doi:10.1371\/journal.pone.0209131"},{"issue":"12","key":"ref18","series-title":"J Small Anim Pract","first-page":"595","article-title":"Behavioural effects of ovariohysterectomy on bitches","volume":"31","author":"O\u2019Farrell V","year":"1990","unstructured":"O\u2019Farrell V, Peachey E. Behavioural effects of ovariohysterectomy on bitches. J Small Anim Pract. 1990;31(12):595\u2013598. doi:10.1111\/j.1748-5827.1990.tb00701.x"},{"issue":"1","key":"ref19","series-title":"Vet J","first-page":"154","article-title":"Effects of ovariohysterectomy on reactivity in German Shepherd Dogs","volume":"172","author":"Kim HH","year":"2006","unstructured":"Kim HH, Yeon SC, Houpt KA, Lee HC, Chang HH, Lee HJ. Effects of ovariohysterectomy on reactivity in German Shepherd Dogs. Vet J. 2006;172(1):154\u2013159. doi:10.1016\/j.tvjl.2005.02.028"},{"issue":"5","key":"ref20","series-title":"Vet Surg","first-page":"707","article-title":"Complications related to entry techniques for laparoscopy in 159 dogs and cats","volume":"48","author":"Anderson SJ","year":"2019","unstructured":"Anderson SJ, Fransson BA. Complications related to entry techniques for laparoscopy in 159 dogs and cats. Vet Surg. 2019;48(5):707\u2013714. doi:10.1111\/vsu.13230"},{"key":"ref21","series-title":"Anim Reprod Sci","first-page":"106527","article-title":"Evaluation of completeness of resection of the glandular portion of the uterus with hysterectomy in dogs - a pilot study","volume":"219","author":"Mejia S","year":"2020","unstructured":"Mejia S, Duncan C, Iodence A, Monnet E, Wheeler R, Duerr F. Evaluation of completeness of resection of the glandular portion of the uterus with hysterectomy in dogs - a pilot study. Anim Reprod Sci. 2020;219:106527. doi:10.1016\/j.anireprosci.2020.106527"},{"issue":"2","key":"ref22","series-title":"Vet Surg","first-page":"136","article-title":"Making a rational choice between ovariectomy and ovariohysterectomy in the dog: a discussion of the benefits of either technique","volume":"35","author":"van Goethem B","year":"2006","unstructured":"van Goethem B, Schaefers-Okkens A, Kirpensteijn J. Making a rational choice between ovariectomy and ovariohysterectomy in the dog: a discussion of the benefits of either technique. Vet Surg. 2006;35(2):136\u2013143. doi:10.1111\/j.1532-950X.2006.00124.x"},{"issue":"2","key":"ref23","series-title":"Animals (Basel)","first-page":"553","article-title":"Influence of gonadectomy on canine behavior","volume":"11","author":"Palestrini C","year":"2021","unstructured":"Palestrini C, Mazzola SM, Caione B,  Influence of gonadectomy on canine behavior. Animals (Basel). 2021;11(2):553. doi:10.3390\/ani11020553"},{"issue":"4","key":"ref24","series-title":"J Small Anim Pract","first-page":"198","article-title":"The effect of neutering on the risk of urinary incontinence in bitches - a systematic review","volume":"53","author":"Beauvais W","year":"2012","unstructured":"Beauvais W, Cardwell JM, Brodbelt DC. The effect of neutering on the risk of urinary incontinence in bitches - a systematic review. J Small Anim Pract. 2012;53(4):198\u2013204. doi:10.1111\/j.1748-5827.2011.01176.x"},{"key":"ref25","series-title":"Front Vet Sci","first-page":"342","article-title":"Gonad-sparing surgical sterilization in dogs","volume":"7","author":"Kutzler MA","year":"2020","unstructured":"Kutzler MA. Gonad-sparing surgical sterilization in dogs. Front Vet Sci. 2020;7:342. doi:10.3389\/fvets.2020.00342"},{"issue":"4","key":"ref26","series-title":"Animals (Basel)","first-page":"599","article-title":"Possible relationship between long-term adverse health effects of gonad-removing surgical sterilization and luteinizing hormone in dogs","volume":"10","author":"Kutzler MA","year":"2020","unstructured":"Kutzler MA. Possible relationship between long-term adverse health effects of gonad-removing surgical sterilization and luteinizing hormone in dogs. Animals (Basel). 2020;10(4):599. doi:10.3390\/ani10040599"},{"issue":"7","key":"ref27","series-title":"J Small Anim Pract","first-page":"395","article-title":"Spaying and urinary incontinence in bitches under UK primary veterinary care: a case-control study","volume":"60","author":"Pegram C","year":"2019","unstructured":"Pegram C, O\u2019Neill DG, Church DB, Hall J, Owen L, Brodbelt DC. Spaying and urinary incontinence in bitches under UK primary veterinary care: a case-control study. J Small Anim Pract. 2019;60(7):395\u2013403. doi:10.1111\/jsap.13014"},{"issue":"10","key":"ref28","series-title":"J Am Vet Med Assoc","first-page":"1155","article-title":"A literature review on the welfare implications of gonadectomy of dogs","volume":"250","author":"Houlihan KE","year":"2017","unstructured":"Houlihan KE. A literature review on the welfare implications of gonadectomy of dogs. J Am Vet Med Assoc. 2017;250(10):1155\u20131166. doi:10.2460\/javma.250.10.1155"},{"issue":"suppl 2","key":"ref29","series-title":"Reprod Domest Anim","first-page":"29","article-title":"Gonadectomy in cats and dogs: a review of risks and benefits","volume":"44","author":"Reichler IM","year":"2009","unstructured":"Reichler IM. Gonadectomy in cats and dogs: a review of risks and benefits. Reprod Domest Anim. 2009;44(suppl 2):29\u201335. doi:10.1111\/j.1439-0531.2009.01437.x"},{"issue":"suppl 6","key":"ref30","series-title":"Reprod Domest Anim","first-page":"347","article-title":"Breed variations in the incidence of pyometra and mammary tumours in Swedish dogs","volume":"47","author":"Jitpean S","year":"2012","unstructured":"Jitpean S, Hagman R, Str\u00f6m Holst B, H\u00f6glund OV, Pettersson A, Egenvall A. Breed variations in the incidence of pyometra and mammary tumours in Swedish dogs. Reprod Domest Anim. 2012;47(suppl 6):347\u2013350. doi:10.1111\/rda.12103"},{"issue":"11","key":"ref31","series-title":"J Am Vet Med Assoc","first-page":"1409","article-title":"Ovariohysterectomy versus ovariectomy for elective sterilization of female dogs and cats: is removal of the uterus necessary?","volume":"239","author":"DeTora M","year":"2011","unstructured":"DeTora M, McCarthy RJ. Ovariohysterectomy versus ovariectomy for elective sterilization of female dogs and cats: is removal of the uterus necessary? J Am Vet Med Assoc. 2011;239(11):1409\u20131412. doi:10.2460\/javma.239.11.1409"},{"issue":"5","key":"ref32","series-title":"J Small Anim Pract","first-page":"257","article-title":"The complications of ovariohysterectomy in the bitch","volume":"14","author":"Pearson H","year":"1973","unstructured":"Pearson H. The complications of ovariohysterectomy in the bitch. J Small Anim Pract. 1973;14(5):257\u2013266. doi:10.1111\/j.1748-5827.1973.tb06457.x"},{"issue":"22","key":"ref33","series-title":"Tijdschr Diergeneeskd","first-page":"1142","article-title":"Gynaecologische complicaties na ovariohysterectomie bij de hond ten gevolge van: 1. Het incompleet verwijderen van de ovaria. 2. Een ontsteking van de uterus-cervixsomp","volume":"106","author":"Okkens AC","year":"1981","unstructured":"Okkens AC, Dieleman SJ, v d Gaag I. Gynaecologische complicaties na ovariohysterectomie bij de hond ten gevolge van: 1. Het incompleet verwijderen van de ovaria. 2. Een ontsteking van de uterus-cervixsomp. Tijdschr Diergeneeskd. 1981;106(22):1142\u20131158."},{"issue":"5","key":"ref34","series-title":"J Am Vet Med Assoc","first-page":"548","article-title":"Ovarian remnant syndrome in dogs and cats: 21 cases (2000-2007)","volume":"236","author":"Ball RL","year":"2010","unstructured":"Ball RL, Birchard SJ, May LR, Threlfall WR, Young GS. Ovarian remnant syndrome in dogs and cats: 21 cases (2000-2007). J Am Vet Med Assoc. 2010;236(5):548\u2013553. doi:10.2460\/javma.236.5.548"},{"issue":"1","key":"ref35","series-title":"BMC Vet Res","first-page":"333","article-title":"A laparoscopic approach for removal of ovarian remnant tissue in 32 dogs","volume":"14","author":"van Nimwegen SA","year":"2018","unstructured":"van Nimwegen SA, Van Goethem B, de Gier J, Kirpensteijn J. A laparoscopic approach for removal of ovarian remnant tissue in 32 dogs. BMC Vet Res. 2018;14(1):333 doi:10.1186\/s12917-018-1658-y"},{"issue":"4","key":"ref36","series-title":"J Am Vet Med Assoc","first-page":"443","article-title":"Outcome of laparoscopic ovariectomy and laparoscopic-assisted ovariohysterectomy in dogs: 278 cases (2003-2013)","volume":"251","author":"Corriveau KM","year":"2017","unstructured":"Corriveau KM, Giuffrida MA, Mayhew PD, Runge JJ. Outcome of laparoscopic ovariectomy and laparoscopic-assisted ovariohysterectomy in dogs: 278 cases (2003-2013). J Am Vet Med Assoc. 2017;251(4):443\u2013450. doi:10.2460\/javma.251.4.443"},{"issue":"1","key":"ref37","series-title":"J Vet Intern Med","first-page":"230","article-title":"Effect of ovariohysterectomy at the time of tumor removal in dogs with mammary carcinomas: a randomized controlled trial","volume":"30","author":"Kristiansen VM","year":"2016","unstructured":"Kristiansen VM, Pe\u00f1a L, D\u00edez C\u00f3rdova L,  Effect of ovariohysterectomy at the time of tumor removal in dogs with mammary carcinomas: a randomized controlled trial. J Vet Intern Med. 2016;30(1):230\u2013241. doi:10.1111\/jvim.13812"},{"issue":"4","key":"ref38","series-title":"J Vet Intern Med","first-page":"935","article-title":"Effect of ovariohysterectomy at the time of tumor removal in dogs with benign mammary tumors and hyperplastic lesions: a randomized controlled clinical trial","volume":"27","author":"Kristiansen VM","year":"2013","unstructured":"Kristiansen VM, N\u00f8dtvedt A, Breen AM,  Effect of ovariohysterectomy at the time of tumor removal in dogs with benign mammary tumors and hyperplastic lesions: a randomized controlled clinical trial. J Vet Intern Med. 2013;27(4):935\u2013942. doi:10.1111\/jvim.12110"},{"issue":"2","key":"ref39","series-title":"J Vet Intern Med","first-page":"419","article-title":"Relationship among insulin resistance, growth hormone, and insulin-like growth factor I concentrations in diestrous Swedish Elkhounds","volume":"28","author":"Strage EM","year":"2014","unstructured":"Strage EM, Lewitt MS, Hanson JM,  Relationship among insulin resistance, growth hormone, and insulin-like growth factor I concentrations in diestrous Swedish Elkhounds. J Vet Intern Med. 2014;28(2):419\u2013428. doi:10.1111\/jvim.12307"},{"issue":"3","key":"ref40","series-title":"Res Vet Sci","first-page":"471","article-title":"Diabetes mellitus remission after resolution of inflammatory and progesterone-related conditions in bitches","volume":"94","author":"P\u00f6ppl AG","year":"2013","unstructured":"P\u00f6ppl AG, Mottin TS, Gonz\u00e1lez FHD. Diabetes mellitus remission after resolution of inflammatory and progesterone-related conditions in bitches. Res Vet Sci. 2013;94(3):471\u2013473. doi:10.1016\/j.rvsc.2012.10.008"},{"key":"ref41","series-title":"Res Vet Sci","first-page":"469","article-title":"Canine diabetes mellitus risk factors: a matched case-control study","volume":"114","author":"P\u00f6ppl AG","year":"2017","unstructured":"P\u00f6ppl AG, de Carvalho GLC, Vivian IF, Corbellini LG, Gonz\u00e1lez FHD. Canine diabetes mellitus risk factors: a matched case-control study. Res Vet Sci. 2017;114:469\u2013473. doi:10.1016\/j.rvsc.2017.08.003"},{"issue":"2","key":"ref42","series-title":"Acta Endocrinol (Copenh)","first-page":"167","article-title":"Progesterone-controlled growth hormone overproduction and naturally occurring canine diabetes and acromegaly","volume":"104","author":"Eigenmann JE","year":"1983","unstructured":"Eigenmann JE, Eigenmann RY, Rijnberk A, van der Gaag I, Zapf J, Froesch ER. Progesterone-controlled growth hormone overproduction and naturally occurring canine diabetes and acromegaly. Acta Endocrinol (Copenh). 1983;104(2):167\u2013176. doi:10.1530\/acta.0.1040167"},{"issue":"4","key":"ref43","series-title":"Eur J Endocrinol","first-page":"413","article-title":"Progestin treatment in the dog. I. Effects on growth hormone, insulin-like growth factor I and glucose homeostasis","volume":"131","author":"Selman PJ","year":"1994","unstructured":"Selman PJ, Mol JA, Rutteman GR, Rijnberk A. Progestin treatment in the dog. I. Effects on growth hormone, insulin-like growth factor I and glucose homeostasis. Eur J Endocrinol. 1994;131(4):413\u2013421. doi:10.1530\/eje.0.1310413"},{"issue":"3","key":"ref44","series-title":"Vet J","first-page":"240","article-title":"Time trends and risk factors for diabetes mellitus in dogs: analysis of veterinary medical data base records (1970-1999)","volume":"165","author":"Guptill L","year":"2003","unstructured":"Guptill L, Glickman L, Glickman N. Time trends and risk factors for diabetes mellitus in dogs: analysis of veterinary medical data base records (1970-1999). Vet J. 2003;165(3):240\u2013247. doi:10.1016\/s1090-0233(02)00242-3"},{"issue":"7 suppl","key":"ref45","series-title":"J Nutr","first-page":"1985S","article-title":"Feeding, exercise, and weight identified as risk factors in canine diabetes mellitus","volume":"136","author":"Klinkenberg H","year":"2006","unstructured":"Klinkenberg H, Sallander MH, Hedhammar A. Feeding, exercise, and weight identified as risk factors in canine diabetes mellitus. J Nutr. 2006;136(7 suppl):1985S\u20131987S. doi:10.1093\/jn\/136.7.1985S"},{"issue":"1","key":"ref46","series-title":"Canine Genet Epidemiol","first-page":"6","article-title":"Correlation of neuter status and expression of heritable disorders","volume":"4","author":"Belanger JM","year":"2017","unstructured":"Belanger JM, Bellumori TP, Bannasch DL, Famula TR, Oberbauer AM. Correlation of neuter status and expression of heritable disorders. Canine Genet Epidemiol. 2017;4(1):6. doi:10.1186\/s40575-017-0044-6"},{"issue":"62","key":"ref47","series-title":"Clin Orthop Relat Res","first-page":"54","article-title":"Canine osteosarcoma. A clinicopathologic study of 194 cases","volume":"62","author":"Brodey RS","year":"1969","unstructured":"Brodey RS, Riser WH. Canine osteosarcoma. A clinicopathologic study of 194 cases. Clin Orthop Relat Res. 1969;62(62):54\u201364."},{"key":"ref48","series-title":"J Cancer Epidemiol","first-page":"591753","article-title":"Hormonal and sex impact on the epidemiology of canine lymphoma","volume":"2009","author":"Villamil JA","year":"2009","unstructured":"Villamil JA, Henry CJ, Hahn AW, Bryan JN, Tyler JW, Caldwell CW. Hormonal and sex impact on the epidemiology of canine lymphoma. J Cancer Epidemiol. 2009;2009:591753. doi:10.1155\/2009\/591753"},{"key":"ref49","series-title":"Front Vet Sci","first-page":"18","article-title":"Aggression toward familiar people, strangers, and conspecifics in gonadectomized and intact dogs","volume":"5","author":"Farhoody P","year":"2018","unstructured":"Farhoody P, Mallawaarachchi I, Tarwater PM, Serpell JA, Duffy DL, Zink C. Aggression toward familiar people, strangers, and conspecifics in gonadectomized and intact dogs. Front Vet Sci. 2018;5:18. doi:10.3389\/fvets.2018.00018"},{"issue":"12","key":"ref50","series-title":"PLoS One","first-page":"e0223709","article-title":"Behavioural risks in female dogs with minimal lifetime exposure to gonadal hormones","volume":"14","author":"Starling M","year":"2019","unstructured":"Starling M, Fawcett A, Wilson B, Serpell J, McGreevy P. Behavioural risks in female dogs with minimal lifetime exposure to gonadal hormones. 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