{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:36:39Z","timestamp":1791286599931,"version":"4.1.0"},"reference-count":48,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2006,6,1]]},"abstract":"Abstract<\/jats:title>\nObjective<\/jats:bold>\u2014To evaluate microbiologic findings in dogs with infective endocarditis (IE) and determine whether there were differences in clinical features of disease caused by different groups of infective agents.<\/jats:p>\nDesign<\/jats:bold>\u2014Retrospective case series.<\/jats:p>\nAnimals<\/jats:bold>\u201471 dogs with suspected or definite IE.<\/jats:p>\nProcedures<\/jats:bold>\u2014Medical records were reviewed for results of bacterial culture and susceptibility testing, serologic assays for vector-borne disease, and PCR testing on vegetative growths. Cases were grouped by causative organism and relationships among infectious agent group, and various hematologic, biochemical, and clinical variables were determined. Survival analyses were used to determine associations between infecting organisms and outcome.<\/jats:p>\nResults<\/jats:bold>\u2014Causative bacteria were identified in 41 of 71 (58%) dogs. Gram-positive cocci were the causative agents in most (21\/41; 51%) infections, with Streptococcus canis<\/jats:italic> associated with 24% of infections. Gramnegative organisms were detected in 9 of the 41 (22%) dogs. Infection with Bartonella<\/jats:italic> spp was detected in 6 of 31 (19%) dogs with negative results for microbial growth on blood culture. Aortic valve involvement and congestive heart failure were more frequent in dogs with endocarditis from Bartonella<\/jats:italic> spp infection, and those dogs were more likely to be afebrile. Infection with Bartonella<\/jats:italic> spp was negatively correlated with survival. Mitral valve involvement and polyarthritis were more frequent in dogs with streptococcal endocarditis.<\/jats:p>\nConclusions and Clinical Relevance<\/jats:bold>\u2014Streptococci were the most common cause of IE and were more likely to infect the mitral valve and be associated with polyarthritis. Dogs with IE secondary to Bartonella<\/jats:italic> spp infection were often afebrile, more likely to develop congestive heart failure, rarely had mitral valve involvement, and had shorter survival times.<\/jats:p>","DOI":"10.2460\/javma.228.11.1723","type":"journal-article","created":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T19:53:23Z","timestamp":1149191603000},"page":"1723-1734","source":"Crossref","is-referenced-by-count":89,"title":["Evaluation of the relationship between causative organisms and clinical characteristics of infective endocarditis in dogs: 71 cases (1992\u20132005)"],"prefix":"10.2460","volume":"228","author":[{"given":"Jane E.","family":"Sykes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Kittleson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Pesavento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Byrne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin A.","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno B.","family":"Chomel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Vet Intern Med","first-page":"899","article-title":"Mitral valve endocarditis in a Labrador Retriever caused by an actinomyces species identified as Actinomyces turicensis","volume":"18","author":"Junius","year":"2004"},{"key":"ref2","series-title":"J Am Vet Med Assoc","first-page":"278","article-title":"Acute vegetative endocarditis in the dog and 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