{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:51:01Z","timestamp":1781650261039,"version":"3.54.5"},"reference-count":53,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2006,6,15]]},"abstract":"Abstract<\/jats:title>\nObjective<\/jats:bold>\u2014To evaluate antimicrobial susceptibility of commensal Escherichia coli<\/jats:italic> strains isolated from the feces of horses and investigate relationships with hospitalization and antimicrobial drug (AMD) administration.<\/jats:p>\nDesign<\/jats:bold>\u2014Observational study.<\/jats:p>\nAnimals<\/jats:bold>\u201468 hospitalized horses that had been treated with AMDs for at least 3 days (HOSP\u2013AMD group), 63 hospitalized horses that had not received AMDs for at least 4 days (HOSP\u2013NOAMD group), and 85 healthy horses that had not been hospitalized or treated with AMDs (community group).<\/jats:p>\nProcedures<\/jats:bold>\u2014Fecal samples were submitted for bacterial culture, and up to 3 E coli<\/jats:italic> colonies were recovered from each sample. Antimicrobial susceptibility of 724 isolates was evaluated. Prevalence of resistance was compared among groups by use of log-linear modeling.<\/jats:p>\nResults<\/jats:bold>\u2014For 12 of the 15 AMDs evaluated, prevalence of antimicrobial resistance differed significantly among groups, with prevalence being highest among isolates from the HOSP\u2013AMD group and lowest among isolates from the community group. Isolates recovered from the HOSP\u2013AMD and HOSP\u2013NOAMD groups were also significantly more likely to be resistant to multiple AMDs. Resistance to sulfamethoxazole and resistance to trimethoprim-sulfamethoxazole were most common, followed by resistance to gentamicin and resistance to tetracycline. Use of a potentiated sulfonamide, aminoglycosides, cephalosporins, or metronidazole was positively associated with resistance to 1 or more AMDs, but use of penicillins was not associated with increased risk of resistance to AMDs.<\/jats:p>\nConclusion and Clinical Relevance<\/jats:bold>\u2014Results suggest that both hospitalization and AMD administration were associated with prevalence of antimicrobial resistance among E coli<\/jats:italic> strains isolated from the feces of horses.<\/jats:p>","DOI":"10.2460\/javma.228.12.1909","type":"journal-article","created":{"date-parts":[[2006,6,19]],"date-time":"2006-06-19T13:30:16Z","timestamp":1150723816000},"page":"1909-1917","source":"Crossref","is-referenced-by-count":64,"title":["Impact of hospitalization and antimicrobial drug administration on antimicrobial susceptibility patterns of commensal Escherichia coli isolated from the feces of horses"],"prefix":"10.2460","volume":"228","author":[{"given":"Magdalena","family":"Dunowska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Morley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josie L.","family":"Traub-Dargatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doreene R.","family":"Hyatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Dargatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Veterinary microbiology","first-page":"61","article-title":"Enterobacteriaceae: Escherichia","author":"Hirsch","year":"2004"},{"key":"ref2","series-title":"Science","first-page":"1999","article-title":"Microbiology. 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