{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:54:29Z","timestamp":1787025269443,"version":"build-2736575974"},"reference-count":29,"publisher":"American Veterinary Medical Association (AVMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,1,15]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:bold>\n \u2014To evaluate completeness of excision and clinical outcome in dogs with cutaneous mast cell tumors (MCTs) excised with a lateral margin of 2 cm and a deep margin of 1 fascial plane.\n <\/jats:p>\n \n Design<\/jats:bold>\n \u2014Prospective study.\n <\/jats:p>\n \n Animals<\/jats:bold>\n \u201416 client-owned dogs with 1 or more cutaneous MCTs.\n <\/jats:p>\n \n Procedure<\/jats:bold>\n \u2014Excision of MCTs was performed with a 2-cm lateral margin and a deep margin of 1 fascial plane. Histologic tumor grading was performed; surgical margins were categorized as complete or incomplete. Follow-up information was obtained via repeat examination of the dogs by veterinarians or client-completed questionnaires.\n <\/jats:p>\n \n Results<\/jats:bold>\n \u20144 grade I and 19 grade II cutaneous MCTs were evaluated. Overall, 21 (91%) MCTs were completely excised; 2 grade II tumors had foci of mast cells at the 2-cm margin. Two dogs received adjunctive treatments following surgery. Follow-up information was available for all dogs (median follow-up period, 379 days; range, 51 to 538 days); no local recurrence was detected during this time. De novo MCTs were detected in 3 of 16 dogs at 37, 54, and 154 days after surgery. Via Kaplan-Meier analysis, median survival time and disease-free interval were both > 538 days (medians not yet reached). No prognostic variables were identified.\n <\/jats:p>\n \n Conclusions and Clinical Relevance<\/jats:bold>\n \u2014Excision with a 2-cm lateral margin and a deep margin of 1 fascial plane may result in satisfactory excision of grades I and II MCTs in dogs, with recurrence rates similar to those reported previously. Use of these margins may minimize complications associated with larger local tumor resection.\n <\/jats:p>","DOI":"10.2460\/javma.228.2.210","type":"journal-article","created":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T17:24:21Z","timestamp":1137777861000},"page":"210-215","source":"Crossref","is-referenced-by-count":89,"title":["Evaluation of a two-centimeter lateral surgical margin for excision of grade I and grade II cutaneous mast cell tumors in dogs"],"prefix":"10.2460","volume":"228","author":[{"given":"Ryan P.","family":"Fulcher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori L.","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Bergman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley J.","family":"Newman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia M.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amiya K.","family":"Patnaik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Small animal clinical oncology","first-page":"261","article-title":"Mast cell tumors","author":"Thamm","year":"2001"},{"key":"ref2","series-title":"Semin Vet Med Surg (Small Anim)","first-page":"72","article-title":"Canine and feline mast cell tumors: biologic behavior, diagnosis, and therapy","volume":"1","author":"Macy","year":"1986"},{"key":"ref3","series-title":"Vet Clin North Am Small Anim Pract","first-page":"87","article-title":"Mast cell tumors: dilemmas of diagnosis and 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