{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T14:20:27Z","timestamp":1779373227613,"version":"3.53.1"},"reference-count":15,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2006,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To determine results of diagnostic testing, including detection of nasal or frontal sinus fungal plaques, in dogs with nasal aspergillosis.<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Retrospective case series.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u201446 dogs with nasal aspergillosis.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Medical records were reviewed for information on computed tomographic findings; rhinoscopic findings, including whether fungal plaques were seen in the nasal cavity; results of frontal sinus trephination and sinuscopy, including whether fungal plaques were seen in the frontal sinus; and results of histologic examination of biopsy specimens.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014In 38 (83%) dogs, fungal plaques were seen in the nasal cavity during rhinoscopy, whereas in the remaining 8 (17%), fungal plaques were not seen in the nasal cavity but were seen in the frontal sinus. Duration of clinical signs, proportions of dogs in which the referring veterinarian had performed a nasal examination prior to referral, proportions of dogs with computed tomographic evidence of nasal cavity cavitation or sinus involvement, and proportions of dogs with rhinoscopic evidence of destructive rhinitis were not significantly different between dogs with nasal fungal plaques and dogs with fungal plaques only in the frontal sinus.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results confirm that frontal sinus involvement is common in dogs with nasal aspergillosis and suggest that frontal sinus trephination and sinuscopy may aid in the diagnosis of aspergillosis in dogs, particularly dogs with rhinoscopic evidence of destructive rhinitis and computed tomographic evidence of sinus involvement that lack detectable fungal plaques in the nasal cavity.<\/jats:p>","DOI":"10.2460\/javma.228.5.738","type":"journal-article","created":{"date-parts":[[2006,2,28]],"date-time":"2006-02-28T22:22:25Z","timestamp":1141165345000},"page":"738-742","source":"Crossref","is-referenced-by-count":38,"title":["Results of rhinoscopy alone or in conjunction with sinuscopy in dogs with aspergillosis: 46 cases (2001\u20132004)"],"prefix":"10.2460","volume":"228","author":[{"given":"Lynelle R.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy L.","family":"Drazenovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa A.","family":"Herrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik R.","family":"Wisner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Infectious diseases of the dog and cat","first-page":"404","article-title":"Aspergillosis and penicilliosis","author":"Sharp","year":"1998"},{"key":"ref2","series-title":"Blood","first-page":"2258","article-title":"Aspergillus fumigatus suppresses the human cellular immune response via gliotoxin-mediated apoptosis of monocytes","volume":"105","author":"Stanzani","year":"2005"},{"key":"ref3","series-title":"J Med Microbiol","first-page":"175","article-title":"Production of melanin by Aspergillus fumigatus","volume":"53","author":"Youngchim","year":"2004"},{"key":"ref4","series-title":"Mycoses","first-page":"277","article-title":"Paranasal sinus aspergillosis: its categorization to develop a treatment protocol","volume":"47","author":"Panda","year":"2004"},{"key":"ref5","series-title":"J Am Vet Med Assoc","first-page":"48","article-title":"Nasal aspergillosis and penicilliosis in dogs: results of treatment with thiabendazole","volume":"184","author":"Harvey","year":"1984"},{"key":"ref6","series-title":"J Small Anim Pract","first-page":"513","article-title":"Treatment of canine nasal aspergillosis\/penicilliosis with fluconazole (UK-49,858)","volume":"32","author":"Sharp","year":"1991"},{"key":"ref7","series-title":"Vet Surg","first-page":"309","article-title":"Computed tomographic assessment of noninvasive intranasal infusions in dogs with fungal rhinitis","volume":"25","author":"Mathews","year":"1996"},{"key":"ref8","series-title":"J Am Vet Med Assoc","first-page":"501","article-title":"Comparison of topical administration of clotrimazole through surgically placed versus nonsurgically placed catheters for treatment of nasal aspergillosis in dogs: 60 cases (1990\u20131996)","volume":"213","author":"Mathews","year":"1998"},{"key":"ref9","series-title":"J Am Vet Med Assoc","first-page":"1421","article-title":"Intranasal infusion of enilconazole for treatment of sinonasal aspergillosis in dogs","volume":"221","author":"Zonderland","year":"2002"},{"key":"ref10","series-title":"J Am Vet Med Assoc","first-page":"1703","article-title":"Radiographic, magnetic resonance imaging, computed tomographic, and rhinoscopic features of nasal aspergillosis in dogs","volume":"225","author":"Saunders","year":"2004"},{"key":"ref11","series-title":"J Comp Pathol","first-page":"283","article-title":"An immunohistochemical study of canine nasal aspergillosis","volume":"132","author":"Peeters","year":"2005"},{"key":"ref12","series-title":"Vet Radiol Ultrasound","first-page":"414","article-title":"Comparison of radiography and computed tomography for the diagnosis of canine nasal aspergillosis","volume":"44","author":"Saunders","year":"2003"},{"key":"ref13","series-title":"Vet Radiol Ultrasound","first-page":"5","article-title":"Computed tomographic findings in 35 dogs with nasal aspergillosis","volume":"43","author":"Saunders","year":"2002"},{"key":"ref14","series-title":"Current veterinary therapy VIII","first-page":"236","article-title":"Nasal aspergillosis-penicilliosis","author":"Harvey","year":"1983"},{"key":"ref15","series-title":"Vet Surg","first-page":"476","article-title":"Distribution of topical agents in the frontal sinuses and nasal cavity of dogs: comparison between current protocols for treatment of nasal aspergillosis and a new noninvasive technique","volume":"24","author":"Richardson","year":"1995"}],"container-title":["Journal of the American Veterinary Medical 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