{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T18:17:23Z","timestamp":1774030643910,"version":"3.50.1"},"reference-count":23,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2006,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Case Description<\/jats:bold>\u2014A 2-year-old Siberian Husky was evaluated because of a 2-week history of coughing and gagging and decreased appetite and activity level.<\/jats:p>\n<jats:p><jats:bold>Clinical Findings<\/jats:bold>\u2014Radiography, surgery, and immunohistochemical examination revealed a solitary sclerosing mesothelioma extending from the left thoracic diaphragmatic surface that was adherent to the pericardium and the caudal mediastinum.<\/jats:p>\n<jats:p><jats:bold>Treatment and Outcome<\/jats:bold>\u2014The tumor was resected along with most of the left hemidiaphragm, and the left transversus abdominis muscle was used to reconstruct the diaphragm. The 13th rib formed the base of the muscle flap. The muscle flap was transposed into the defect so that the mesothelium-lined surface faced the thoracic cavity and the deep aspect of the muscle formed the abdominal surface of the diaphragm. To minimize risk of adhesions, the exposed raw aspect of the abdominal surface was covered with porcine small intestinal submucosa. Recovery was uncomplicated, and the dog's appetite and activity level soon returned to normal. Evaluation 54 days after surgery revealed 2 subcutaneous masses on the thorax and masses in the liver and both kidneys; histologic and immunohistochemical analyses revealed metastasis of the original tumor. The dog was euthanatized.<\/jats:p>\n<jats:p><jats:bold>Clinical Relevance<\/jats:bold>\u2014Hemidiaphragmatic reconstruction with a transversus abdominis muscle flap after resection of a diaphragmatic tumor was successful. The muscle flap was easily harvested and transposed into the diaphragmatic defect.<\/jats:p>","DOI":"10.2460\/javma.228.8.1204","type":"journal-article","created":{"date-parts":[[2006,4,17]],"date-time":"2006-04-17T14:05:12Z","timestamp":1145282712000},"page":"1204-1208","source":"Crossref","is-referenced-by-count":19,"title":["Hemidiaphragmatic reconstruction with a transversus abdominis muscle flap after resection of a solitary diaphragmatic mesothelioma in a dog"],"prefix":"10.2460","volume":"228","author":[{"given":"Julius M.","family":"Liptak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas S.","family":"Brebner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Small animal clinical oncology","first-page":"656","article-title":"Mesothelioma.","author":"Garrett","year":"2001"},{"key":"ref2","series-title":"Clinical oncology","first-page":"1745","article-title":"Tumors of the pleura and mediastinum.","author":"Aisner","year":"2004"},{"key":"ref3","series-title":"J Am Anim Hosp Assoc","first-page":"319","article-title":"Peripheral nerve sheath tumor of the diaphragm with osseous differentiation in a oneyear-old dog","volume":"35","author":"Anderson","year":"1999"},{"key":"ref4","series-title":"Chest Surg Clin N Am","first-page":"441","article-title":"Tumors of the diaphragm","volume":"8","author":"Weksler","year":"1998"},{"key":"ref5","series-title":"Chest","first-page":"1318","article-title":"Malignant pleural mesothelioma: update, current management, and newer therapeutic strategies","volume":"126","author":"Pistolesi","year":"2004"},{"key":"ref6","series-title":"Cancer","first-page":"1994","article-title":"The production of malignant tumors of the lung and pleura in dogs from intratracheal asbestos instillation and cigarette smoking","volume":"47","author":"Humphrey","year":"1981"},{"key":"ref7","series-title":"Environ Res","first-page":"305","article-title":"Mesothelioma in pet dogs associated with exposure of their owners to asbestos","volume":"32","author":"Glickman","year":"1983"},{"key":"ref8","series-title":"Vet Pathol","first-page":"531","article-title":"Malignant mesothelioma in urban dogs","volume":"20","author":"Harbison","year":"1983"},{"key":"ref9","series-title":"Pathol Int","first-page":"654","article-title":"Localized malignant mesothelioma of the pleura","volume":"51","author":"Okamura","year":"2001"},{"key":"ref10","series-title":"Pathol Int","first-page":"616","article-title":"Localized pleural malignant mesothelioma","volume":"53","author":"Hirano","year":"2003"},{"key":"ref11","series-title":"J Am Anim Hosp Assoc","first-page":"745","article-title":"Sclerosing mesothelioma in five dogs","volume":"15","author":"Dubielzig","year":"1979"},{"key":"ref12","series-title":"J Vet Diagn Invest","first-page":"217","article-title":"Sclerosing peritoneal mesothelioma in a dog evaluated by electron microscopy and immunoperoxidase techniques","volume":"4","author":"Schoning","year":"1992"},{"key":"ref13","series-title":"J Am Vet Med Assoc","first-page":"791","article-title":"Abdominal flap graft for repair of chronic diaphragmatic hernia in the dog","volume":"181","author":"Helphrey","year":"1982"},{"key":"ref14","series-title":"Textbook of small animal surgery","first-page":"471","article-title":"Diaphragmatic, pericardial, and hiatal hernia.","author":"Hunt","year":"2003"},{"key":"ref15","series-title":"J Pediatr Surg","first-page":"362","article-title":"Prosthetic materials and muscle flaps in the repair of extensive diaphragmatic defects: an experimental study","volume":"20","author":"Newman","year":"1985"},{"key":"ref16","series-title":"Ann Thorac Surg","first-page":"209","article-title":"Reconstruction of diaphragm using autologous fascia lata: an experimental study in dogs","volume":"74","author":"Suzuki","year":"2002"},{"key":"ref17","series-title":"J Thorac Cardiovasc Surg","first-page":"846","article-title":"Reverse flap of distal latissimus dorsi for diaphragm reconstruction in the adult: specification of the technical procedure and report on six cases","volume":"114","author":"Bedini","year":"1997"},{"key":"ref18","series-title":"Eur J Pediatr Surg","first-page":"8","article-title":"Surgical treatment of diaphragmatic agenesis by transposition of a muscle flap: report on 15 cases","volume":"10","author":"Pelizzo","year":"2000"},{"key":"ref19","series-title":"J Pediatr Surg","first-page":"1637","article-title":"Reconstruction of congenital agenesis of hemidiaphragm by combined reverse latissimus dorsi and serratus anterior muscle flaps","volume":"36","author":"Samarakkody","year":"2001"},{"key":"ref20","series-title":"Compend Contin Educ Pract Vet","first-page":"395","article-title":"Use of muscle flaps in reconstructive surgery","volume":"18","author":"Philibert","year":"1996"},{"key":"ref21","series-title":"J Pediatr Surg","first-page":"167","article-title":"Evaluation of small intestine submucosa and acellular dermis as diaphragmatic prostheses","volume":"34","author":"Vecchia","year":"1999"},{"key":"ref22","series-title":"J Am Vet Med Assoc","first-page":"1580","article-title":"Phase II evaluation of doxorubicin for treatment of various canine neoplasms","volume":"195","author":"Ogilvie","year":"1989"},{"key":"ref23","series-title":"J Am Vet Med Assoc","first-page":"1618","article-title":"Efficacy of mitoxantrone against various neoplasms in dogs","volume":"198","author":"Ogilvie","year":"1991"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/228\/8\/javma.228.8.1204.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/228\/8\/javma.228.8.1204.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/228\/8\/javma.228.8.1204.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T13:36:09Z","timestamp":1741354569000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/228\/8\/javma.228.8.1204.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,15]]},"references-count":23,"journal-issue":{"issue":"8"},"URL":"https:\/\/doi.org\/10.2460\/javma.228.8.1204","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2006,4,15]]}}}