{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:54:13Z","timestamp":1787025253159,"version":"build-2736575974"},"reference-count":41,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2006,8,15]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:bold>\n \u2014To determine outcome for dogs with nonresectable thyroid carcinomas treated with sodium iodide I 131 and identify factors associated with outcome.\n <\/jats:p>\n \n Design<\/jats:bold>\n \u2014Retrospective case series.\n <\/jats:p>\n \n Animals<\/jats:bold>\n \u201439 dogs.\n <\/jats:p>\n \n Procedures<\/jats:bold>\n \u2014A definitive or presumptive diagnosis of thyroid tumor was made on the basis of cytologic or histologic examination, abnormal accumulation of sodium pertechnetate Tc 99m during scintigraphy, or both, and dogs were treated with sodium iodide I 131. Dogs with cervical thyroid tumors were evaluated 3 to 6 weeks after\n 131<\/jats:sup>\n I therapy, and residual tumor was resected when feasible.\n <\/jats:p>\n \n Results<\/jats:bold>\n \u2014Prior to\n 131<\/jats:sup>\n I therapy, 32 dogs had a solitary mass and 7 had metastases; 21 were hyperthyroid, 16 were euthyroid, and 2 were hypothyroid. Median survival time for dogs with local or regional tumors (ie, stage II or III) was significantly longer (839 days) than median survival time for dogs with metastasis (366 days). Tumor site (cervical vs ectopic), dose of sodium iodide I 131, age, body weight, treatment (\n 131<\/jats:sup>\n I therapy alone vs\n 131<\/jats:sup>\n I therapy followed by surgery), and serum T\n 4<\/jats:sub>\n concentration prior to\n 131<\/jats:sup>\n I therapy were not significantly associated with survival time. Three dogs died of radioiodine-associated myelosuppression within 3 months after treatment, but no specific factor associated with development of toxicosis was identified.\n <\/jats:p>\n \n Conclusions and Clinical Relevance<\/jats:bold>\n \u2014Results suggested that\n 131<\/jats:sup>\n I therapy may result in prolonged survival times in dogs with nonresectable thyroid tumors, regardless of serum thyroxine concentration prior to treatment. Dogs undergoing\n 131<\/jats:sup>\n I therapy should be monitored for signs of bone marrow suppression.\n <\/jats:p>","DOI":"10.2460\/javma.229.4.542","type":"journal-article","created":{"date-parts":[[2006,8,15]],"date-time":"2006-08-15T10:03:54Z","timestamp":1155636234000},"page":"542-548","source":"Crossref","is-referenced-by-count":62,"title":["Sodium iodide I 131 treatment of dogs with nonresectable thyroid tumors: 39 cases (1990\u20132003)"],"prefix":"10.2460","volume":"229","author":[{"given":"Jane M.","family":"Turrel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret C.","family":"McEntee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blaise P.","family":"Burke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney 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