{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T06:53:39Z","timestamp":1760079219964,"version":"3.38.0"},"reference-count":9,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2006,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To evaluate the clinical efficacy of a single injection of tulathromycin, compared with saline (0.9% NaCl) solution-treated control calves, for treatment of induced infectious bovine keratoconjunctivitis in calves.<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Clinical trial.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u201430 Holstein bull calves ranging from 5 to 6 months old and 75 to 200 kg (165 to 440 lb) with no history of <jats:italic>Moraxella bovis<\/jats:italic> infections, no history of <jats:italic>M bovis<\/jats:italic> vaccination, and negative results for <jats:italic>M bovis<\/jats:italic> on 3 consecutive ocular bacterial cultures.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Both eyes of each calf were infected with 1 X 10<jats:sup>10<\/jats:sup> colony-forming units of piliated <jats:italic>M bovis<\/jats:italic> for 3 consecutive days prior to the trial. On day 0, ocular lesion scores were determined for each calf and the calves were weighed and assigned to a treatment (2.5 mg\/kg [1.14 mg\/lb] of body weight, SC) or control group according to a stratified random allocation based on weight and lesion score. Eyes were stained with fluorescein and photographed daily to record healing. Eyes were evaluated bacteriologically for <jats:italic>M bovis<\/jats:italic> on days 0 to 6 and at 3-day intervals thereafter.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014Median time to ulcer resolution in calves treated with tulathromycin was 9.1 days. More than 50% of control calves still had ulcers at the end of the trial (21 days). <jats:italic>Moraxella<\/jats:italic> sp was isolated less often from the eyes of treated calves than from the control calves. By day 10, the treated calves had lower ocular lesion scores than control calves.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014A single dose of tulathromycin (SC) was an effective treatment of calves with experimentally induced infectious bovine keratoconjunctivitis. The long serum half-life of tulathromycin, along with the results of this trial, suggests that tulathromycin may be a rational choice as a single-injection treatment for infectious bovine keratoconjunctivitis.<\/jats:p>","DOI":"10.2460\/javma.229.4.557","type":"journal-article","created":{"date-parts":[[2006,8,15]],"date-time":"2006-08-15T14:03:54Z","timestamp":1155650634000},"page":"557-561","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy of tulathromycin for treatment of cattle with acute ocular Moraxella bovis infections"],"prefix":"10.2460","volume":"229","author":[{"given":"V. Michael","family":"Lane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisle W.","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn M.","family":"Cleaver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Vet Bull","first-page":"349","article-title":"Infectious bovine keratoconjunctivitis: a review","volume":"38","author":"Wilcox","year":"1968"},{"key":"ref2","article-title":"USDA Animal and Plant Health Inspection Service Web site"},{"key":"ref3","series-title":"J Am Vet Med Assoc","first-page":"823","article-title":"Risk factors related to the prevalence of infectious bovine keratoconjunctivitis","volume":"179","author":"Webber","year":"1981"},{"key":"ref4","series-title":"J Am Vet Med Assoc","first-page":"1200","article-title":"Effect of penicillin or penicillin and dexamethasone in cattle with infectious bovine keratoconjunctivitis","volume":"206","author":"Allen","year":"1995"},{"key":"ref5","series-title":"Am J Vet Res","first-page":"804","article-title":"Treatment of acute ocular Moraxella bovis infections in calves with a parenterally administered long-acting oxytetracycline formulation","volume":"46","author":"Smith","year":"1985"},{"key":"ref6","series-title":"J Am Vet Med Assoc","first-page":"62","article-title":"Efficacy of florfenicol for treatment of naturally occurring infectious bovine keratoconjunctivitis","volume":"216","author":"Angelos","year":"2000"},{"key":"ref7","series-title":"Am J Vet Res","first-page":"960","article-title":"Efficacy of florfenicol in the treatment of experimentally induced infectious bovine keratoconjunctivitis","volume":"60","author":"Dueger","year":"1999"},{"key":"ref8","series-title":"32nd Annu Conv Am Assoc Bovine Pract","first-page":"261","article-title":"Efficacy of different dosages and routes of inoculation of tilmicosin in a natural outbreak of infectious bovine keratoconjunctivitis, in Proceedings.","volume":"32","author":"Zielinski","year":"1999"},{"key":"ref9","series-title":"Vet Ther","first-page":"60","article-title":"Pharmacokinetics and lung tissue concentrations of tulathromycin, a new triamilide antibiotic, in cattle","volume":"5","author":"Nowakowski","year":"2004"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/229\/4\/javma.229.4.557.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/229\/4\/javma.229.4.557.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/229\/4\/javma.229.4.557.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T13:57:03Z","timestamp":1741355823000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/229\/4\/javma.229.4.557.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,15]]},"references-count":9,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.2460\/javma.229.4.557","relation":{},"ISSN":["0003-1488"],"issn-type":[{"type":"print","value":"0003-1488"}],"subject":[],"published":{"date-parts":[[2006,8,15]]}}}