{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:14:19Z","timestamp":1790007259762,"version":"4.0.1"},"reference-count":31,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2006,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    \u2014To determine whether duration of hospitalization in the intensive care unit (ICU) of a veterinary teaching hospital was associated with prevalence of antimicrobial resistance among rectal\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    isolates from dogs, whether antimicrobial treatment was associated with prevalence of antimicrobial resistance, and whether there were associations among antimicrobial drugs to which isolates were resistant.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design<\/jats:bold>\n                    \u2014Prospective observational study.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Animals<\/jats:bold>\n                    \u2014116 dogs hospitalized in an ICU for \u2265 3 days.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedures<\/jats:bold>\n                    \u2014Rectal swab specimens were obtained every 3 days and submitted for bacterial culture for\n                    <jats:italic>E coli<\/jats:italic>\n                    . Isolates were tested for susceptibility to 12 antimicrobial agents by means of disk diffusion.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u2014For each additional day that a dog was hospitalized in the ICU, the odds of being colonized with an\n                    <jats:italic>E coli<\/jats:italic>\n                    isolate resistant to 1 or more of the 12 antimicrobials tested increased by a factor of 1.5, independent of antimicrobial treatment. Dogs that were treated with enrofloxacin were 25.6 times as likely to be colonized by a quinolone-resistant\n                    <jats:italic>E coli<\/jats:italic>\n                    strain as were dogs that did not receive any antimicrobials. Significant correlations were found for resistance to agents in the extended-spectrum cephalosporin group and the quinolone group.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\n                    \u2014Results suggested that the proportion of rectal\n                    <jats:italic>E coli<\/jats:italic>\n                    isolates obtained from dogs housed for \u2265 3 days in a veterinary teaching hospital ICU that were resistant to antimicrobial agents increased as the duration of hospitalization in the ICU increased. Thus, ICU hospitalization time should be as short as possible to prevent development of antimicrobial resistance among rectal\n                    <jats:italic>E coli<\/jats:italic>\n                    isolates.\n                  <\/jats:p>","DOI":"10.2460\/javma.229.5.694","type":"journal-article","created":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T09:54:45Z","timestamp":1157104485000},"page":"694-699","source":"Crossref","is-referenced-by-count":49,"title":["Development of antimicrobial drug resistance in rectal Escherichia coli isolates from dogs hospitalized in an intensive care unit"],"prefix":"10.2460","volume":"229","author":[{"given":"Jennifer","family":"Ogeer-Gyles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karol A.","family":"Mathews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Sears","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Prescott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"Weese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Boerlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Infect Control Hosp Epidemiol","first-page":"388","article-title":"Antimicrobial use and resistance in eight US hospitals: complexities of analysis and modelling. Intensive Care Antimicrobial Resistance Epidemiology Project and National Nosocomial Infections Surveillance Systems Hospitals","volume":"19","author":"Monnet","year":"1998"},{"key":"ref2","series-title":"Int J Antimicrob Agents","first-page":"327","article-title":"Epidemiology of resistance to antibiotics: links between animals and humans","volume":"14","author":"Van den Bogaard","year":"2000"},{"key":"ref3","series-title":"Infect Control Hosp Epidemiol","first-page":"607","article-title":"Resistance in Enterobacteriaceae: results of a multicenter surveillance study, 1995\u20132000","volume":"24","author":"Friedland","year":"2003"},{"key":"ref4","series-title":"Appl Environ Microbiol","first-page":"5406","article-title":"Long-term shifts in patterns of antibiotic resistance in enteric bacteria","volume":"66","author":"Houndt","year":"2000"},{"key":"ref5","series-title":"Crit Care Med","first-page":"887","article-title":"Nosocomial infections in medical intensive care units in the United States","volume":"27","author":"Richards","year":"1999"},{"key":"ref6","series-title":"J Vet Med","first-page":"569","article-title":"Why is antimicrobial resistance a veterinary problem as well?","volume":"48","author":"Mateu","year":"2001"},{"key":"ref7","series-title":"Aust Vet J","first-page":"82","article-title":"The resistance to chemotherapeutic agents of Escherichia coli from domestic dogs and cats","volume":"61","author":"Moss","year":"1984"},{"key":"ref8","series-title":"Microb Drug Resist","first-page":"65","article-title":"Antibiotic resistance among fecal indicator bacteria from healthy individually owned and kennel dogs","volume":"10","author":"De Graef","year":"2004"},{"key":"ref9","series-title":"Antimicrob Agents Chemother","first-page":"75","article-title":"Orally administered targeted recombinant beta-lactamase prevents ampicillin-induced selective pressure on the gut microbiota: a novel approach to reducing antimicrobial resistance","volume":"48","author":"Harmoinen","year":"2004"},{"key":"ref10","series-title":"J Am Vet Med Assoc","first-page":"368","article-title":"Antimicrobial resistance of Escherichia coli strains isolated from urine of women with cystitis or pyelonephritis and feces of dogs and healthy humans","volume":"225","author":"Sannes","year":"2004"},{"key":"ref11","series-title":"J Med Microbiol","first-page":"439","article-title":"Canine model for investigating the impact of oral enrofloxacin on commensal coliforms and colonization with multidrug-resistant Escherichia coli","volume":"53","author":"Trott","year":"2004"},{"key":"ref12","series-title":"Clinical veterinary microbiology","first-page":"209","article-title":"Enterobacteriaceae","author":"Quinn","year":"1994"},{"key":"ref13","series-title":"Document M31-A","article-title":"Development of in vitro susceptibility testing criteria and quality control parameters for veterinary antimicrobial agents","year":"1999"},{"key":"ref14","series-title":"Document M100-S12","article-title":"Performance standards for antimicrobial susceptibility testing; twelfth international supplement","year":"2002"},{"key":"ref15","series-title":"J Hosp Infect","first-page":"11","article-title":"Risk factors for nosocomial infections caused by gram-negative bacilli. The Hellenic Antibiotic Resistance Study Group","volume":"34","author":"Vatapoulos","year":"1996"},{"key":"ref16","series-title":"Can Med Assoc J","first-page":"885","article-title":"Antimicrobial resistance in Canada","volume":"167","author":"Conly","year":"2002"},{"key":"ref17","series-title":"J Infect","first-page":"307","article-title":"Are infections due to resistant pathogens associated with a worse outcome in critically ill patients?","volume":"47","author":"Peres-Bota","year":"2003"},{"key":"ref18","series-title":"Antimicrob Agents Chemother","first-page":"266","article-title":"Antibiotic resistance and R-factors in the fecal coliform flora of urban and rural dogs","volume":"19","author":"Monaghan","year":"1981"},{"key":"ref19","series-title":"Antimicrob Agents Chemother","first-page":"833","article-title":"Extended-spectrum blactamases in Escherichia coli isolated from dogs and cats in Rome, Italy, from 2001 to 2003","volume":"49","author":"Carattoli","year":"2005"},{"key":"ref20","series-title":"J Am Vet Med Assoc","first-page":"381","article-title":"Nonenteric Escherichia coli isolates from dogs: 674 cases (1990\u20131998)","volume":"218","author":"Oluoch","year":"2001"},{"key":"ref21","series-title":"J Am Anim Hosp Assoc","first-page":"487","article-title":"Antimicrobial susceptibility of selected infectious bacterial agents obtained from dogs","volume":"30","author":"Hirsh","year":"1994"},{"key":"ref22","series-title":"Vet Rec","first-page":"151","article-title":"Trends in antimicrobial resistance in bacterial isolates in a small animal referral hospital","volume":"146","author":"Normand","year":"2000"},{"key":"ref23","series-title":"J Antimicrob Chemother","first-page":"77","article-title":"Patterns and mechanisms of resistance to b-lactams and b-lactamase inhibitors in uropathogenic Escherichia coli isolated from dogs in Portugal","volume":"49","author":"Feria","year":"2002"},{"key":"ref24","series-title":"J Am Anim Hosp Assoc","first-page":"148","article-title":"Nosocomial canine urinary tract infections in a veterinary teaching hospital (1983\u20131988)","volume":"26","author":"Wise","year":"1990"},{"key":"ref25","series-title":"Vet Microbiol","first-page":"73","article-title":"Antimicrobial resistance and resistance gene determinants in clinical Escherichia coli from different animal species in Switzerland","volume":"91","author":"Lanz","year":"2003"},{"key":"ref26","series-title":"Emerg Infect Dis","first-page":"337","article-title":"Emerging mechanisms of fluoroquinolone resistance","volume":"7","author":"Hooper","year":"2001"},{"key":"ref27","series-title":"Antimicrob Agents Chemother","first-page":"3222","article-title":"Mutation rates and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections","volume":"47","author":"Lindgren","year":"2003"},{"key":"ref28","series-title":"Antimicrob Agents Chemother","first-page":"3156","article-title":"b-lactamases in ampicillin-resistant Escherichia coli isolates from foods, humans and healthy animals","volume":"46","author":"Brinas","year":"2002"},{"key":"ref29","series-title":"Appl Environ Microbiol","first-page":"1184","article-title":"Acquisition of resistance to extended-spectrum cephalosporins by Salmonella enterica subsp enterica serovar Newport and Escherichia coli in the turkey poultry intestinal tract","volume":"71","author":"Poppe","year":"2005"},{"key":"ref30","series-title":"Avian Dis","first-page":"351","article-title":"Multiple antimicrobial resistance region of a putative virulence plasmid from an Escherichia coli isolate incriminated in avian colibacillosis","volume":"48","author":"Johnson","year":"2004"},{"key":"ref31","series-title":"FEMS Microbiol Lett","first-page":"285","article-title":"The chloramphenicol 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