{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:52:59Z","timestamp":1787025179021,"version":"build-2736575974"},"reference-count":28,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2006,9,1]]},"abstract":"Abstract<\/jats:title>\n \n Case Description<\/jats:bold>\n \u2014A 4-month-old American Paint Horse colt was evaluated because of acute onset of ataxia, left-sided head tilt, and fever and a recently noticed heart murmur. Upper respiratory tract infection caused by\n Streptococcus equi<\/jats:italic>\n subsp\n equi<\/jats:italic>\n had been diagnosed at 3 months of age.\n <\/jats:p>\n \n Clinical Findings<\/jats:bold>\n \u2014Hematologic abnormalities included leukocytosis, mature neutrophilia, monocytosis, and mild anemia. Analysis of a CSF sample revealed high total protein concentration and total nucleated cell count; nucleated cells consisted mainly of degenerate neutrophils. Results of a real-time PCR assay were positive for\n S equi<\/jats:italic>\n subsp\n equi<\/jats:italic>\n , and a diagnosis of\n S equi<\/jats:italic>\n subsp\n equi<\/jats:italic>\n meningoencephalomyelitis was made.\n <\/jats:p>\n \n Treatment and Outcome<\/jats:bold>\n \u2014Treatment included administration of potassium penicillin and fluids, but the foal developed uroperitoneum and was subsequently euthanized. Postmortem examination revealed meningoencephalomyelitis, and\n S equi<\/jats:italic>\n subsp\n equi<\/jats:italic>\n was cultured from a brain aspirate. Additional findings included suppurative cystitis with rupture and neutrophilic myocarditis.\n <\/jats:p>\n \n Clinical Relevance<\/jats:bold>\n \u2014Findings suggest that\n S equi<\/jats:italic>\n subsp\n equi<\/jats:italic>\n meningoencephalomyelitis should be considered in the differential diagnosis for foals with neurologic signs that have a history of strangles or exposure to affected horses.\n <\/jats:p>","DOI":"10.2460\/javma.229.5.721","type":"journal-article","created":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T09:54:45Z","timestamp":1157104485000},"page":"721-724","source":"Crossref","is-referenced-by-count":22,"title":["Streptococcus equi meningoencephalomyelitis in a foal"],"prefix":"10.2460","volume":"229","author":[{"given":"Carrie","family":"Finno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Pusterla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Aleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Charles","family":"Mohr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teena","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Holmberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Compend Contin Educ Pract Vet","first-page":"479","article-title":"Equine bacterial meningitis\u2014part 1","volume":"11","author":"Santschi","year":"1989"},{"key":"ref2","series-title":"Aust Vet J","first-page":"445","article-title":"A survey of neurological diseases in horses","volume":"70","author":"Tyler","year":"1993"},{"key":"ref3","series-title":"Vet Rec","first-page":"68","article-title":"Streptococcus suis meningitis in a 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