{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T18:21:24Z","timestamp":1780510884219,"version":"3.54.1"},"reference-count":50,"publisher":"American Veterinary Medical Association (AVMA)","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To establish a reference interval for a feline-specific pancreatic lipase assay (Spec fPL test; Idexx Laboratories Inc) in healthy cats and determine the sensitivity and specificity of the Spec fPL test in a large group of ill cats with and without pancreatitis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>41 healthy cats, 141 cats with clinical signs consistent with pancreatitis, and 786 stored sera with known feline pancreatic lipase immunoreactivity (fPLI) concentrations.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>This was a prospective, cross-sectional, nonrandomized study. Based on a detailed review of the medical history and results of physical examination, CBC, serum biochemical profile, urinalysis, abdominal ultrasonography, and clinical outcome, each cat was categorized by 2 board-certified internists masked to the fPLI test results into 1 of 6 categories from definitely pancreatitis to definitely not pancreatitis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>The reference interval for the Spec fPL test, determined from the central 95th percentile of results from healthy cats, was fPLI of 0.7 to 3.5 \u00b5g\/L. An fPLI concentration of \u2265 5.4 \u00b5g\/L was determined to be consistent with pancreatitis. With an fPLI of 5.4 \u00b5g\/L as the diagnostic cutoff, the sensitivity of the Spec fPL test for feline pancreatitis (definitely pancreatitis and probably pancreatitis) was 79.4%, the specificity for cats characterized as probably not pancreatitis and definitely not pancreatitis was 79.7%, and positive and negative predictive values were 69% and 87%, respectively.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>These findings support the use of the Spec fPL test as a valuable diagnostic test for feline pancreatitis.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.23.02.0105","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T22:16:38Z","timestamp":1697235398000},"page":"42-52","source":"Crossref","is-referenced-by-count":5,"title":["Measurement of feline-specific pancreatic lipase aids in the diagnosis of pancreatitis in cats"],"prefix":"10.2460","volume":"262","author":[{"given":"Marnin A.","family":"Forman","sequence":"first","affiliation":[{"name":"Cornell University Veterinary Specialists, Stamford, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane E.","family":"Robertson","sequence":"additional","affiliation":[{"name":"Idexx Laboratories Inc, West Sacramento, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan T.","family":"Shiroma","sequence":"additional","affiliation":[{"name":"MedVet, Medical and Cancer Center for Pets, Worthington, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger A.","family":"Hostutler","sequence":"additional","affiliation":[{"name":"MedVet, Medical and Cancer Center for Pets, Worthington, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth W.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Estrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley J.","family":"Newman","sequence":"additional","affiliation":[{"name":"Newman Specialty VetPath, Hicksville, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie C.","family":"Corn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Buch","sequence":"additional","affiliation":[{"name":"Idexx Laboratories Inc, Westbrook, ME"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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