{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T19:02:41Z","timestamp":1777057361378,"version":"3.51.4"},"reference-count":15,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To retrospectively evaluate the prevalence and clinical progression of wobbly hedgehog syndrome (WHS) and concurrent incidence of neoplasia in a cohort of African pygmy hedgehogs (<jats:italic>Atelerix albiventris<\/jats:italic>).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>49 hedgehogs.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL PRESENTATION AND PROCEDURES<\/jats:title>\n<jats:p>Medical records of hedgehogs from 7 institutions across the US over a 20-year period (2000 to 2020) were retrospectively reviewed. Inclusion criteria were hedgehogs of any sex or age with postmortem CNS histopathology consistent with WHS. Collected data included sex, age at onset and euthanasia, major histopathologic findings, reported neurologic clinical signs, and treatments administered.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>24 males and 25 females were included. Fifteen of 49 (31%) individuals had subclinical WHS with no reported antemortem neurologic clinical signs. In neurologically affected (clinical) hedgehogs (n = 34), the mean \u00b1 SD age at onset was 3.3 \u00b1 1.5 years with a median (range) time from onset to euthanasia of 51 days (1 to 319 days). In neurologically affected hedgehogs, the most commonly reported clinical signs were ataxia (n = 21) and pelvic limb paresis (16) and the most commonly administered treatment was meloxicam (13). Overall, 31 of 49 (63%) hedgehogs had a concurrent histopathologic diagnosis of neoplasia outside of the CNS.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>The prognosis for hedgehogs with WHS is poor. No treatment had a significant effect on survival time, and neoplasia was a common comorbidity in the current cohort. A small but clinically relevant subset of neurologically normal hedgehogs had a histopathologic diagnosis of WHS.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.23.03.0167","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T12:26:18Z","timestamp":1684758378000},"page":"1-6","source":"Crossref","is-referenced-by-count":2,"title":["Retrospective evaluation of wobbly hedgehog syndrome in 49 African pygmy hedgehogs (Atelerix albiventris): 2000\u20132020"],"prefix":"10.2460","volume":"261","author":[{"given":"Gabriela A.","family":"Gonzalez","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A.","family":"Balko","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miranda J.","family":"Sadar","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy B.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Department of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie D.","family":"Sheldon","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grayson A.","family":"Doss","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krista A.","family":"Keller","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara M.","family":"Gardhouse","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia A.","family":"Petritz","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"1","key":"ref1","series-title":"J Exot Pet Med","first-page":"59","article-title":"Wobbly hedgehog syndrome in African pygmy hedgehogs (Atelerix spp.)","volume":"15","author":"Graesser D","year":"2006","unstructured":"Graesser D, Spraker TR, Dressen P,  Wobbly hedgehog syndrome in African pygmy hedgehogs (Atelerix spp.). J Exot Pet Med. 2006;15(1):59-65. doi:10.1053\/j.jepm.2005.11.010"},{"issue":"1","key":"ref2","series-title":"Emerg Infect Dis","first-page":"1","article-title":"Hedgehog zoonoses","volume":"11","author":"Riley PY","year":"2005","unstructured":"Riley PY, Chomel BB. Hedgehog zoonoses. Emerg Infect Dis. 2005;11(1):1-5. doi:10.3201\/eid1101.040752"},{"issue":"1","key":"ref3","series-title":"J Exot Pet Med","first-page":"105","article-title":"A retrospective study of the medical status on 63 African hedgehogs (Atelerix albiventris) at the Taipei zoo from 2003 to 2011","volume":"24","author":"Pei-Chi H","year":"2015","unstructured":"Pei-Chi H, Jane-Fang Y, Lih-Chiann W. A retrospective study of the medical status on 63 African hedgehogs (Atelerix albiventris) at the Taipei zoo from 2003 to 2011. J Exot Pet Med. 2015;24(1):105-111. doi:10.1053\/j.jepm.2014.11.003"},{"issue":"5","key":"ref4","series-title":"J Vet Diagn Invest","first-page":"468","article-title":"Cardiomyopathy in captive African hedgehogs (Atelerix albiventris)","volume":"12","author":"Raymond JT","year":"2000","unstructured":"Raymond JT, Garner MM. Cardiomyopathy in captive African hedgehogs (Atelerix albiventris). J Vet Diagn Invest. 2000;12(5):468-472. doi:10.1177\/104063870001200516"},{"issue":"5","key":"ref5","series-title":"Vet Pathol","first-page":"711","article-title":"The pathology of wobbly hedgehog syndrome","volume":"55","author":"D\u00edaz-Delgado J","year":"2018","unstructured":"D\u00edaz-Delgado J, Whitley DB, Storts RW, Heatley JJ, Hoppes S, Porter BF. The pathology of wobbly hedgehog syndrome. Vet Pathol. 2018;55(5):711-718. doi:10.1177\/0300985818768033"},{"issue":"1","key":"ref6","series-title":"Cienc Rural","first-page":"e20180742","article-title":"Wobbly syndrome in an Africa pygmy hedgehog (Atelerix albiventris): neuropathological and immunohistochemical studies","volume":"49","author":"Batelli de Oliveira L","year":"2019","unstructured":"Batelli de Oliveira L, Moreira MVL, de Magalh\u00e3es Santos WH,  Wobbly syndrome in an Africa pygmy hedgehog (Atelerix albiventris): neuropathological and immunohistochemical studies. Cienc Rural. 2019;49(1):e20180742. doi:10.1590\/0103-8478cr20180742"},{"key":"ref7","series-title":"Isr J Vet Med","first-page":"32","article-title":"Retrospective study of disease occurrence in captive African pygmy hedgehogs (Atelerix albiventris)","volume":"70","author":"Gardhouse S","year":"2015","unstructured":"Gardhouse S, Eshar D. Retrospective study of disease occurrence in captive African pygmy hedgehogs (Atelerix albiventris). Isr J Vet Med. 2015;70:32-36."},{"issue":"11","key":"ref8","series-title":"Animals (Basel)","first-page":"1361","article-title":"Pathological findings in African pygmy hedgehogs admitted into a Portuguese rehabilitation center","volume":"12","author":"Silva GF","year":"2022","unstructured":"Silva GF, R\u00eama A, Teixeira S, Pires MDA, Taulescu M, Amorim I. Pathological findings in African pygmy hedgehogs admitted into a Portuguese rehabilitation center. Animals (Basel). 2022;12(11):1361. doi:10.3390\/ani12111361"},{"issue":"3","key":"ref9","series-title":"Animals (Basel)","first-page":"258","article-title":"A multi-institutional collaboration to understand neoplasia, treatment and survival of snakes","volume":"12","author":"Duke EG","year":"2022","unstructured":"Duke EG, Harrison SH, Moresco A,  A multi-institutional collaboration to understand neoplasia, treatment and survival of snakes. Animals (Basel). 2022;12(3):258. doi:10.3390\/ani12030258"},{"key":"ref10","series-title":"Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery","first-page":"401","article-title":"African pygmy hedgehogs","author":"Doss G","year":"2021","unstructured":"Doss G, Carpenter JW. African pygmy hedgehogs. In: Quesenberry K, Orcutt K, Mans C, , eds. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery. 4th ed. Elsevier; 2021:401-415."},{"issue":"3","key":"ref11","series-title":"Vet Clin North Am Exot Anim Pract","first-page":"615","article-title":"Geriatric hedgehogs","volume":"23","author":"Johnson DH","year":"2020","unstructured":"Johnson DH. Geriatric hedgehogs. Vet Clin North Am Exot Anim Pract. 2020;23(3):615-637. doi:10.1016\/j.cvex.2020.05.005"},{"issue":"3","key":"ref12","series-title":"J Exot Pet Med","first-page":"182","article-title":"A review of neoplasia in the captive African hedgehog (Atelerix albiventris)","volume":"14","author":"Heatley JJ","year":"2005","unstructured":"Heatley JJ, Mauldin GE, Cho DY. A review of neoplasia in the captive African hedgehog (Atelerix albiventris). J Exot Pet Med. 2005;14(3):182-192. doi:10.1053\/j.saep.2005.07.002"},{"issue":"3","key":"ref13","series-title":"Vet Clin North Am Exot Anim Pract","first-page":"627","article-title":"Spontaneous tumors of small mammals","volume":"7","author":"Greenacre CB","year":"2004","unstructured":"Greenacre CB. Spontaneous tumors of small mammals. Vet Clin North Am Exot Anim Pract. 2004;7(3):627-651, vi. doi:10.1016\/j.cvex.2004.04.009"},{"issue":"15","key":"ref14","series-title":"Cancers (Basel)","first-page":"3722","article-title":"Emerging roles of the nervous system in gastrointestinal cancer development","volume":"14","author":"Wan C","year":"2022","unstructured":"Wan C, Yan X, Hu B, Zhang X. Emerging roles of the nervous system in gastrointestinal cancer development. Cancers (Basel). 2022;14(15):3722. doi:10.3390\/cancers14153722"},{"issue":"10","key":"ref15","series-title":"J Clin Invest","first-page":"131","article-title":"Exploiting unique features of the gut-brain interface to combat gastrointestinal cancer","volume":"131","author":"Schledwitz A","year":"2021","unstructured":"Schledwitz A, Xie G, Raufman J-P. Exploiting unique features of the gut-brain interface to combat gastrointestinal cancer. J Clin Invest. 2021;131(10):131. doi:10.1172\/JCI143776"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/261\/9\/javma.23.03.0167.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/261\/9\/javma.23.03.0167.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/261\/9\/javma.23.03.0167.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T13:02:06Z","timestamp":1741352526000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/261\/9\/javma.23.03.0167.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,1]]},"references-count":15,"journal-issue":{"issue":"9"},"URL":"https:\/\/doi.org\/10.2460\/javma.23.03.0167","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9,1]]}}}