{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:53:45Z","timestamp":1777604025801,"version":"3.51.4"},"reference-count":23,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To evaluate patient and vaccine factors associated with adverse events (AEs) recorded within 3 days of vaccine administration in a large cohort of dogs.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>4,654,187 dogs vaccinated in 16,087,455 office visits in a 5-year period at 1,119 hospitals of a corporate practice.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Electronic medical records of dogs vaccinated between January 1, 2016, and December 31, 2020, were searched for diagnoses of possible AEs recorded within 3 days of administration of vaccines without concurrent injectable heartworm preventative. Patient risk factors (age, sex, breed, and weight) and number and type of vaccine were extracted from records. ORs (and 95% CIs) for risk factors were estimated via multivariable logistic regression mixed models with patient as a random effect.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>AEs were recorded following 31,197 vaccination visits (0.19%, or 19.4\/10,000 visits). Reported AE rates increased from 1 to 4 vaccines administered and among individual vaccines were greatest for rabies vaccine. AE rate was generally inversely related to body weight, with largest rates in dogs \u2264 5 kg. The largest AE rates were noted in French Bulldogs and Dachshunds (ORs &gt; 4 compared to mixed-breed dogs).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Risk factor information can be used to update vaccination protocols and client communication. Breed differences may indicate genetics as the primary risk factor for adverse vaccine reactions following vaccinations.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.23.03.0181","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T17:35:02Z","timestamp":1689356102000},"page":"1653-1659","source":"Crossref","is-referenced-by-count":9,"title":["Breed, smaller weight, and multiple injections are associated with increased adverse event reports within three days following canine vaccine administration"],"prefix":"10.2460","volume":"261","author":[{"given":"George E.","family":"Moore","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Purdue University, West Lafayette, IN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JoAnn","family":"Morrison","sequence":"additional","affiliation":[{"name":"Banfield Pet Hospital, Vancouver, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emi K.","family":"Saito","sequence":"additional","affiliation":[{"name":"Banfield Pet Hospital, Vancouver, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathaniel","family":"Spofford","sequence":"additional","affiliation":[{"name":"Banfield Pet Hospital, Vancouver, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Yang","sequence":"additional","affiliation":[{"name":"Banfield Pet Hospital, Vancouver, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"12","key":"ref1","series-title":"J Am Vet Med Assoc","first-page":"1482","article-title":"Canine and feline core vaccinations: US veterinarians\u2019 concerns and perceived impact of COVID-19 antivaccination views on veterinary medicine","volume":"260","author":"Kogan LR","year":"2022","unstructured":"Kogan LR, Rishniw M. Canine and feline core vaccinations: US veterinarians\u2019 concerns and perceived impact of COVID-19 antivaccination views on veterinary medicine. J Am Vet Med Assoc. 2022;260(12):1482-1488. doi:10.2460\/javma.22.03.0109"},{"issue":"3","key":"ref2","series-title":"Vaccines (Basel)","first-page":"480","article-title":"Determinants of vaccination uptake in risk populations: a comprehensive literature review","volume":"8","author":"Doornekamp L","year":"2020","unstructured":"Doornekamp L, van Leeuwen L, van Gorp E, Voeten H, Goeijenbier M. Determinants of vaccination uptake in risk populations: a comprehensive literature review. Vaccines (Basel). 2020;8(3):480. doi:10.3390\/vaccines8030480"},{"issue":"3","key":"ref3","series-title":"Vet Clin North Am Small Anim Pract","first-page":"393","article-title":"Adverse vaccinal events in dogs and cats","volume":"40","author":"Moore GE","year":"2010","unstructured":"Moore GE, HogenEsch H. Adverse vaccinal events in dogs and cats. Vet Clin North Am Small Anim Pract. 2010;40(3):393-407. doi:10.1016\/j.cvsm.2010.02.002"},{"issue":"36","key":"ref4","series-title":"Vaccine","first-page":"5350","article-title":"Personalized vaccinology: a review","volume":"36","author":"Poland GA","year":"2018","unstructured":"Poland GA, Ovsyannikova IG, Kennedy RB. Personalized vaccinology: a review. Vaccine. 2018;36(36):5350-5357. doi:10.1016\/j.vaccine.2017.07.062"},{"issue":"4 suppl 2","key":"ref5","series-title":"Ann Allergy Asthma Immunol","first-page":"S1","article-title":"Joint Task Force on Practice Parameters; Joint Task Force on Practice Parameters for Allergy and Immunology. Adverse reactions to vaccines","volume":"103","author":"Kelso JM","year":"2009","unstructured":"Kelso JM, Li JT, Nicklas RA, ; Joint Task Force on Practice Parameters; Joint Task Force on Practice Parameters for Allergy and Immunology. Adverse reactions to vaccines. Ann Allergy Asthma Immunol. 2009;103(4 suppl 2):S1-S14. doi:10.1016\/s1081-1206(10)60350-x"},{"issue":"3-4","key":"ref6","series-title":"Vet Immunol Immunopathol","first-page":"249","article-title":"IgE reactivity to vaccine components in dogs that developed immediate-type allergic reactions after vaccination","volume":"104","author":"Ohmori K","year":"2005","unstructured":"Ohmori K, Masuda K, Maeda S,  IgE reactivity to vaccine components in dogs that developed immediate-type allergic reactions after vaccination. Vet Immunol Immunopathol. 2005;104(3-4):249-256. doi:10.1016\/j.vetimm.2004.12.003"},{"issue":"3","key":"ref7","series-title":"Am J Vet Res","first-page":"ajvr.22.11.0192","article-title":"Proteomic analysis of canine vaccines","volume":"84","author":"Franco J","year":"2023","unstructured":"Franco J, Aryal UK, HogenEsch H, Moore GE. Proteomic analysis of canine vaccines. Am J Vet Res. 2023;84(3):ajvr.22.11.0192. Published 2023 Jan 24. doi:10.2460\/ajvr.22.11.0192"},{"issue":"7","key":"ref8","series-title":"J Am Vet Med Assoc","first-page":"1102","article-title":"Adverse events diagnosed within three days of vaccine administration in dogs","volume":"227","author":"Moore GE","year":"2005","unstructured":"Moore GE, Guptill LF, Ward MP,  Adverse events diagnosed within three days of vaccine administration in dogs. J Am Vet Med Assoc. 2005;227(7):1102-1108. doi:10.2460\/javma.2005.227.1102"},{"issue":"5","key":"ref9","series-title":"J Am Anim Hosp Assoc","first-page":"1","article-title":"American Animal Hospital Association Canine Vaccination Task Force. 2011 AAHA canine vaccination guidelines","volume":"47","author":"Welborn LV","year":"2011","unstructured":"Welborn LV, DeVries JG, Ford R, ; American Animal Hospital Association Canine Vaccination Task Force. 2011 AAHA canine vaccination guidelines. J Am Anim Hosp Assoc. 2011;47(5):1-42. doi:10.5326\/jaaha-ms-4000"},{"issue":"1","key":"ref10","series-title":"J Small Anim Pract","first-page":"E1","article-title":"Vaccination Guidelines Group of the World Small Animal Veterinary Association. WSAVA guidelines for the vaccination of dogs and cats","volume":"57","author":"Day MJ","year":"2016","unstructured":"Day MJ, Horzinek MC, Schultz RD, Squires RA; Vaccination Guidelines Group of the World Small Animal Veterinary Association. WSAVA guidelines for the vaccination of dogs and cats. J Small Anim Pract. 2016;57(1):E1-E45. doi:10.1111\/jsap.2_12431"},{"issue":"2","key":"ref11","series-title":"Int J Appl Res Vet Med","first-page":"49","article-title":"Safety profile of moxidectin (ProHeart 6) and two oral heartworm preventives in dogs","volume":"3","author":"Glickman LT","year":"2005","unstructured":"Glickman LT, Glickman NW, Moore GE,  Safety profile of moxidectin (ProHeart 6) and two oral heartworm preventives in dogs. Int J Appl Res Vet Med. 2005;3(2):49-61."},{"key":"ref12","series-title":"Prev Vet Med","first-page":"38","article-title":"Disease burden in four populations of dog and cat breeds compared to mixed-breed dogs and European shorthair cats","volume":"140","author":"Keijser SFA","year":"2017","unstructured":"Keijser SFA, Meijndert LE, Fieten H,  Disease burden in four populations of dog and cat breeds compared to mixed-breed dogs and European shorthair cats. Prev Vet Med. 2017;140:38-44. doi:10.1016\/j.prevetmed.2017.02.016"},{"issue":"5","key":"ref13","series-title":"J Am Anim Hosp Assoc","first-page":"213","article-title":"2022 AAHA canine vaccination guidelines","volume":"58","author":"Ellis J","year":"2022","unstructured":"Ellis J, Marziani E, Aziz C,  2022 AAHA canine vaccination guidelines. J Am Anim Hosp Assoc. 2022;58(5):213-230. doi:10.5326\/JAAHA-MS-Canine-Vaccination-Guidelines"},{"issue":"7","key":"ref14","series-title":"Vaccine","first-page":"1018","article-title":"Vaccine shot-limiting: estimating the prevalence, indicators, and impact on vaccination status - Michigan, 2012","volume":"35","author":"Weinberg M","year":"2017","unstructured":"Weinberg M, Dietz S, Potter R, Swanson R, Miller C, McFadden J. Vaccine shot-limiting: estimating the prevalence, indicators, and impact on vaccination status - Michigan, 2012. Vaccine. 2017;35(7):1018-1023. doi:10.1016\/j.vaccine.2017.01.013"},{"issue":"5","key":"ref15","series-title":"Vaccine","first-page":"765","article-title":"Vaccine timeliness and prevalence of undervaccination patterns in children ages 0-19 months, US, National Immunization Survey-Child 2017","volume":"40","author":"Freeman RE","year":"2022","unstructured":"Freeman RE, Thaker J, Daley MF, Glanz JM, Newcomer SR. Vaccine timeliness and prevalence of undervaccination patterns in children ages 0-19 months, US, National Immunization Survey-Child 2017. Vaccine. 2022;40(5):765-773. doi:10.1016\/j.vaccine.2021.12.037"},{"issue":"1","key":"ref16","series-title":"Vet Clin North Am Small Anim Pract","first-page":"99","article-title":"Ischemic dermatopathies","volume":"43","author":"Morris DO","year":"2013","unstructured":"Morris DO. Ischemic dermatopathies. Vet Clin North Am Small Anim Pract. 2013;43(1):99-111. doi:10.1016\/j.cvsm.2012.09.008"},{"issue":"8","key":"ref17","series-title":"J Vet Med Sci","first-page":"1202","article-title":"Anaphylaxis after rabies vaccination for dogs in Japan","volume":"83","author":"Yoshida M","year":"2021","unstructured":"Yoshida M, Mizukami K, Hisasue M,  Anaphylaxis after rabies vaccination for dogs in Japan. J Vet Med Sci. 2021;83(8):1202-1205. doi:10.1292\/jvms.21-0090"},{"issue":"10","key":"ref18","series-title":"Nat Rev Immunol","first-page":"626","article-title":"Sex differences in immune responses","volume":"16","author":"Klein SL","year":"2016","unstructured":"Klein SL, Flanagan KL. Sex differences in immune responses. Nat Rev Immunol. 2016;16(10):626-638. doi:10.1038\/nri.2016.90"},{"key":"ref19","series-title":"Front Immunol","first-page":"2279","article-title":"Sex hormones in acquired immunity and autoimmune disease","volume":"9","author":"Moulton VR","year":"2018","unstructured":"Moulton VR. Sex hormones in acquired immunity and autoimmune disease. Front Immunol. 2018;9:2279. doi:10.3389\/fimmu.2018.02279"},{"key":"ref20","series-title":"Curr Opin Pharmacol","first-page":"122","article-title":"Effect of sex on vaccination outcomes: important but frequently overlooked","volume":"41","author":"Harper A","year":"2018","unstructured":"Harper A, Flanagan KL. Effect of sex on vaccination outcomes: important but frequently overlooked. Curr Opin Pharmacol. 2018;41:122-127. doi:10.1016\/j.coph.2018.05.009"},{"issue":"5","key":"ref21","series-title":"Am J Vet Res","first-page":"762","article-title":"Concentrations of luteinizing hormone and follicle-stimulating hormone in the serum of sexually intact and neutered dogs","volume":"53","author":"Olson PN","year":"1992","unstructured":"Olson PN, Mulnix JA, Nett TM. Concentrations of luteinizing hormone and follicle-stimulating hormone in the serum of sexually intact and neutered dogs. Am J Vet Res. 1992;53(5):762-766."},{"issue":"4","key":"ref22","series-title":"Am J Vet Res","first-page":"611","article-title":"Effect of vaccination on serum concentrations of total and antigen-specific immunoglobulin E in dogs","volume":"63","author":"HogenEsch H","year":"2002","unstructured":"HogenEsch H, Dunham AD, Scott-Moncrieff C, Glickman LT, DeBoer DJ. Effect of vaccination on serum concentrations of total and antigen-specific immunoglobulin E in dogs. Am J Vet Res. 2002;63(4):611-616. doi:10.2460\/ajvr.2002.63.611"},{"issue":"1","key":"ref23","series-title":"Expert Rev Vaccines","first-page":"21","article-title":"Vaccine safety surveillance using large linked databases: opportunities, hazards and proposed guidelines","volume":"2","author":"Verstraeten T","year":"2003","unstructured":"Verstraeten T, DeStefano F, Chen RT, Miller E. Vaccine safety surveillance using large linked databases: opportunities, hazards and proposed guidelines. 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