{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:34:40Z","timestamp":1768293280921,"version":"3.49.0"},"reference-count":41,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To identify the frequency of and risk factors for acute kidney injury (AKI) in dogs undergoing abdominal surgery for septic peritonitis, and to evaluate outcome and kidney-related risk factors for survival to discharge in those dogs.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>77 dogs that underwent abdominal surgery for septic peritonitis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Medical records of dogs that underwent surgery for septic peritonitis from 2012 through 2022 were reviewed. Data regarding signalment, clinical and biochemical findings at presentation, blood creatinine concentration throughout hospitalization, surgery characteristics, postoperative monitoring, and outcome were collected. Dogs were classified based on occurrence of AKI and whether they presented with or developed AKI in-hospital. Perioperative risk factors were evaluated, and outcomes were compared with univariable logistic regression.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>31 dogs (40.3%) had AKI diagnosed; 18\/77 (23.4%) dogs presented with AKI, 11 (61.1%) of which had it postoperatively, and 13\/77 (16.9%) dogs developed AKI postoperatively. Significant factors for presenting with AKI included increasing baseline respiratory rate (OR 2.5 for every 10 beats per minute higher), decreasing systolic blood pressure (OR 0.8 for every 10 mm Hg higher), and increasing body condition score (OR 2.2 for every score greater). No significant factors for developing AKI postoperatively were identified after multiple comparisons adjustment. Sixteen dogs (20.8%) did not survive to discharge; 12 (75.0%) had AKI and 4 (25.0%) did not. Dogs with AKI had decreased odds of survival to discharge (OR 0.2).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>AKI was common in dogs with septic peritonitis and was a significant risk factor for survival to discharge. Clinical surveillance of AKI is critical in this population.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.23.04.0184","type":"journal-article","created":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T12:19:11Z","timestamp":1692101951000},"page":"1-10","source":"Crossref","is-referenced-by-count":5,"title":["Acute kidney injury is common in dogs with septic peritonitis and is associated with increased mortality"],"prefix":"10.2460","volume":"261","author":[{"given":"Mary M.","family":"Snipes","sequence":"first","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad W.","family":"Schmiedt","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca N.","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet A.","family":"Grimes","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandy L.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J.","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin M.","family":"Brainard","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"7","key":"ref1","series-title":"JAMA","first-page":"813","article-title":"Acute renal failure in critically ill patients: a multinational, multicenter study","volume":"294","author":"Uchino S","year":"2005","unstructured":"Uchino S, Kellum JA, Bellomo R,  Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA. 2005;294(7):813-818."},{"issue":"3","key":"ref2","series-title":"Clin J Am Soc Nephrol","first-page":"431","article-title":"Septic acute kidney injury in critically ill patients: clinical characteristics and outcomes","volume":"2","author":"Bagshaw SM","year":"2007","unstructured":"Bagshaw SM, Uchino S, Bellomo R,  Septic acute kidney injury in critically ill patients: clinical characteristics and outcomes. Clin J Am Soc Nephrol. 2007;2(3):431-439."},{"issue":"8","key":"ref3","series-title":"Intensive Care Med","first-page":"1411","article-title":"Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study","volume":"41","author":"Hoste EA","year":"2015","unstructured":"Hoste EA, Bagshaw SM, Bellomo R,  Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med. 2015;41(8):1411-1423."},{"issue":"1","key":"ref4","series-title":"J Am Vet Med Assoc","first-page":"83","article-title":"Association between outcome and organ system dysfunction in dogs with sepsis: 114 cases (2003-2007)","volume":"236","author":"Kenney EM","year":"2010","unstructured":"Kenney EM, Rozanski EA, Rush JE,  Association between outcome and organ system dysfunction in dogs with sepsis: 114 cases (2003-2007). J Am Vet Med Assoc. 2010;236(1):83-87."},{"issue":"6","key":"ref5","series-title":"J Feline Med Surg","first-page":"559","article-title":"Multiorgan dysfunction syndrome in feline sepsis: prevalence and prognostic implication","volume":"21","author":"Tro\u00eca R","year":"2019","unstructured":"Tro\u00eca R, Mascalzoni G, Calipa S, Magagnoli I, Dondi F, Giunti M. Multiorgan dysfunction syndrome in feline sepsis: prevalence and prognostic implication. J Feline Med Surg. 2019;21(6):559-565."},{"issue":"2","key":"ref6","series-title":"J Vet Emerg Crit Care (San Antonio)","first-page":"200","article-title":"Acute kidney injury in severe sepsis: pathophysiology, diagnosis, and treatment recommendations","volume":"25","author":"Keir I","year":"2015","unstructured":"Keir I, Kellum JA. Acute kidney injury in severe sepsis: pathophysiology, diagnosis, and treatment recommendations. J Vet Emerg Crit Care (San Antonio). 2015;25(2):200-209."},{"issue":"6","key":"ref7","series-title":"Curr Opin Crit Care","first-page":"588","article-title":"Sepsis-induced acute kidney injury revisited: pathophysiology, prevention and future therapies","volume":"20","author":"Zarbock A","year":"2014","unstructured":"Zarbock A, Gomez H, Kellum JA. Sepsis-induced acute kidney injury revisited: pathophysiology, prevention and future therapies. Curr Opin Crit Care. 2014;20(6):588-595."},{"issue":"3","key":"ref8","series-title":"Blood Purif","first-page":"216","article-title":"Renal blood flow during acute renal failure in man","volume":"28","author":"Prowle JR","year":"2009","unstructured":"Prowle JR, Ishikawa K, May CN, Bellomo R. Renal blood flow during acute renal failure in man. Blood Purif. 2009;28(3):216-225."},{"issue":"6","key":"ref9","series-title":"PLoS One","first-page":"e35838","article-title":"A multicentre study of acute kidney injury in severe sepsis and septic shock: association with inflammatory phenotype and HLA genotype","volume":"7","author":"Payen D","year":"2012","unstructured":"Payen D, Lukaszewicz AC, Legrand M,  A multicentre study of acute kidney injury in severe sepsis and septic shock: association with inflammatory phenotype and HLA genotype. PLoS One. 2012;7(6):e35838."},{"issue":"6","key":"ref10","series-title":"Kidney Int","first-page":"527","article-title":"Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival","volume":"77","author":"Murugan R","year":"2010","unstructured":"Murugan R, Karajala-Subramanyam V, Lee M,  Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival. Kidney Int. 2010;77(6):527-535."},{"issue":"14","key":"ref11","series-title":"Opt Express","first-page":"15054","article-title":"Real-time assessment of renal cortical microvascular perfusion heterogeneities using near-infrared laser speckle imaging","volume":"18","author":"Bezemer R","year":"2010","unstructured":"Bezemer R, Legrand M, Klijn E,  Real-time assessment of renal cortical microvascular perfusion heterogeneities using near-infrared laser speckle imaging. Opt Express. 2010;18(14):15054-15061."},{"issue":"Suppl 2","key":"ref12","series-title":"Br J Anaesth","first-page":"ii3","article-title":"Perioperative acute kidney injury","volume":"115","author":"Goren O","year":"2015","unstructured":"Goren O, Matot I. Perioperative acute kidney injury. Br J Anaesth. 2015;115(Suppl 2):ii3-ii14."},{"issue":"2","key":"ref13","series-title":"Nephron","first-page":"105","article-title":"Perioperative acute kidney injury: prevention, early recognition, and supportive measures","volume":"140","author":"Romagnoli S","year":"2018","unstructured":"Romagnoli S, Ricci Z, Ronco C. Perioperative acute kidney injury: prevention, early recognition, and supportive measures. Nephron. 2018;140(2):105-110."},{"issue":"3","key":"ref14","series-title":"Vet Clin North Am Small Anim Pract","first-page":"659","article-title":"Acute kidney injury in dogs and cats","volume":"52","author":"Ross L","year":"2022","unstructured":"Ross L. Acute kidney injury in dogs and cats. Vet Clin North Am Small Anim Pract. 2022;52(3):659-672."},{"issue":"2","key":"ref15","series-title":"J Vet Intern Med","first-page":"609","article-title":"Acute kidney injury in dogs: etiology, clinical and clinicopathologic findings, prognostic markers, and outcome","volume":"36","author":"Rimer D","year":"2022","unstructured":"Rimer D, Chen H, Bar-Nathan M, Segev G. Acute kidney injury in dogs: etiology, clinical and clinicopathologic findings, prognostic markers, and outcome. J Vet Intern Med. 2022;36(2):609-618."},{"issue":"4","key":"ref16","series-title":"Am J Kidney Dis","first-page":"551","article-title":"Risk of ESRD and mortality associated with change in filtration markers","volume":"70","author":"Rebholz CM","year":"2017","unstructured":"Rebholz CM, Inker LA, Chen Y,  Risk of ESRD and mortality associated with change in filtration markers. Am J Kidney Dis. 2017;70(4):551-560."},{"issue":"2","key":"ref17","series-title":"Vet Surg","first-page":"174","article-title":"Seim HB 3rd. Open peritoneal drainage versus primary closure for the treatment of septic peritonitis in dogs and cats: 42 cases (1993-1999)","volume":"31","author":"Staatz AJ","year":"2002","unstructured":"Staatz AJ, Monnet E, Seim HB 3rd. Open peritoneal drainage versus primary closure for the treatment of septic peritonitis in dogs and cats: 42 cases (1993-1999). Vet Surg. 2002;31(2):174-180."},{"issue":"1","key":"ref18","series-title":"J Am Vet Med Assoc","first-page":"73","article-title":"Risk factors for leakage following intestinal anastomosis in dogs and cats: 115 cases (1991-2000)","volume":"223","author":"Ralphs SC","year":"2003","unstructured":"Ralphs SC, Jessen CR, Lipowitz AJ. Risk factors for leakage following intestinal anastomosis in dogs and cats: 115 cases (1991-2000). J Am Vet Med Assoc. 2003;223(1):73-77."},{"issue":"4","key":"ref19","series-title":"J Am Vet Med Assoc","first-page":"486","article-title":"Identification of risk factors for septic peritonitis and failure to survive following gastrointestinal surgery in dogs","volume":"238","author":"Grimes JA","year":"2011","unstructured":"Grimes JA, Schmiedt CW, Cornell KK, Radlinksy MA. Identification of risk factors for septic peritonitis and failure to survive following gastrointestinal surgery in dogs. J Am Vet Med Assoc. 2011;238(4):486-494."},{"issue":"2","key":"ref20","series-title":"J Vet Intern Med","first-page":"58","article-title":"A retrospective case-control of acute renal failure in 99 dogs","volume":"11","author":"Vaden SL","year":"1997","unstructured":"Vaden SL, Levine J, Breitschwerdt EB. A retrospective case-control of acute renal failure in 99 dogs. J Vet Intern Med. 1997;11(2):58-64."},{"issue":"1","key":"ref21","series-title":"PLoS One","first-page":"e0190772","article-title":"Acute kidney injury in cats and dogs: a proportional meta-analysis of case series studies","volume":"13","author":"Legatti SAM","year":"2018","unstructured":"Legatti SAM, El Dib R, Legatti E,  Acute kidney injury in cats and dogs: a proportional meta-analysis of case series studies. PLoS One. 2018;13(1):e0190772."},{"issue":"5","key":"ref22","series-title":"Vet Surg","first-page":"393","article-title":"Evaluation of the sensitivity and specificity of diagnostic criteria for sepsis in dogs","volume":"26","author":"Hauptman JG","year":"1997","unstructured":"Hauptman JG, Walshaw R, Olivier NB. Evaluation of the sensitivity and specificity of diagnostic criteria for sepsis in dogs. Vet Surg. 1997;26(5):393-397."},{"issue":"5","key":"ref23","series-title":"J Vet Intern Med","first-page":"1034","article-title":"The acute patient physiologic and laboratory evaluation (APPLE) score: a severity of illness stratification system for hospitalized dogs","volume":"24","author":"Hayes G","year":"2010","unstructured":"Hayes G, Mathews K, Doig G,  The acute patient physiologic and laboratory evaluation (APPLE) score: a severity of illness stratification system for hospitalized dogs. J Vet Intern Med. 2010;24(5):1034-1047."},{"issue":"5","key":"ref24","series-title":"Vet Anaesth Analg","first-page":"581","article-title":"Anaesthetic management and complications of transvascular patent ductus arteriosus occlusion in dogs","volume":"47","author":"Parisi C","year":"2020","unstructured":"Parisi C, Phillips V, Ferreira J, Linney C, Mair A. Anaesthetic management and complications of transvascular patent ductus arteriosus occlusion in dogs. Vet Anaesth Analg. 2020;47(5):581-587."},{"issue":"4","key":"ref25","series-title":"J Am Vet Med Assoc","first-page":"417","article-title":"Effect of anesthesia-associated hypotension on neurologic outcome in dogs undergoing hemilaminectomy because of acute, severe thoracolumbar intervertebral disk herniation: 56 cases (2007-2013)","volume":"250","author":"Dixon A","year":"2017","unstructured":"Dixon A, Fauber AE. Effect of anesthesia-associated hypotension on neurologic outcome in dogs undergoing hemilaminectomy because of acute, severe thoracolumbar intervertebral disk herniation: 56 cases (2007-2013). J Am Vet Med Assoc. 2017;250(4):417-423."},{"key":"ref26","article-title":"Grading of acute kidney injury International Renal Interest Society","author":"Cowgill L","year":"2016","unstructured":"Cowgill L. Grading of acute kidney injury International Renal Interest Society. 2016. Accessed July 17, 2023. www.iris-kidney.com\/pdf\/4_ldc-revised-grading-of-acute-kidney-injury.pdf"},{"issue":"7","key":"ref27","series-title":"Clin J Am Soc Nephrol","first-page":"1039","article-title":"Low-flow acute kidney injury: the pathophysiology of prerenal azotemia, abdominal compartment syndrome, and obstructive uropathy","volume":"17","author":"Molitoris BA","year":"2022","unstructured":"Molitoris BA. Low-flow acute kidney injury: the pathophysiology of prerenal azotemia, abdominal compartment syndrome, and obstructive uropathy. Clin J Am Soc Nephrol. 2022;17(7):1039-1049."},{"issue":"1","key":"ref28","series-title":"Royal Statistical Society","first-page":"289","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini Y","year":"1995","unstructured":"Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. Royal Statistical Society. 1995;57(1):289-300."},{"issue":"1","key":"ref29","series-title":"BMC Nephrol","first-page":"318","article-title":"Rates, predictors, and mortality of sepsis-associated acute kidney injury: a systematic review and meta-analysis","volume":"21","author":"Liu J","year":"2020","unstructured":"Liu J, Xie H, Ye Z, Li F, Wang L. Rates, predictors, and mortality of sepsis-associated acute kidney injury: a systematic review and meta-analysis. BMC Nephrol. 2020;21(1):318."},{"issue":"10","key":"ref30","series-title":"Support Care Cancer","first-page":"1527","article-title":"Small increases in serum creatinine are associated with prolonged ICU stay and increased hospital mortality in critically ill patients with cancer","volume":"19","author":"Samuels J","year":"2011","unstructured":"Samuels J, Ng CS, Nates J,  Small increases in serum creatinine are associated with prolonged ICU stay and increased hospital mortality in critically ill patients with cancer. Support Care Cancer. 2011;19(10):1527-1532."},{"issue":"11","key":"ref31","series-title":"J Am Soc Nephrol","first-page":"3365","article-title":"Acute kidney injury, mortality, length of stay, and costs in hospitalized patients","volume":"16","author":"Chertow GM","year":"2005","unstructured":"Chertow GM, Burdick E, Honour M, Bonventre JV, Bates DW. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol. 2005;16(11):3365-3370."},{"issue":"2","key":"ref32","series-title":"Compr Physiol","first-page":"1303","article-title":"Pathophysiology of acute kidney injury","volume":"2","author":"Basile DP","year":"2012","unstructured":"Basile DP, Anderson MD, Sutton TA. Pathophysiology of acute kidney injury. Compr Physiol. 2012;2(2):1303-1353."},{"key":"ref33","series-title":"Comput Cardiol (2010)","first-page":"1095","article-title":"Hypotension as a risk factor for acute kidney injury in ICU patients","volume":"37","author":"Lehman LW","year":"2010","unstructured":"Lehman LW, Saeed M, Moody G, Mark R. Hypotension as a risk factor for acute kidney injury in ICU patients. Comput Cardiol (2010). 2010;37:1095-1098."},{"key":"ref34","series-title":"StatPearls [Internet]","article-title":"Acute kidney injury","author":"Goyal A","year":"2023","unstructured":"Goyal A, Daneshpajouhnejad P, Hashmi MF, Bashir K. Acute kidney injury. In: StatPearls [Internet]. StatPearls Publishing; 2023."},{"issue":"2","key":"ref35","series-title":"Crit Care Med","first-page":"328","article-title":"Obesity, acute kidney injury, and mortality in critical illness","volume":"44","author":"Danziger J","year":"2016","unstructured":"Danziger J, Chen KP, Lee J,  Obesity, acute kidney injury, and mortality in critical illness. Crit Care Med. 2016;44(2):328-334."},{"key":"ref36","series-title":"Front Endocrinol (Lausanne)","first-page":"534294","article-title":"The association between obesity and risk of acute kidney injury after cardiac surgery","volume":"11","author":"Shi N","year":"2020","unstructured":"Shi N, Liu K, Fan Y,  The association between obesity and risk of acute kidney injury after cardiac surgery. Front Endocrinol (Lausanne). 2020;11:534294."},{"issue":"4","key":"ref37","series-title":"Indian J Crit Care Med","first-page":"231","article-title":"Predictors of mortality in acute kidney injury patients admitted to medicine intensive care unit in a rural tertiary care hospital","volume":"22","author":"Saxena A","year":"2018","unstructured":"Saxena A, Meshram SV. Predictors of mortality in acute kidney injury patients admitted to medicine intensive care unit in a rural tertiary care hospital. Indian J Crit Care Med. 2018;22(4):231-237."},{"issue":"3","key":"ref38","series-title":"Crit Care","first-page":"R73","article-title":"RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis","volume":"10","author":"Hoste EA","year":"2006","unstructured":"Hoste EA, Clermont G, Kersten A,  RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. Crit Care. 2006;10(3):R73."},{"issue":"5","key":"ref39","series-title":"J Vet Intern Med","first-page":"1093","article-title":"Acute azotemia as a predictor of mortality in dogs and cats","volume":"26","author":"Harison E","year":"2012","unstructured":"Harison E, Langston C, Palma D, Lamb K. Acute azotemia as a predictor of mortality in dogs and cats. J Vet Intern Med. 2012;26(5):1093-1098."},{"issue":"1","key":"ref40","series-title":"J Am Soc Nephrol","first-page":"223","article-title":"Acute kidney injury increases risk of ESRD among elderly","volume":"20","author":"Ishani A","year":"2009","unstructured":"Ishani A, Xue JL, Himmelfarb J,  Acute kidney injury increases risk of ESRD among elderly. J Am Soc Nephrol. 2009;20(1):223-228."},{"issue":"12","key":"ref41","series-title":"Kidney Int","first-page":"1361","article-title":"The severity of acute kidney injury predicts progression to chronic kidney disease","volume":"79","author":"Chawla LS","year":"2011","unstructured":"Chawla LS, Amdur RL, Amodeo S, Kimmel PL, Palant CE. The severity of acute kidney injury predicts progression to chronic kidney disease. 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