{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T06:13:06Z","timestamp":1785046386285,"version":"3.55.0"},"reference-count":25,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To evaluate intraoperative and postoperative complications and outcomes following subconjunctival enucleations with and without third eyelid removal in domestic rabbits.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>18 client-owned rabbits with ocular disease confined to the globe that underwent 20 subconjunctival enucleation procedures at a veterinary teaching hospital.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Records were retrospectively reviewed for all enucleations performed at a veterinary teaching hospital from 2014 to 2022. A standard subconjunctival enucleation procedure was performed in all cases, with third eyelid removal in 2 surgeries and without third eyelid removal in the remaining 18 surgeries. Outcomes were assessed on the basis of observations in medical records and owner follow-up.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>20 total enucleations were included. Reported reasons for enucleation included suspected or confirmed ocular <jats:italic>Encephalitozoon cuniculi<\/jats:italic> infection in 9 rabbits, refractory glaucoma in 4 rabbits, and various intraocular diseases in 5 rabbits. The only intraoperative complication reported was hemorrhage during the third eyelid removal in 1 surgery. Postoperative complications included serous to mucoid discharge from the surgical site in 8 of 20 surgeries and swelling at the surgery site in 2 of the 8 cases that had discharge. Postoperative swelling spontaneously resolved within 3 months of surgery; postoperative discharge spontaneously resolved within 10 months of surgery.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Subconjunctival enucleation with or without third eyelid removal in rabbits may be a viable enucleation technique to reduce the risk for intraoperative hemorrhage, but it can result in postoperative complications, including transient discharge and swelling at the surgical site.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.23.04.0207","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T17:56:16Z","timestamp":1688579776000},"page":"1368-1373","source":"Crossref","is-referenced-by-count":5,"title":["Subconjunctival enucleation with or without third eyelid removal may present a viable enucleation technique in rabbits: 18 cases (2014\u20132022)"],"prefix":"10.2460","volume":"261","author":[{"given":"Kara","family":"Hiebert","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Mans","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth","family":"Eaton","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Ferrets, Rabbits, and Rodents","first-page":"446","article-title":"Soft tissue surgery: rabbits","author":"Sanchez-Migallon Guzman D","year":"2020","unstructured":"Sanchez-Migallon Guzman D, Szabo Z, Steffey MA. Soft tissue surgery: rabbits. In: Quesenberry KE, Orcutt CJ, Mans C, Carpenter JW, eds. Ferrets, Rabbits, and Rodents. 4th ed. Elsevier; 2020:446-466. doi:10.1016\/B978-0-323-48435-0.00032-0"},{"key":"ref2","series-title":"BSAVA Manual of Rabbit Surgery, Dentistry and Imaging","first-page":"233","article-title":"Eye and eyelid surgery","author":"Fehr M","year":"2013","unstructured":"Fehr M. Eye and eyelid surgery. In: Harcourt-Brown F, Chitty J, eds. BSAVA Manual of Rabbit Surgery, Dentistry and Imaging. British Small Animal Veterinary Association; 2013:233-253. doi:10.22233\/9781910443163.17"},{"issue":"2","key":"ref3","series-title":"Ir Vet J","first-page":"108","article-title":"Enucleation in companion animals","volume":"61","author":"Mitchell N","year":"2008","unstructured":"Mitchell N. Enucleation in companion animals. Ir Vet J. 2008;61(2):108-114."},{"issue":"1","key":"ref4","series-title":"Vet Clin North Am Exot Anim Pract","first-page":"245","article-title":"Eye removal surgeries in exotic pets","volume":"19","author":"Diehl KA","year":"2016","unstructured":"Diehl KA, McKinnon JA. Eye removal surgeries in exotic pets. Vet Clin North Am Exot Anim Pract. 2016;19(1):245-267. doi:10.1016\/j.cvex.2015.08.003"},{"issue":"2","key":"ref5","series-title":"J Exot Pet Med","first-page":"88","article-title":"Enucleation of exotic pets","volume":"16","author":"Holmberg BJ","year":"2007","unstructured":"Holmberg BJ. Enucleation of exotic pets. J Exot Pet Med. 2007;16(2):88-94. doi:10.1053\/j.jepm.2007.03.011"},{"issue":"3","key":"ref6","series-title":"Semin Avian Exot Pet Med","first-page":"138","article-title":"Rabbit and rodent ophthalmology","volume":"6","author":"Kern TJ","year":"1997","unstructured":"Kern TJ. Rabbit and rodent ophthalmology. Semin Avian Exot Pet Med. 1997;6(3):138-145. doi:10.1016\/S1055-937X(97)80021-7"},{"key":"ref7","series-title":"Trans Am Ophthalmol Soc","first-page":"400.2","article-title":"The anatomy and histology of the eye and orbit of the rabbit","volume":"27","author":"Davis FA","year":"1929","unstructured":"Davis FA. The anatomy and histology of the eye and orbit of the rabbit. Trans Am Ophthalmol Soc. 1929;27:400.2-441."},{"key":"ref8","series-title":"WB Saunders","article-title":"Colour Atlas of Anatomy of Small Laboratory Animals","author":"Popesko P","year":"2002","unstructured":"Popesko P, Rajtova V, Horak J. Colour Atlas of Anatomy of Small Laboratory Animals. Vol 1. WB Saunders; 2002."},{"issue":"2","key":"ref9","series-title":"Vet Ophthalmol","first-page":"409","article-title":"A novel surgical technique for enucleation in rabbits to reduce the risk of intra- and post-operative orbital hemorrhage","volume":"23","author":"Moore BA","year":"2020","unstructured":"Moore BA, Robertson J, Tarbert DK, Good KL, Paul-Murphy JR. A novel surgical technique for enucleation in rabbits to reduce the risk of intra- and post-operative orbital hemorrhage. Vet Ophthalmol. 2020;23(2):409-413. doi:10.1111\/vop.12737"},{"key":"ref10","series-title":"J Exot Pet Med","first-page":"154","article-title":"Post-traumatic ocular lymphoma in three rabbits (Oryctolagus cuniculus)","volume":"28","author":"Keller KA","year":"2019","unstructured":"Keller KA, Sanchez-Migallon Guzman D, Reilly C,  Post-traumatic ocular lymphoma in three rabbits (Oryctolagus cuniculus). J Exot Pet Med. 2019;28:154-161. doi:10.1053\/j.jepm.2018.02.041"},{"issue":"2","key":"ref11","series-title":"J Avian Med Surg","first-page":"120","article-title":"A technique for evisceration as an alternative to enucleation in birds of prey: 19 cases","volume":"27","author":"Murray M","year":"2013","unstructured":"Murray M, Pizzirani S, Tseng F. A technique for evisceration as an alternative to enucleation in birds of prey: 19 cases. J Avian Med Surg. 2013;27(2):120-127. doi:10.1647\/2012-007"},{"issue":"8","key":"ref12","series-title":"Curr Eye Res","first-page":"863","article-title":"A new rabbit model of chronic dry eye disease induced by complete surgical dacryoadenectomy","volume":"44","author":"Honkanen R","year":"2019","unstructured":"Honkanen R, Huang W, Huang L, Kaplowitz K, Weissbart S, Rigas B. A new rabbit model of chronic dry eye disease induced by complete surgical dacryoadenectomy. Curr Eye Res. 2019;44(8):863-872. doi:10.1080\/02713683.2019.1594933"},{"key":"ref13","series-title":"Transl Res","first-page":"58","article-title":"Phosphosulindac is efficacious in an improved concanavalin A-based rabbit model of chronic dry eye disease","volume":"198","author":"Honkanen RA","year":"2018","unstructured":"Honkanen RA, Huang L, Xie G, Rigas B. Phosphosulindac is efficacious in an improved concanavalin A-based rabbit model of chronic dry eye disease. Transl Res. 2018;198:58-72. doi:10.1016\/j.trsl.2018.04.002"},{"issue":"2","key":"ref14","series-title":"Int J Appl Res Vet Med","first-page":"107","article-title":"Results of bacterial culture and sensitivity testing from nasolacrimal duct flushes in one hundred and three both healthy and clinically ill pet rabbits (Oryctolagus cuniculus)","volume":"12","author":"Quinton JF","year":"2014","unstructured":"Quinton JF, Hogerwerf A, Grammatico-Guillon L, Medaille C, Agoulon A, Rosenthal K. Results of bacterial culture and sensitivity testing from nasolacrimal duct flushes in one hundred and three both healthy and clinically ill pet rabbits (Oryctolagus cuniculus). Int J Appl Res Vet Med. 2014;12(2):107-119."},{"issue":"7","key":"ref15","series-title":"J Small Anim Pract","first-page":"417","article-title":"Conjunctival bacterial and fungal flora and cutaneous fungal flora in healthy domestic rabbits (Oryctolagus cuniculus)","volume":"60","author":"Bourguet A","year":"2019","unstructured":"Bourguet A, Desprez I, Volait L,  Conjunctival bacterial and fungal flora and cutaneous fungal flora in healthy domestic rabbits (Oryctolagus cuniculus). J Small Anim Pract. 2019;60(7):417-422. doi:10.1111\/jsap.12989"},{"issue":"12","key":"ref16","series-title":"Pathogens","first-page":"1486","article-title":"A review of Encephalitozoon cuniculi in domestic rabbits (Oryctolagus cuniculus) - biology, clinical signs, diagnostic techniques, treatment, and prevention","volume":"11","author":"Dobo\u0219i AA","year":"2022","unstructured":"Dobo\u0219i AA, Bel LV, Pa\u0219tiu AI, Pusta DL. A review of Encephalitozoon cuniculi in domestic rabbits (Oryctolagus cuniculus) - biology, clinical signs, diagnostic techniques, treatment, and prevention. Pathogens. 2022;11(12):1486. doi:10.3390\/pathogens11121486"},{"issue":"4","key":"ref17","series-title":"Vet Ophthalmol","first-page":"399","article-title":"Rabbits with naturally occurring cataracts referred for phacoemulsification and intraocular lens implantation: a preliminary study of 12 cases","volume":"21","author":"Sanchez RF","year":"2018","unstructured":"Sanchez RF, Everson R, Hedley J,  Rabbits with naturally occurring cataracts referred for phacoemulsification and intraocular lens implantation: a preliminary study of 12 cases. Vet Ophthalmol. 2018;21(4):399-412. doi:10.1111\/vop.12525"},{"key":"ref18","series-title":"Ferrets, Rabbits, and Rodents","first-page":"583","article-title":"Ophthalmologic diseases of small mammals","author":"van der Woerdt A","year":"2020","unstructured":"van der Woerdt A. Ophthalmologic diseases of small mammals. In: Quesenberry KE, Orcutt CJ, Mans C, Carpenter JW, eds. Ferrets, Rabbits, and Rodents. 4th ed. Elsevier; 2020:583-594. doi:10.1016\/B978-0-323-48435-0.00040-X"},{"key":"ref19","series-title":"J Exot Pet Med","first-page":"67","article-title":"Diagnosis and treatment of glaucoma in client-owned rabbits (Oryctolagus cuniculus): 16 eyes from 11 rabbits (2008-2019)","volume":"34","author":"Yuschenkoff D","year":"2020","unstructured":"Yuschenkoff D, Graham J, Pumphrey SA. Diagnosis and treatment of glaucoma in client-owned rabbits (Oryctolagus cuniculus): 16 eyes from 11 rabbits (2008-2019). J Exot Pet Med. 2020;34:67-71. doi:10.1053\/j.jepm.2020.03.009"},{"issue":"6","key":"ref20","series-title":"J Am Vet Med Assoc","first-page":"661","article-title":"Subconjunctival enucleation with orbital implant placement in standing horses: 20 cases (2014-2017)","volume":"258","author":"Betbeze CM","year":"2021","unstructured":"Betbeze CM, Dray SM, Fontenot RL. Subconjunctival enucleation with orbital implant placement in standing horses: 20 cases (2014-2017). J Am Vet Med Assoc. 2021;258(6):661-667. doi:10.2460\/javma.258.6.661"},{"issue":"6","key":"ref21","series-title":"Surg Infect (Larchmt)","first-page":"722","article-title":"Prolonged operative duration increases risk of surgical site infections: a systematic review","volume":"18","author":"Cheng H","year":"2017","unstructured":"Cheng H, Chen BPH, Soleas IM, Ferko NC, Cameron CG, Hinoul P. Prolonged operative duration increases risk of surgical site infections: a systematic review. Surg Infect (Larchmt). 2017;18(6):722-735. doi:10.1089\/sur.2017.089"},{"key":"ref22","series-title":"Front Vet Sci","first-page":"760628","article-title":"Incidence and risk factors for surgical site infections following oromaxillofacial oncologic surgery in dogs","volume":"8","author":"Rigby BE","year":"2021","unstructured":"Rigby BE, Malott K, Hetzel SJ, Soukup JW. Incidence and risk factors for surgical site infections following oromaxillofacial oncologic surgery in dogs. Front Vet Sci. 2021;8:760628. doi:10.3389\/fvets.2021.760628"},{"issue":"9","key":"ref23","series-title":"Epidemiol Infect","first-page":"1326","article-title":"Perioperative antibiotic prophylaxis: improved compliance and impact on infection rates","volume":"139","author":"Prospero E","year":"2011","unstructured":"Prospero E, Barbadoro P, Marigliano A, Martini E, D\u2019Errico MM. Perioperative antibiotic prophylaxis: improved compliance and impact on infection rates. Epidemiol Infect. 2011;139(9):1326-1331. doi:10.1017\/S0950268810002505"},{"issue":"1","key":"ref24","series-title":"BMC Vet Res","first-page":"52","article-title":"Prospective clinical study to evaluate an oscillometric blood pressure monitor in pet rabbits","volume":"14","author":"Bellini L","year":"2018","unstructured":"Bellini L, Veladiano IA, Schrank M, Candaten M, Mollo A. Prospective clinical study to evaluate an oscillometric blood pressure monitor in pet rabbits. BMC Vet Res. 2018;14(1):52. doi:10.1186\/s12917-018-1369-4"},{"issue":"S01","key":"ref25","series-title":"Eur Spine J","first-page":"S66","article-title":"Controlled hypotension for spinal surgery","volume":"13 suppl 1","author":"Dutton RP","year":"2004","unstructured":"Dutton RP. Controlled hypotension for spinal surgery. Eur Spine J. 2004;13 suppl 1(S01):S66-S71. doi:10.1007\/s00586-004-0756-7"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/261\/9\/javma.23.04.0207.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/261\/9\/javma.23.04.0207.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/261\/9\/javma.23.04.0207.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T22:00:28Z","timestamp":1727301628000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/261\/9\/javma.23.04.0207.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,1]]},"references-count":25,"journal-issue":{"issue":"9"},"URL":"https:\/\/doi.org\/10.2460\/javma.23.04.0207","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9,1]]}}}