{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T05:24:13Z","timestamp":1741411453255,"version":"3.38.0"},"reference-count":7,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To estimate the incidence of and identify patient risk factors for an acute adverse event in dogs after administration of a sustained-release injectable heartworm preventive product.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>Canine patients that received the injectable heartworm preventive product during routine preventive care visits.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Retrospective analysis of electronic medical records of canine visits within a large network of primary care veterinary clinics in which the product was administered from January 1, 2016, through December 31, 2020. Visits during which vaccination(s) were also administered were excluded from analysis. Identification of acute adverse events was based on diagnostic entries and other clinical presentations suggestive of an adverse event within 3 days of product administration. Data were analyzed using mixed-effects logistic regression.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>In the 5-year study period, 1,399,289 visits with 694,030 dogs led to an incidence estimate of approximately 14.3 events\/10,000 doses. Regression analysis found younger dogs and 7 breeds (relative to mixed-breed dogs) to have statistically significant greater odds of an event.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Understanding of incidence and patient risk factors provides veterinary professionals and dog owners more information when deciding on heartworm preventive options for their dog when considering risk for adverse event in dogs of certain ages or breeds.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.23.04.0217","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T17:09:15Z","timestamp":1687972155000},"page":"1666-1672","source":"Crossref","is-referenced-by-count":0,"title":["Younger dogs of specific breeds are more likely to experience a rare adverse event after administration of extended-release injectable moxidectin heartworm preventive"],"prefix":"10.2460","volume":"261","author":[{"given":"Emi K.","family":"Saito","sequence":"first","affiliation":[{"name":"Banfield Pet Hospital, Vancouver, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George E.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JoAnn","family":"Morrison","sequence":"additional","affiliation":[{"name":"Banfield Pet Hospital, Vancouver, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathaniel","family":"Spofford","sequence":"additional","affiliation":[{"name":"Banfield Pet Hospital, Vancouver, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Yang","sequence":"additional","affiliation":[{"name":"Banfield Pet Hospital, Vancouver, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Adv Parasitol","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0065-308X(08)00204-2","article-title":"Heartworm disease in animals and humans","volume":"66","author":"McCall JW","year":"2008","unstructured":"McCall JW, Genchi C, Kramer LH, Guerrero J, Venco L. Heartworm disease in animals and humans. Adv Parasitol. 2008;66:193-285. doi:10.1016\/S0065-308X(08)00204-2"},{"article-title":"ProHeart 6 (moxidectin) sustained release injectable for dogs","series-title":"US Food and Drug Administration Center for Veterinary Medicine","key":"ref2","unstructured":"Freedom of Information Summary for New Animal Drug Application NADA 141-189: ProHeart 6 (moxidectin) sustained release injectable for dogs . US Food and Drug Administration Center for Veterinary Medicine. June 6, 2001. Accessed May 2022. https:\/\/animaldrugsatfda.fda.gov\/adafda\/app\/search\/public\/document\/downloadFoi\/700"},{"article-title":"ProHeart 12 (moxidectin) for dogs.","series-title":"US Food and Drug Administration Center for Veterinary Medicine","key":"ref3","unstructured":"Freedom of Information Summary for New Animal Drug Application NADA 141-519: ProHeart 12 (moxidectin) for dogs. US Food and Drug Administration Center for Veterinary Medicine. July 2, 2019. Accessed May 2022. https:\/\/animaldrugsatfda.fda.gov\/adafda\/app\/search\/public\/document\/downloadFoi\/7307"},{"article-title":"Zoetis United States","author":"ProHeart certification","key":"ref4","unstructured":"ProHeart certification. Zoetis United States. Accessed September 2022. https:\/\/www2.zoetisus.com\/products\/petcare\/proheartcertification\/proheart-certification"},{"issue":"1","key":"ref5","series-title":"Vet Rec Open","first-page":"e000224","article-title":"Veterinary pharmacovigilance in Europe: a survey of veterinary practitioners","volume":"4","author":"De Briyne N","year":"2017","unstructured":"De Briyne N, Gopal R, Diesel G, Iatridou D, O\u2019Rourke D. Veterinary pharmacovigilance in Europe: a survey of veterinary practitioners. Vet Rec Open. 2017;4(1):e000224. doi:10.1136\/vetreco-2017-000224"},{"issue":"2","key":"ref6","series-title":"Int J Appl Res Vet Med","first-page":"49","article-title":"Safety profile of moxidectin (ProHeart 6) and two oral heartworm preventives in dogs","volume":"3","author":"Glickman LT","year":"2005","unstructured":"Glickman LT, Glickman NW, Moore GE,  Safety profile of moxidectin (ProHeart 6) and two oral heartworm preventives in dogs. Int J Appl Res Vet Med. 2005;3(2):49-61."},{"issue":"7","key":"ref7","series-title":"J Am Vet Med Assoc","first-page":"1102","article-title":"Adverse events diagnosed within three days of vaccine administration in dogs","volume":"227","author":"Moore GE","year":"2005","unstructured":"Moore GE, Guptill LF, Ward MP,  Adverse events diagnosed within three days of vaccine administration in dogs. J Am Vet Med Assoc. 2005;227(7):1102-1108. doi:10.2460\/javma.2005.227.1102"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/261\/11\/javma.23.04.0217.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/261\/11\/javma.23.04.0217.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/261\/11\/javma.23.04.0217.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T13:05:22Z","timestamp":1741352722000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/261\/11\/javma.23.04.0217.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,1]]},"references-count":7,"journal-issue":{"issue":"11"},"URL":"https:\/\/doi.org\/10.2460\/javma.23.04.0217","relation":{},"ISSN":["0003-1488"],"issn-type":[{"type":"print","value":"0003-1488"}],"subject":[],"published":{"date-parts":[[2023,11,1]]}}}