{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:47:58Z","timestamp":1793119678153,"version":"4.5.0"},"reference-count":32,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To determine the prevalence of splenic malignancy in cats undergoing splenectomy and to investigate possible factors associated with post-operative outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>ANIMALS<\/jats:title>\n                    <jats:p>62 client-owned cats that underwent splenectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Medical records of 4 UK-based referral hospitals were searched and data reviewed retrospectively over 17 years. Factors associated with outcomes post-splenectomy were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      50 out of 62 cats (81%) were diagnosed with splenic neoplasia. Mast cell tumor ([MCT], 42%), hemangiosarcoma ([HSA], 40%), lymphoma and histiocytic sarcoma (6% each) were the most common tumor types. Fifteen cats (24%) presented with spontaneous hemoabdomen and were all diagnosed with splenic neoplasia. The diagnostic accuracy of cytology to detect splenic malignant lesions was 73% (100% for MCTs and 54% for mesenchymal tumors). Median survival time for cats with nonneoplastic splenic lesions was 715 days (IQR, 18 to 1,368) and 136 days for cats with splenic neoplasia (IQR, 35 to 348); median survival time was longer for cats with splenic MCT when compared to cats with HSA (348 vs 94 days;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001). Presence of metastatic disease and anemia (PCV &lt; 24%) at diagnosis were associated with a poorer survival when considering all cats. Presence of anemia, a splenic mass on imaging or spontaneous hemoabdomen were associated with a diagnosis of HSA (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CLINICAL RELEVANCE<\/jats:title>\n                    <jats:p>Benign splenic lesions were uncommon in this cohort of cats. Spontaneous hemoabdomen should prompt the clinician to suspect neoplasia in cats with splenic disease. Anemia and evidence of metastasis at diagnosis were poor prognostic factors regardless of the final diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/javma.23.05.0258","type":"journal-article","created":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T08:17:45Z","timestamp":1692087465000},"page":"1646-1652","source":"Crossref","is-referenced-by-count":8,"title":["Prevalence of malignancy and factors affecting outcome of cats undergoing splenectomy"],"prefix":"10.2460","volume":"261","author":[{"given":"Matteo","family":"Rossanese","sequence":"first","affiliation":[{"name":"The Royal Veterinary College Department of Clinical Science and Services, Hatfield, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Williams","sequence":"additional","affiliation":[{"name":"Small Animal Teaching Hospital of the University of Liverpool, Neston, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benito de la","family":"Puerta","sequence":"additional","affiliation":[{"name":"North Down Specialist Referrals, Bletchingley, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Scott","sequence":"additional","affiliation":[{"name":"Small Animal Referral Hospital Langford Vets, University of Bristol, Bristol, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Chanoit","sequence":"additional","affiliation":[{"name":"Small Animal Referral Hospital Langford Vets, University of Bristol, Bristol, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Guill\u00e9n","sequence":"additional","affiliation":[{"name":"The Royal Veterinary College Department of Clinical Science and Services, Hatfield, England"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"1","key":"ref1","series-title":"J Small Anim Pract","first-page":"7","article-title":"Observations on the pathology of the spleen of the cat","volume":"9","author":"Ishmael J","year":"1968","unstructured":"Ishmael J, Howell JM. Observations on the pathology of the spleen of the cat. J Small Anim Pract. 1968;9(1):7-13. doi:10.1111\/j.1748-5827.1968.tb04679.x"},{"issue":"5","key":"ref2","series-title":"J Am Vet Med Assoc","first-page":"773","article-title":"Prevalence and type of splenic diseases in cats: 455 cases (1985-1991)","volume":"201","author":"Spangler WL","year":"1992","unstructured":"Spangler WL, Culbertson MR. Prevalence and type of splenic diseases in cats: 455 cases (1985-1991). J Am Vet Med Assoc. 1992;201(5):773-776."},{"issue":"3","key":"ref3","series-title":"J Feline Med Surg","first-page":"177","article-title":"Characterisation of the signalment, clinical and survival characteristics of 41 cats with mast cell neoplasia","volume":"8","author":"Litster AL","year":"2006","unstructured":"Litster AL, Sorenmo KU. Characterisation of the signalment, clinical and survival characteristics of 41 cats with mast cell neoplasia. J Feline Med Surg. 2006;8(3):177-183. doi:10.1016\/j.jfms.2005.12.005"},{"issue":"4","key":"ref4","series-title":"J Feline Med Surg","first-page":"256","article-title":"Outcome following splenectomy in cats","volume":"12","author":"Gordon SS","year":"2010","unstructured":"Gordon SS, McClaran JK, Bergman PJ, Liu SM. Outcome following splenectomy in cats. J Feline Med Surg. 2010;12(4):256-261. doi:10.1016\/j.jfms.2009.09.005"},{"issue":"11","key":"ref5","series-title":"J Am Vet Med Assoc","first-page":"1267","article-title":"Incidence of malignancy and outcomes for dogs undergoing splenectomy for incidentally detected nonruptured splenic nodules or masses: 105 cases (2009-2013)","volume":"248","author":"Cleveland MJ","year":"2016","unstructured":"Cleveland MJ, Casale S. Incidence of malignancy and outcomes for dogs undergoing splenectomy for incidentally detected nonruptured splenic nodules or masses: 105 cases (2009-2013). J Am Vet Med Assoc. 2016;248(11):1267-1273. doi:10.2460\/javma.248.11.1267"},{"issue":"5","key":"ref6","series-title":"J Am Vet Med Assoc","first-page":"690","article-title":"Correlation of ultrasonographic appearance of lesions and cytologic and histologic diagnoses in splenic aspirates from dogs and cats: 32 cases (2002-2005)","volume":"230","author":"Ballegeer EA","year":"2007","unstructured":"Ballegeer EA, Forrest LJ, Dickinson RM, Schutten MM, Delaney FA, Young KM. Correlation of ultrasonographic appearance of lesions and cytologic and histologic diagnoses in splenic aspirates from dogs and cats: 32 cases (2002-2005). J Am Vet Med Assoc. 2007;230(5):690-696. doi:10.2460\/javma.230.5.690"},{"issue":"1","key":"ref7","series-title":"J Feline Med Surg","first-page":"23","article-title":"Association between ultrasonographic appearance of splenic parenchyma and cytology in cats","volume":"20","author":"Bertal M","year":"2018","unstructured":"Bertal M, Norman Carmel E, Diana A, Desquilbet L, Specchi S, Pey P. Association between ultrasonographic appearance of splenic parenchyma and cytology in cats. J Feline Med Surg. 2018;20(1):23-29. doi:10.1177\/1098612X17697483"},{"issue":"3","key":"ref8","series-title":"J Vet Intern Med","first-page":"102","article-title":"Fine-needle aspiration of the spleen as an aid in the diagnosis of splenomegaly","volume":"1","author":"O\u2019Keefe DA","year":"1987","unstructured":"O\u2019Keefe DA, Couto CG. Fine-needle aspiration of the spleen as an aid in the diagnosis of splenomegaly. J Vet Intern Med. 1987;1(3):102-109. doi:10.1111\/j.1939-1676.1987.tb01997.x"},{"issue":"3","key":"ref9","series-title":"Vet Radiol","first-page":"117","article-title":"Ultrasonographic findings in hepatic and splenic lymphosarcoma in dogs and cats","volume":"32","author":"Lamb CR","year":"1991","unstructured":"Lamb CR, Hartzband LE, Tidwell AS, Pearson SH. Ultrasonographic findings in hepatic and splenic lymphosarcoma in dogs and cats. Vet Radiol. 1991;32(3):117-120. doi:10.1111\/j.1740-8261.1991.tb00093.x"},{"issue":"5","key":"ref10","series-title":"Vet Radiol Ultrasound","first-page":"441","article-title":"Ultrasonographic appearance of splenic disease in 101 cats","volume":"42","author":"Hanson JA","year":"2001","unstructured":"Hanson JA, Papageorges M, Girard E, Menard M, Hebert P. Ultrasonographic appearance of splenic disease in 101 cats. Vet Radiol Ultrasound. 2001;42(5):441-445. doi:10.1111\/j.1740-8261.2001.tb00967.x"},{"issue":"4","key":"ref11","series-title":"J Am Vet Med Assoc","first-page":"553","article-title":"Prevalence of hemangiosarcoma in anemic dogs with a splenic mass and hemoperitoneum requiring a transfusion: 71 cases (2003-2005)","volume":"232","author":"Hammond TN","year":"2008","unstructured":"Hammond TN, Pesillo-Crosby SA. Prevalence of hemangiosarcoma in anemic dogs with a splenic mass and hemoperitoneum requiring a transfusion: 71 cases (2003-2005). J Am Vet Med Assoc. 2008;232(4):553-558. doi:10.2460\/javma.232.4.553"},{"issue":"2","key":"ref12","series-title":"J Am Anim Hosp Assoc","first-page":"72","article-title":"Prognosis for acute nontraumatic hemoperitoneum in the dog: a retrospective analysis of 60 cases (2003-2006)","volume":"45","author":"Aronsohn MG","year":"2009","unstructured":"Aronsohn MG, Dubiel B, Roberts B, Powers BE. Prognosis for acute nontraumatic hemoperitoneum in the dog: a retrospective analysis of 60 cases (2003-2006). J Am Anim Hosp Assoc. 2009;45(2):72-77. doi:10.5326\/0450072"},{"issue":"9","key":"ref13","series-title":"J Am Vet Med Assoc","first-page":"978","article-title":"Spontaneous hemoperitoneum in cats: 65 cases (1994-2006)","volume":"236","author":"Culp WT","year":"2010","unstructured":"Culp WT, Weisse C, Kellogg ME,  Spontaneous hemoperitoneum in cats: 65 cases (1994-2006). J Am Vet Med Assoc. 2010;236(9):978-982. doi:10.2460\/javma.236.9.978"},{"issue":"6","key":"ref14","series-title":"J Vet Med Sci","first-page":"817","article-title":"Disseminated histiocytic sarcoma with excessive hemophagocytosis in a cat","volume":"71","author":"Ide K","year":"2009","unstructured":"Ide K, Setoguchi-Mukai A, Nakagawa T,  Disseminated histiocytic sarcoma with excessive hemophagocytosis in a cat. J Vet Med Sci. 2009;71(6):817-820. doi:10.1292\/jvms.71.817"},{"issue":"8","key":"ref15","series-title":"J Am Vet Med Assoc","first-page":"1101","article-title":"Myelolipoma of the spleen in a cat","volume":"160","author":"Sander CH","year":"1972","unstructured":"Sander CH, Langham RF. Myelolipoma of the spleen in a cat. J Am Vet Med Assoc. 1972;160(8):1101-1103."},{"issue":"4","key":"ref16","series-title":"J Am Anim Hosp Assoc","first-page":"239","article-title":"Clinical signs, treatment, and outcome in cats with myeloma-related disorder receiving systemic therapy","volume":"51","author":"Cannon CM","year":"2015","unstructured":"Cannon CM, Knudson C, Borgatti A. Clinical signs, treatment, and outcome in cats with myeloma-related disorder receiving systemic therapy. J Am Anim Hosp Assoc. 2015;51(4):239-248. doi:10.5326\/JAAHA-MS-6216"},{"issue":"12","key":"ref17","series-title":"J Am Vet Med Assoc","first-page":"1382","article-title":"Risk factors for perioperative death in dogs undergoing splenectomy for splenic masses: 539 cases (2001-2012)","volume":"245","author":"Wendelburg KM","year":"2014","unstructured":"Wendelburg KM, O\u2019Toole TE, McCobb E, Price LL, Lyons JA, Berg J. Risk factors for perioperative death in dogs undergoing splenectomy for splenic masses: 539 cases (2001-2012). J Am Vet Med Assoc. 2014;245(12):1382-1390. doi:10.2460\/javma.245.12.1382"},{"issue":"4","key":"ref18","series-title":"J Am Anim Hosp Assoc","first-page":"220","article-title":"Occurrence and clinicopathologic features of splenic neoplasia based on body weight: 325 dogs (2003-2013)","volume":"52","author":"Sherwood JM","year":"2016","unstructured":"Sherwood JM, Haynes AM, Klocke E,  Occurrence and clinicopathologic features of splenic neoplasia based on body weight: 325 dogs (2003-2013). J Am Anim Hosp Assoc. 2016;52(4):220-226. doi:10.5326\/JAAHA-MS-6346"},{"issue":"10","key":"ref19","series-title":"J Am Vet Med Assoc","first-page":"1325","article-title":"Mass-to-splenic volume ratio and splenic weight as a percentage of body weight in dogs with malignant and benign splenic masses: 65 cases (2007-2008)","volume":"239","author":"Mallinckrodt MJ","year":"2011","unstructured":"Mallinckrodt MJ, Gottfried SD. Mass-to-splenic volume ratio and splenic weight as a percentage of body weight in dogs with malignant and benign splenic masses: 65 cases (2007-2008). J Am Vet Med Assoc. 2011;239(10):1325-1327. doi:10.2460\/javma.239.10.1325"},{"issue":"4","key":"ref20","series-title":"J Am Anim Hosp Assoc","first-page":"231","article-title":"Outcome and prognostic indicators in cats undergoing splenectomy for splenic mast cell tumors","volume":"51","author":"Kraus KA","year":"2015","unstructured":"Kraus KA, Clifford CA, Davis GJ, Kiefer KM, Drobatz KJ. Outcome and prognostic indicators in cats undergoing splenectomy for splenic mast cell tumors. J Am Anim Hosp Assoc. 2015;51(4):231-238. doi:10.5326\/JAAHA-MS-6280"},{"key":"ref21","series-title":"Proc Ann Conf Vet Cancer Soc","first-page":"50","article-title":"Splenic mast cell tumours in 43 cats (1975-1992)","volume":"12","author":"Feinmehl R","year":"1992","unstructured":"Feinmehl R, Matus R, Mauldin GN,  Splenic mast cell tumours in 43 cats (1975-1992). Proc Ann Conf Vet Cancer Soc. 1992;12:50."},{"issue":"1","key":"ref22","series-title":"Vet Comp Oncol","first-page":"20","article-title":"Treatment outcomes and prognostic factors of feline splenic mast cell tumors: a multi-institutional retrospective study of 64 cases","volume":"16","author":"Evans BJ","year":"2018","unstructured":"Evans BJ, O\u2019Brien D, Allstadt SD, Gregor TP, Sorenmo KU. Treatment outcomes and prognostic factors of feline splenic mast cell tumors: a multi-institutional retrospective study of 64 cases. Vet Comp Oncol. 2018;16(1):20-27. doi:10.1111\/vco.12305"},{"issue":"2","key":"ref23","series-title":"J Feline Med Surg","first-page":"81","article-title":"A retrospective study of 180 anaemic cats: features, aetiologies and survival data","volume":"15","author":"Korman RM","year":"2013","unstructured":"Korman RM, Hetzel N, Knowles TG, Harvey AM, Tasker S. A retrospective study of 180 anaemic cats: features, aetiologies and survival data. J Feline Med Surg. 2013;15(2):81-90. doi:10.1177\/1098612X12461008"},{"issue":"1","key":"ref24","series-title":"Vet Surg","first-page":"61","article-title":"A systematic review of criteria used to report complications in soft tissue and oncologic surgical clinical research studies in dogs and cats","volume":"49","author":"Follette CM","year":"2020","unstructured":"Follette CM, Giuffrida MA, Balsa IM,  A systematic review of criteria used to report complications in soft tissue and oncologic surgical clinical research studies in dogs and cats. Vet Surg. 2020;49(1):61-69. doi:10.1111\/vsu.13279"},{"issue":"2","key":"ref25","series-title":"Ann Surg","first-page":"177","article-title":"The accordion severity grading system of surgical complications","volume":"250","author":"Strasberg SM","year":"2009","unstructured":"Strasberg SM, Linehan DC, Hawkins WG. The accordion severity grading system of surgical complications. Ann Surg. 2009;250(2):177-186. doi:10.1097\/SLA.0b013e3181afde41"},{"issue":"11","key":"ref26","series-title":"PLoS One","first-page":"e0224945","article-title":"Evaluation of cytological diagnostic accuracy for canine splenic neoplasms: an investigation in 78 cases using STARD guidelines","volume":"14","author":"Tecilla M","year":"2019","unstructured":"Tecilla M, Gambini M, Forlani A, Caniatti M, Ghisleni G, Roccabianca P. Evaluation of cytological diagnostic accuracy for canine splenic neoplasms: an investigation in 78 cases using STARD guidelines. PLoS One. 2019;14(11):e0224945. doi:10.1371\/journal.pone.0224945"},{"issue":"4","key":"ref27","series-title":"Vet Radiol Ultrasound","first-page":"289","article-title":"Comparison between malignant and nonmalignant splenic masses in dogs using contrast-enhanced computed tomography","volume":"45","author":"Fife WD","year":"2004","unstructured":"Fife WD, Samii VF, Drost WT, Mattoon JS, Hoshaw-Woodard S. Comparison between malignant and nonmalignant splenic masses in dogs using contrast-enhanced computed tomography. Vet Radiol Ultrasound. 2004;45(4):289-297. doi:10.1111\/j.1740-8261.2004.04054.x"},{"issue":"2","key":"ref28","series-title":"Vet Radiol Ultrasound","first-page":"154","article-title":"Use of contrast-enhanced ultrasound for characterization of focal splenic lesions","volume":"49","author":"Rossi F","year":"2008","unstructured":"Rossi F, Leone VF, Vignoli M, Laddaga E, Terragni R. Use of contrast-enhanced ultrasound for characterization of focal splenic lesions. Vet Radiol Ultrasound. 2008;49(2):154-164. doi:10.1111\/j.1740-8261.2008.00343.x"},{"key":"ref29","series-title":"J Am Anim Hosp Assoc","first-page":"589","article-title":"Feline systemic mastocytosis: a review and results of splenectomy in 7 cases","volume":"15","author":"Liska WD","year":"1979","unstructured":"Liska WD, MacEwen EG, Farouk AZ, Garvey M. Feline systemic mastocytosis: a review and results of splenectomy in 7 cases. J Am Anim Hosp Assoc. 1979;15:589-597."},{"issue":"8","key":"ref30","series-title":"J Am Vet Med Assoc","first-page":"817","article-title":"Hemangiosarcoma in the cat: retrospective evaluation of 31 surgical cases","volume":"187","author":"Scavelli TD","year":"1985","unstructured":"Scavelli TD, Patnaik AK, Mehlhaff CJ, Hayes AA. Hemangiosarcoma in the cat: retrospective evaluation of 31 surgical cases. J Am Vet Med Assoc. 1985;187(8):817-819."},{"issue":"12","key":"ref31","series-title":"J Feline Med Surg","first-page":"960","article-title":"Mastocytaemia in cats: prevalence, detection and quantification methods, haematological associations and potential implications in 30 cats with mast cell tumours","volume":"12","author":"Skeldon NC","year":"2010","unstructured":"Skeldon NC, Gerber KL, Wilson RJ, Cunnington SJ. Mastocytaemia in cats: prevalence, detection and quantification methods, haematological associations and potential implications in 30 cats with mast cell tumours. J Feline Med Surg. 2010;12(12):960-966. doi:10.1016\/j.jfms.2010.08.003"},{"issue":"3","key":"ref32","series-title":"Vet Comp Oncol","first-page":"1051","article-title":"Kit receptor tyrosine kinase dysregulations in feline splenic mast cell tumours","volume":"15","author":"Sabattini S","year":"2017","unstructured":"Sabattini S, Barzon G, Giantin M,  Kit receptor tyrosine kinase dysregulations in feline splenic mast cell tumours. 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