{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T16:08:51Z","timestamp":1785600531791,"version":"3.56.0"},"reference-count":23,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Infection by <jats:italic>Histoplasma<\/jats:italic> organisms most commonly results in disseminated systemic infection in cats. Relapse during therapy with itraconazole and fluconazole has been reported. The aim of this study was to report the clinical response, duration of therapy, side effects, and outcome in cats with histoplasmosis that were treated with voriconazole.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>6 client-owned cats.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL PRESENTATION<\/jats:title>\n<jats:p>Medical records were reviewed of cats with confirmed histoplasmosis that presented to the Kansas State University Veterinary Health Center and received voriconazole therapy (n = 6 cats).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>4 cats were switched to voriconazole from fluconazole (n = 2), itraconazole (1), or both (1), and 2 cats received voriconazole as initial therapy. Median starting dosage was 3.51 mg\/kg PO every 72 hours. Two cats required a change in dosing interval from every 72 hours to every 96 hours due to hyporexia (n = 2) and an elevated ALT (1). Remission was documented in all 6 cats with a median time to a negative urine antigen of 256 days (range, 94 to 494 days).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Voriconazole therapy in 6 cats with histoplasmosis yielded mild side effects and a favorable outcome. Reported dosages provide a feasible alternative to daily dosing for owners of feline patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.23.05.0276","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T14:08:15Z","timestamp":1690812495000},"page":"1-5","source":"Crossref","is-referenced-by-count":2,"title":["Oral voriconazole therapy in cats with histoplasmosis yielded mild side effects and a favorable outcome"],"prefix":"10.2460","volume":"261","author":[{"given":"Loren F.","family":"Easterwood","sequence":"first","affiliation":[{"name":"BluePearl Veterinary Hospital for Pets, Overland Park, KS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth R.","family":"Harkin","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy J.","family":"Rankin","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"6","key":"ref1","series-title":"PLoS Negl Trop Dis","first-page":"e0004732","article-title":"Worldwide phylogenetic distributions and population dynamics of the genus Histoplasma","volume":"10","author":"Teixeira MM","year":"2016","unstructured":"Teixeira MM, Patan\u00e9 JS, Taylor ML,  Worldwide phylogenetic distributions and population dynamics of the genus Histoplasma. PLoS Negl Trop Dis. 2016;10(6):e0004732. doi:10.1371\/journal.pntd.0004732"},{"key":"ref2","article-title":"Histoplasmosis maps. CDC","unstructured":"Histoplasmosis maps. CDC. January 14, 2021. Accessed February 16, 2023. https:\/\/www.cdc.gov\/fungal\/diseases\/histoplasmosis\/maps.html"},{"issue":"6","key":"ref3","series-title":"Emerg Infect Dis","first-page":"1071","article-title":"Histoplasmosis in Idaho and Montana, USA, 2012-2013","volume":"21","author":"Nett RJ","year":"2015","unstructured":"Nett RJ, Skillman D, Riek L,  Histoplasmosis in Idaho and Montana, USA, 2012-2013. Emerg Infect Dis. 2015;21(6):1071-1072. doi:10.3201\/eid2106.141367"},{"issue":"12","key":"ref4","series-title":"J Feline Med Surg","first-page":"841","article-title":"Feline histoplasmosis: fluconazole therapy and identification of potential sources of Histoplasma species exposure","volume":"14","author":"Reinhart JM","year":"2012","unstructured":"Reinhart JM, KuKanich KS, Jackson T, Harkin KR. Feline histoplasmosis: fluconazole therapy and identification of potential sources of Histoplasma species exposure. J Feline Med Surg. 2012;14(12):841-848. doi:10.1177\/1098612X12452494"},{"issue":"11","key":"ref5","series-title":"J Am Vet Med Assoc","first-page":"1330","article-title":"Prevalence of ocular lesions in cats newly diagnosed with histoplasmosis: 55 cases (2015-2022)","volume":"260","author":"Pucket JD","year":"2022","unstructured":"Pucket JD, Fentiman KE, McCool ES, Hanzlicek AS. Prevalence of ocular lesions in cats newly diagnosed with histoplasmosis: 55 cases (2015-2022). J Am Vet Med Assoc. 2022;260(11):1330-1333. doi:10.2460\/javma.22.03.0142"},{"issue":"8","key":"ref6","series-title":"J Feline Med Surg","first-page":"512","article-title":"Clinical evaluation of urine Histoplasma capsulatum antigen measurement in cats with suspected disseminated histoplasmosis","volume":"14","author":"Cook AK","year":"2012","unstructured":"Cook AK, Cunningham LY, Cowell AK, Wheat LJ. 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