{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:45:18Z","timestamp":1789685118856,"version":"4.0.1"},"reference-count":27,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To describe radiotherapy outcomes for canine infiltrative lipomas and provide detailed radiotherapy planning data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>ANIMALS<\/jats:title>\n                    <jats:p>24 dogs from 2000 to 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In this retrospective study, dogs received 1 to 3 surgeries prior to conventionally fractionated radiotherapy for gross (18) or microscopic (8) infiltrative lipomas. Dogs received 45 to 51 Gray (Gy) in 15 to 20 daily fractions, with 71% of dogs receiving 48 Gy in daily 3-Gy fractions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Masses were regionally located as follows: limbs (7), trunk (13), head\/neck (4). At analysis, 16\/24 dogs were deceased, 5\/24 were alive (median follow-up for alive dogs: 1,216 days [range, 741 to 1,870 days]), and 3\/24 were lost to follow-up. One living dog had progressive disease 923 days after completing conventionally fractionated radiotherapy and received another surgery. The estimated median overall survival (OS) after completing radiotherapy was 4.8 years (1,760 days; 95% CI, 1,215 to 2,777 days; range, 23 to 3,499 days) for any cause of death, and no patients were reported to have been euthanized or died from their tumor. No statistically significant difference was found for dogs based on gross versus microscopic disease (gross OS, 4.8 years vs microscopic OS, 3.6 years;\n                      <jats:italic>P<\/jats:italic>\n                      = .45). Furthermore, the number of surgeries before radiotherapy did not impact survival (\n                      <jats:italic>P<\/jats:italic>\n                      = .96). The survival difference between females (median OS, 7.6 years; 95% CI, 963 days to not reached) versus males (median OS, 4.6 years; 95% CI, 335 to 2,245 days;\n                      <jats:italic>P<\/jats:italic>\n                      = .05) was statistically significant, although 4\/5 living dogs were female.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CLINICAL RELEVANCE<\/jats:title>\n                    <jats:p>This study demonstrates lengthy survivals with radiotherapy, even with gross disease, for dogs with infiltrative lipomas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/javma.23.05.0288","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T10:07:35Z","timestamp":1690798055000},"page":"1-8","source":"Crossref","is-referenced-by-count":9,"title":["Conventionally fractionated radiation therapy is associated with long-term survival in dogs with infiltrative lipomas"],"prefix":"10.2460","volume":"261","author":[{"given":"Yuchen","family":"Feng","sequence":"first","affiliation":[{"name":"William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Kent","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain P.","family":"Th\u00e9on","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine S.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"3","key":"ref1","series-title":"Vet Pathol","first-page":"316","article-title":"Infiltrative lipoma in dogs","volume":"17","author":"McChesney AE","year":"1980","unstructured":"McChesney AE, Stephens LC, Lebel J, Snyder S, Ferguson HR. Infiltrative lipoma in dogs. Vet Pathol. 1980;17(3):316-322. doi:10.1177\/030098588001700305"},{"issue":"5","key":"ref2","series-title":"Vet Pathol","first-page":"623","article-title":"Infiltrating lipomas in the dog","volume":"16","author":"Gleiser CA","year":"1979","unstructured":"Gleiser CA, Jardine JH, Raulston GL, Gray KN. Infiltrating lipomas in the dog. Vet Pathol. 1979;16(5):623-624. doi:10.1177\/030098587901600519"},{"issue":"1","key":"ref3","series-title":"J Am Vet Med Assoc","first-page":"81","article-title":"Infiltrative lipoma in three dogs","volume":"186","author":"Kramek BA","year":"1985","unstructured":"Kramek BA, Spackman JA, Hayden DW. Infiltrative lipoma in three dogs. J Am Vet Med Assoc. 1985;186(1):81-82."},{"issue":"2","key":"ref4","series-title":"J Am Vet Med Assoc","first-page":"322","article-title":"Infiltrative lipoma in dogs: 16 cases (1981-1992)","volume":"205","author":"Bergman PJ","year":"1994","unstructured":"Bergman PJ, Withrow SJ, Straw RC, Powers BE. 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Int J Radiat Oncol Biol Phys. 2010;76(suppl 3):S70-S76. doi:10.1016\/j.ijrobp.2009.06.091"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/261\/11\/javma.23.05.0288.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/261\/11\/javma.23.05.0288.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/261\/11\/javma.23.05.0288.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T08:03:55Z","timestamp":1741334635000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/261\/11\/javma.23.05.0288.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,1]]},"references-count":27,"journal-issue":{"issue":"11"},"URL":"https:\/\/doi.org\/10.2460\/javma.23.05.0288","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11,1]]}}}