{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:36:57Z","timestamp":1788568617914,"version":"build-2803163510"},"reference-count":29,"publisher":"American Veterinary Medical Association (AVMA)","issue":"S2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"sc_a1\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Determine diagnostic yield of chest, abdomen, and 4-site screening to diagnose metastatic disease and secondary diseases of prognostic significance in dogs with oral cancer.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a2\">\n<jats:title>SAMPLE<\/jats:title>\n<jats:p>Medical records from 381 dogs with histologically confirmed oral tumors that underwent preoperative screening were retrospectively reviewed.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a3\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Thoracic metastasis was diagnosed in 4.9% (0.9% odontogenic, 6.5% nonodontogenic) of oral tumors. Oral malignant melanoma and multilobular osteochondrosarcoma were most at risk. Abdominal metastasis was diagnosed in 2% of oral tumors (0% odontogenic, 3.1% nonodontogenic) and cytologically confirmed in 2 cases (0.6% [2\/295)] of all abdominal ultrasounds (AUS) 5.5% [2\/36] of all AUS that had cytology). Both cases had oral malignant melanoma. Incidental disease was diagnosed in 53.1% and 81.3% of thoracic and abdominal screenings, respectively. Major findings were more common in AUS (7.8%) compared to thoracic screening (1.9%). The prevalence of incidental findings was similar for odontogenic and nonodontogenic tumors. Both metastasis and major findings were diagnosed more commonly with thoracic CT compared to radiographs. Metastasis or a major finding of prognostic significance was diagnosed in at least 1 test in 27.8% of patients that had head CT, lymph node cytology, thoracic screening, and AUS (n = 115).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a4\">\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Major incidental findings were more commonly detected with AUS and were diagnosed in 1 in every 12 patients. However, metastatic disease was most commonly detected with thoracic screening. When all 4 screening tests are performed, there is an approximately 1 in 4 chance of diagnosing metastasis or major significant disease regardless of tumor type.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.23.05.0300","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T12:14:50Z","timestamp":1695903290000},"page":"S24-S33","source":"Crossref","is-referenced-by-count":7,"title":["The diagnostic yield of preoperative screening for oral cancer in dogs over 15 years, part 2: distant screening"],"prefix":"10.2460","volume":"261","author":[{"given":"Stephanie","family":"Goldschmidt","sequence":"first","affiliation":[{"name":"Department of Surgical and Radiologic Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Soltero-Rivera","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiologic Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Quiroz","sequence":"additional","affiliation":[{"name":"College of Agriculture and Environmental Sciences, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Wong","sequence":"additional","affiliation":[{"name":"College of Agriculture and Environmental Sciences, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Rebhun","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiologic Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Zwingenberger","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiologic Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyi","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology, and Research Design, Clinical and Translation Science Center, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology, and Research Design, Clinical and Translation Science Center, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boaz","family":"Arzi","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiologic Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"B1","series-title":"Front Vet Sci","first-page":"506","article-title":"Variability in recommendations for cervical lymph node pathology for staging of canine oral neoplasia: a survey study","volume":"7","author":"Congiusta M","year":"2020","unstructured":"Congiusta M, Lawrence J, Rendahl A, Goldschmidt S. 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