{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T11:50:10Z","timestamp":1782733810640,"version":"3.54.5"},"reference-count":38,"publisher":"American Veterinary Medical Association (AVMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>This study aimed to evaluate the safety and feasibility of intranasal administration of dexmedetomidine as a premedication for preventing hypotension and hypothermia in canine patients undergoing MRI examinations.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>Dogs undergoing MRI examinations for neurological disorders were enrolled in this study. The dogs were randomly assigned: 15 to the N-Dex group (without premedication) and 13 to the Dex group (125 \u03bcg\/m<jats:sup>2<\/jats:sup> of dexmedetomidine, intranasally, as a premedication).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>During the examination, pulse rate, systolic blood pressure, diastolic blood pressure, and mean arterial blood pressure were recorded every 5 minutes for the first 30 minutes. Body temperature was measured before and after the examination. Any adverse events during the procedure were documented.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Significant changes in pulse rate during the examination were not distinguishable. Although blood pressure and body temperature decreased in both groups under anesthesia, dogs in the Dex group had a significantly smaller drop in blood pressure and body temperature and fewer hypotension events than those in the N-Dex group MRI examinations of 1 hour\u2019s duration. Two dogs in the Dex group exhibited bradycardia at 45 and 60 minutes of MRI examination, which resolved after receiving atipamezole.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Our results indicate that intranasal administration of 125 \u03bcg\/m<jats:sup>2<\/jats:sup> of dexmedetomidine as premedication is safe and can potentially mitigate hypothermia and hypotension in dogs with neurological disorders during MRI examinations.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.23.06.0322","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T19:35:33Z","timestamp":1698262533000},"page":"193-200","source":"Crossref","is-referenced-by-count":3,"title":["Intranasal dexmedetomidine as premedication for magnetic resonance imaging examinations in dogs with neurological disorders mitigates hypotension and hypothermia"],"prefix":"10.2460","volume":"262","author":[{"given":"Pei-Jyuan","family":"Lin","sequence":"first","affiliation":[{"name":"Veterinary Medical Teaching Hospital, National Pingtung University of Science and Technology, Pingtung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee-Shuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Veterinary Medical Teaching Hospital, National Pingtung University of Science and Technology, Pingtung, Taiwan"},{"name":"School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"},{"name":"Department of Medical Imaging and Radiological Sciences, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan"},{"name":"UniCore Animal Hospital, Taipei City, Taiwan"},{"name":"Department of Veterinary Medicine, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Shu","family":"Chung","sequence":"additional","affiliation":[{"name":"Veterinary Medical Teaching Hospital, National Pingtung University of Science and Technology, Pingtung, Taiwan"},{"name":"UniCore Animal Hospital, Taipei City, Taiwan"},{"name":"Department of Veterinary Medicine, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"9","key":"ref1","series-title":"J Vet Med A Physiol Pathol Clin Med","first-page":"470","article-title":"Normal values and incidence of cardiorespiratory complications in dogs during general anaesthesia: a review of 1281 cases","volume":"54","author":"Redondo JI","year":"2007","unstructured":"Redondo JI, Rubio M, Soler G, Serra I, Soler C, G\u00f3mez-Villamandos RJ. Normal values and incidence of cardiorespiratory complications in dogs during general anaesthesia: a review of 1281 cases. J Vet Med A Physiol Pathol Clin Med. 2007;54(9):470-477. doi:10.1111\/j.1439-0442.2007.00987.x"},{"issue":"1","key":"ref2","series-title":"Neuroscience","first-page":"79","article-title":"Isoflurane increases norepinephrine release in the rat preoptic area and the posterior hypothalamus in vivo and in vitro: relevance to thermoregulation during anesthesia","volume":"131","author":"Kushikata T","year":"2005","unstructured":"Kushikata T, Hirota K, Kotani N, Yoshida H, Kudo M, Matsuki A. Isoflurane increases norepinephrine release in the rat preoptic area and the posterior hypothalamus in vivo and in vitro: relevance to thermoregulation during anesthesia. Neuroscience. 2005;131(1):79-86. doi:10.1016\/j.neuroscience.2004.11.007"},{"issue":"1","key":"ref3","series-title":"Vet J","first-page":"289","article-title":"Incidence of intraoperative hypotension during isoflurane-fentanyl and propofol-fentanyl anaesthesia in dogs","volume":"198","author":"Iizuka T","year":"2013","unstructured":"Iizuka T, Kamata M, Yanagawa M, Nishimura R. Incidence of intraoperative hypotension during isoflurane-fentanyl and propofol-fentanyl anaesthesia in dogs. Vet J. 2013;198(1):289-291. doi:10.1016\/j.tvjl.2013.06.021"},{"issue":"1","key":"ref4","series-title":"J Am Anim Hosp Assoc","first-page":"13","article-title":"Complications and mortality associated with anesthesia in dogs and cats","volume":"35","author":"Gaynor JS","year":"1999","unstructured":"Gaynor JS, Dunlop CI, Wagner AE, Wertz EM, Golden AE, Demme WC. Complications and mortality associated with anesthesia in dogs and cats. J Am Anim Hosp Assoc. 1999;35(1):13-17. doi:10.5326\/15473317-35-1-13"},{"issue":"15","key":"ref5","series-title":"Vet Rec","first-page":"374","article-title":"Retrospective study of the prevalence of postanaesthetic hypothermia in dogs","volume":"171","author":"Redondo JI","year":"2012","unstructured":"Redondo JI, Suesta P, Serra I,  Retrospective study of the prevalence of postanaesthetic hypothermia in dogs. Vet Rec. 2012;171(15):374. doi:10.1136\/vr.100476"},{"issue":"3","key":"ref6","series-title":"Anesth Analg","first-page":"826","article-title":"Predictor of core hypothermia and the surgical intensive care unit","volume":"96","author":"Kongsayreepong S","year":"2003","unstructured":"Kongsayreepong S, Chaibundit C, Chadpaibool J,  Predictor of core hypothermia and the surgical intensive care unit. Anesth Analg. 2003;96(3):826-833. doi:10.1213\/01.ANE.0000048822.27698.28"},{"issue":"5","key":"ref7","series-title":"Anesthesiology","first-page":"533","article-title":"Isoflurane for neuroanesthesia: risk factors for increases in intracranial pressure","volume":"63","author":"Grosslight K","year":"1985","unstructured":"Grosslight K, Foster R, Colohan AR, Bedford RF. Isoflurane for neuroanesthesia: risk factors for increases in intracranial pressure. Anesthesiology. 1985;63(5):533-536. doi:10.1097\/00000542-198511000-00011"},{"issue":"8","key":"ref8","series-title":"Animals (Basel)","first-page":"2378","article-title":"Effect of an insulation device in preventing hypothermia during magnetic resonance imaging examinations for dogs and cats under general anesthesia","volume":"11","author":"Onozawa E","year":"2021","unstructured":"Onozawa E, Azakami D, Seki S, Hamamoto Y, Ishioka K. Effect of an insulation device in preventing hypothermia during magnetic resonance imaging examinations for dogs and cats under general anesthesia. Animals (Basel). 2021;11(8):2378. doi:10.3390\/ani11082378"},{"issue":"12","key":"ref9","series-title":"Vet Sci","first-page":"660","article-title":"Effect of hot water bottles on body temperature during magnetic resonance imaging in dogs under general anesthesia: a retrospective study","volume":"9","author":"Shimizu Y","year":"2022","unstructured":"Shimizu Y, Kanda T, Kutara K,  Effect of hot water bottles on body temperature during magnetic resonance imaging in dogs under general anesthesia: a retrospective study. Vet Sci. 2022;9(12):660. doi:10.3390\/vetsci9120660"},{"issue":"2","key":"ref10","series-title":"Shock","first-page":"115","article-title":"The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategies","volume":"26","author":"Cotton BA","year":"2006","unstructured":"Cotton BA, Guy JS, Morris JA Jr, Abumrad NN. The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategies. Shock. 2006;26(2):115-121. doi:10.1097\/01.shk.0000209564.84822.f2"},{"issue":"4","key":"ref11","series-title":"Br J Anaesth","first-page":"622","article-title":"Pathophysiology and clinical implications of perioperative fluid excess","volume":"89","author":"Holte K","year":"2002","unstructured":"Holte K, Sharrock NE, Kehlet H. Pathophysiology and clinical implications of perioperative fluid excess. Br J Anaesth. 2002;89(4):622-632. doi:10.1093\/bja\/aef220"},{"issue":"7","key":"ref12","series-title":"Crit Care Med","first-page":"728","article-title":"Postoperative fluid overload: not a benign problem","volume":"18","author":"Lowell JA","year":"1990","unstructured":"Lowell JA, Schifferdecker C, Driscoll DF, Benotti PN, Bistrian BR. Postoperative fluid overload: not a benign problem. Crit Care Med. 1990;18(7):728-733. doi:10.1097\/00003246-199007000-00010"},{"issue":"7","key":"ref13","series-title":"Am J Vet Res","first-page":"1121","article-title":"Impact of dopamine or dobutamine infusions on cardiovascular variables after rapid blood loss and volume replacement during isoflurane-induced anesthesia in dogs","volume":"67","author":"Dyson DH","year":"2006","unstructured":"Dyson DH, Sinclair MD. Impact of dopamine or dobutamine infusions on cardiovascular variables after rapid blood loss and volume replacement during isoflurane-induced anesthesia in dogs. Am J Vet Res. 2006;67(7):1121-1130. doi:10.2460\/ajvr.67.7.1121"},{"issue":"1","key":"ref14","series-title":"J Vet Pharmacol Ther","first-page":"15","article-title":"Clinical effects and pharmacokinetics of medetomidine and its enantiomers in dogs","volume":"23","author":"Kuusela E","year":"2000","unstructured":"Kuusela E, Raekallio M, Anttila M, Falck I, M\u00f6ls\u00e4 S, Vainio O. Clinical effects and pharmacokinetics of medetomidine and its enantiomers in dogs. J Vet Pharmacol Ther. 2000;23(1):15-20. doi:10.1046\/j.1365-2885.2000.00245.x"},{"issue":"7","key":"ref15","series-title":"J Am Vet Med Assoc","first-page":"754","article-title":"Hemodynamic influence of acepromazine or dexmedetomidine premedication in isoflurane-anesthetized dogs","volume":"246","author":"Grasso SC","year":"2015","unstructured":"Grasso SC, Ko JC, Weil AB, Paranjape V, Constable PD. Hemodynamic influence of acepromazine or dexmedetomidine premedication in isoflurane-anesthetized dogs. J Am Vet Med Assoc. 2015;246(7):754-764. doi:10.2460\/javma.246.7.754"},{"issue":"2","key":"ref16","series-title":"J Pharmacol Exp Ther","first-page":"690","article-title":"Hemodynamic and sedative effects of dexmedetomidine in dog","volume":"263","author":"Bloor BC","year":"1992","unstructured":"Bloor BC, Frankland M, Alper G, Raybould D, Weitz J, Shurtliff M. Hemodynamic and sedative effects of dexmedetomidine in dog. J Pharmacol Exp Ther. 1992;263(2):690-697."},{"issue":"4","key":"ref17","series-title":"Vet Anaesth Analg","first-page":"755","article-title":"Effects of constant rate infusions of dexmedetomidine or MK-467 on the minimum alveolar concentration of sevoflurane in dogs","volume":"44","author":"Hector RC","year":"2017","unstructured":"Hector RC, Rezende ML, Mama KR,  Effects of constant rate infusions of dexmedetomidine or MK-467 on the minimum alveolar concentration of sevoflurane in dogs. Vet Anaesth Analg. 2017;44(4):755-765. doi:10.1016\/j.vaa.2016.12.058"},{"issue":"3","key":"ref18","series-title":"Vet Anaesth Analg","first-page":"452","article-title":"Do heat and moisture exchangers in the anaesthesia breathing circuit preserve body temperature in dogs undergoing anaesthesia for magnetic resonance imaging?","volume":"44","author":"Khenissi L","year":"2017","unstructured":"Khenissi L, Covey-Crump G, Knowles TG, Murrell J. Do heat and moisture exchangers in the anaesthesia breathing circuit preserve body temperature in dogs undergoing anaesthesia for magnetic resonance imaging? Vet Anaesth Analg. 2017;44(3):452-460. doi:10.1016\/j.vaa.2016.05.016"},{"issue":"7","key":"ref19","series-title":"Can Vet J","first-page":"729","article-title":"Cardiovascular effects of constant rate infusions of lidocaine, lidocaine and dexmedetomidine, and dexmedetomidine in dogs anesthetized at equipotent doses of sevoflurane","volume":"58","author":"Moran-Mu\u00f1oz R","year":"2017","unstructured":"Moran-Mu\u00f1oz R, Valverde A, Ibancovichi JA,  Cardiovascular effects of constant rate infusions of lidocaine, lidocaine and dexmedetomidine, and dexmedetomidine in dogs anesthetized at equipotent doses of sevoflurane. Can Vet J. 2017;58(7):729-734."},{"issue":"1","key":"ref20","series-title":"Vet Rec Case Rep","first-page":"e000727","article-title":"Dexmedetomidine infusion as perioperative adjuvant in a dog undergoing craniotomy","volume":"7","author":"Tayari H","year":"2019","unstructured":"Tayari H, Bell A. Dexmedetomidine infusion as perioperative adjuvant in a dog undergoing craniotomy. Vet Rec Case Rep. 2019;7(1):e000727. doi:10.1136\/vetreccr-2018-000727"},{"issue":"2","key":"ref21","series-title":"Anesth Analg","first-page":"370","article-title":"Intravenous dexmedetomidine inhibits cerebrovascular dilation induced by isoflurane and sevoflurane in dogs","volume":"89","author":"Ohata H","year":"1999","unstructured":"Ohata H, Iida H, Dohi S, Watanabe Y. Intravenous dexmedetomidine inhibits cerebrovascular dilation induced by isoflurane and sevoflurane in dogs. Anesth Analg. 1999;89(2):370-377. doi:10.1213\/00000539-199908000-00023"},{"issue":"26","key":"ref22","series-title":"Vet Rec","first-page":"891","article-title":"Evaluation of the clinical efficacy and safety of intramuscular and intravenous doses of dexmedetomidine and medetomidine in dogs and their reversal with atipamezole","volume":"160","author":"Granholm M","year":"2007","unstructured":"Granholm M, McKusick BC, Westerholm FC, Aspegr\u00e9n JC. Evaluation of the clinical efficacy and safety of intramuscular and intravenous doses of dexmedetomidine and medetomidine in dogs and their reversal with atipamezole. Vet Rec. 2007;160(26):891-897. doi:10.1136\/vr.160.26.891"},{"issue":"2","key":"ref23","series-title":"J Anaesthesiol Clin Pharmacol","first-page":"179","article-title":"A comparative study to evaluate the effect of intranasal dexmedetomidine versus oral alprazolam as a premedication agent in morbidly obese patients undergoing bariatric surgery","volume":"29","author":"Jayaraman L","year":"2013","unstructured":"Jayaraman L, Sinha A, Punhani D. A comparative study to evaluate the effect of intranasal dexmedetomidine versus oral alprazolam as a premedication agent in morbidly obese patients undergoing bariatric surgery. J Anaesthesiol Clin Pharmacol. 2013;29(2):179-182. doi:10.4103\/0970-9185.111680"},{"issue":"4","key":"ref24","series-title":"Vet Anaesth Analg","first-page":"703","article-title":"Sedative and cardiovascular effects of intranasal or intramuscular dexmedetomidine in healthy dogs","volume":"44","author":"Micieli F","year":"2017","unstructured":"Micieli F, Santangelo B, Reynaud F,  Sedative and cardiovascular effects of intranasal or intramuscular dexmedetomidine in healthy dogs. Vet Anaesth Analg. 2017;44(4):703-709. doi:10.1016\/j.vaa.2016.08.009"},{"issue":"1","key":"ref25","series-title":"J Anesth","first-page":"12","article-title":"Comparison between intranasal dexmedetomidine and intranasal ketamine as premedication for procedural sedation in children undergoing MRI: a double-blind, randomized, placebo-controlled trial","volume":"28","author":"Gyanesh P","year":"2014","unstructured":"Gyanesh P, Haldar R, Srivastava D, Agrawal PM, Tiwari AK, Singh PK. Comparison between intranasal dexmedetomidine and intranasal ketamine as premedication for procedural sedation in children undergoing MRI: a double-blind, randomized, placebo-controlled trial. J Anesth. 2014;28(1):12-18. doi:10.1007\/s00540-013-1657-x"},{"issue":"6","key":"ref26","series-title":"Paediatr Drugs","first-page":"479","article-title":"Comparison of two different intranasal doses of dexmedetomidine in children for magnetic resonance imaging sedation","volume":"17","author":"Tug A","year":"2015","unstructured":"Tug A, Hanci A, Turk HS,  Comparison of two different intranasal doses of dexmedetomidine in children for magnetic resonance imaging sedation. Paediatr Drugs. 2015;17(6):479-485. doi:10.1007\/s40272-015-0145-1"},{"issue":"4","key":"ref27","series-title":"Am J Physiol","first-page":"F329","article-title":"Drainage of cerebral interstitial fluid into deep cervical lymph of the rabbit","volume":"240","author":"Bradbury MW","year":"1981","unstructured":"Bradbury MW, Cserr HF, Westrop RJ. Drainage of cerebral interstitial fluid into deep cervical lymph of the rabbit. Am J Physiol. 1981;240(4):F329-F336."},{"issue":"6","key":"ref28","series-title":"Neuropathol Appl Neurobiol","first-page":"480","article-title":"CSF drains directly from the subarachnoid space into nasal lymphatics in the rat. Anatomy, histology and immunological significance","volume":"19","author":"Kida S","year":"1993","unstructured":"Kida S, Pantazis A, Weller RO. CSF drains directly from the subarachnoid space into nasal lymphatics in the rat. Anatomy, histology and immunological significance. Neuropathol Appl Neurobiol. 1993;19(6):480-488. doi:10.1111\/j.1365-2990.1993.tb00476.x"},{"issue":"4","key":"ref29","series-title":"Arch Otolaryngol","first-page":"180","article-title":"Subarachnoid space of the CNS, nasal mucosa, and lymphatic system","volume":"105","author":"Jackson RT","year":"1979","unstructured":"Jackson RT, Tigges J, Arnold W. Subarachnoid space of the CNS, nasal mucosa, and lymphatic system. Arch Otolaryngol. 1979;105(4):180-184. doi:10.1001\/archotol.1979.00790160014003"},{"issue":"1-2","key":"ref30","series-title":"Adv Drug Deliv Rev","first-page":"89","article-title":"Effects of physicochemical properties and other factors on systemic nasal drug delivery","volume":"29","author":"Romeo VD","year":"1998","unstructured":"Romeo VD, deMeireles J, Sileno AP, Pimplaskar HK, Behl CR. Effects of physicochemical properties and other factors on systemic nasal drug delivery. Adv Drug Deliv Rev. 1998;29(1-2):89-116. doi:10.1016\/S0169-409X(97)00063-X"},{"issue":"5","key":"ref31","series-title":"Br J Anaesth","first-page":"601","article-title":"Calculation of drug dosage and body surface area of children","volume":"78","author":"Lack JA","year":"1997","unstructured":"Lack JA, Stuart-Taylor ME. Calculation of drug dosage and body surface area of children. Br J Anaesth. 1997;78(5):601-605. doi:10.1093\/bja\/78.5.601"},{"issue":"9","key":"ref32","series-title":"Nursing","first-page":"51","article-title":"Take a deeper look into body surface area","volume":"49","author":"Smith LS","year":"2019","unstructured":"Smith LS. Take a deeper look into body surface area. Nursing. 2019;49(9):51-54. doi:10.1097\/01.NURSE.0000558092.00476.db"},{"key":"ref33","series-title":"Vet J","first-page":"56","article-title":"Comparison of sedation scores and propofol induction doses in dogs after intramuscular administration of dexmedetomidine alone or in combination with methadone, midazolam, or methadone plus midazolam","volume":"210","author":"Canfr\u00e1n S","year":"2016","unstructured":"Canfr\u00e1n S, Bustamante R, Gonz\u00e1lez P, Cediel R, Re M, de Segura IA. Comparison of sedation scores and propofol induction doses in dogs after intramuscular administration of dexmedetomidine alone or in combination with methadone, midazolam, or methadone plus midazolam. Vet J. 2016;210:56-60. doi:10.1016\/j.tvjl.2016.01.015"},{"issue":"6","key":"ref34","series-title":"Vet Anaesth Analg","first-page":"572","article-title":"Comparison of the sedative effects of intranasal or intramuscular dexmedetomidine at low doses in healthy dogs: a randomized clinical trial","volume":"49","author":"L\u00f3pez-Ramis V","year":"2022","unstructured":"L\u00f3pez-Ramis V, Canfr\u00e1n S, G\u00f3mez de Segura IA. Comparison of the sedative effects of intranasal or intramuscular dexmedetomidine at low doses in healthy dogs: a randomized clinical trial. Vet Anaesth Analg. 2022;49(6):572-579. doi:10.1016\/j.vaa.2022.08.003"},{"issue":"8","key":"ref35","series-title":"Am J Vet Res","first-page":"885","article-title":"Cardiopulmonary effects of sevoflurane, compared with halothane, enflurane, and isoflurane, in dogs","volume":"58","author":"Mutoh T","year":"1997","unstructured":"Mutoh T, Nishimura R, Kim HY, Matsunaga S, Sasaki N. Cardiopulmonary effects of sevoflurane, compared with halothane, enflurane, and isoflurane, in dogs. Am J Vet Res. 1997;58(8):885-890."},{"issue":"1","key":"ref36","series-title":"J Vet Emerg Crit Care (San Antonio)","first-page":"32","article-title":"Perioperative hypothermia","volume":"15","author":"Armstrong SR","year":"2005","unstructured":"Armstrong SR, Roberts BK, Aronsohn M. Perioperative hypothermia. J Vet Emerg Crit Care (San Antonio). 2005;15(1):32-37. doi:10.1111\/j.1476-4431.2005.04033.x"},{"key":"ref37","series-title":"Vet J","first-page":"105346","article-title":"Intranasal dexmedetomidine in healthy Beagles: an echocardiographic and pharmacokinetic\/pharmacodynamic study","volume":"251","author":"Santangelo B","year":"2019","unstructured":"Santangelo B, Harel M, Fourel I,  Intranasal dexmedetomidine in healthy Beagles: an echocardiographic and pharmacokinetic\/pharmacodynamic study. Vet J. 2019;251:105346. doi:10.1016\/j.tvjl.2019.105346"},{"issue":"5","key":"ref38","series-title":"Br J Anaesth","first-page":"960","article-title":"Pharmacokinetic and pharmacodynamic study of intranasal and intravenous dexmedetomidine","volume":"120","author":"Li A","year":"2018","unstructured":"Li A, Yuen VM, Goulay-Dufa\u00ff S,  Pharmacokinetic and pharmacodynamic study of intranasal and intravenous dexmedetomidine. Br J Anaesth. 2018;120(5):960-968. doi:10.1016\/j.bja.2017.11.100"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/262\/2\/javma.23.06.0322.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/262\/2\/javma.23.06.0322.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/262\/2\/javma.23.06.0322.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T13:05:34Z","timestamp":1741352734000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/262\/2\/javma.23.06.0322.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,1]]},"references-count":38,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.2460\/javma.23.06.0322","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2,1]]}}}