{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T04:31:01Z","timestamp":1727325061531},"reference-count":21,"publisher":"American Veterinary Medical Association (AVMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>The objective of this study was to determine hematologic changes of stored caprine whole blood in citrate phosphate dextrose adenine solution over a 28-day period.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>SAMPLE<\/jats:title>\n<jats:p>Ten 250-mL bags of whole blood were collected from 10 female Boer goats from Louisiana State University\u2019s Division of Laboratory Animal Medicine herd.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>10 healthy blood donor goats were selected, and 250 mL of whole blood was drawn from each and stored at 2.78 \u00b0C. At the time of collection and every 7 days for a total of 28 days, samples were obtained from the blood bags to determine biochemical and hematologic values of collected blood. Only 5 of the 10 donors had baseline blood bag samples obtained for biochemical evaluation on day 0. At the end of 28 days, the remaining blood was submitted for aerobic and anaerobic culture.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Blood values remained within suitable limits for transfusion and below 1% hemolysis for up to 21 days in most samples. Packed cell volume did not change significantly from day 0 to day 28. Lactate significantly increased over the 28 days, though not as dramatically as expected on the basis of other blood storage studies. pH decreased due to anticoagulant acidity but did not drop below 7. Cultures were negative on all blood bags.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Changes over time are similar to that in other species, and caprine blood appears biochemically and hematologically stable for up to 21 days in storage. In vivo trials are needed for safety and efficacy.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.23.08.0434","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T14:44:05Z","timestamp":1704293045000},"page":"391-396","source":"Crossref","is-referenced-by-count":0,"title":["Caprine whole blood appears sufficiently stable after 21 days in storage to be suitable for transfusion"],"prefix":"10.2460","volume":"262","author":[{"given":"Hannah M.","family":"Neill","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare M.","family":"Scully","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-Chi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose E.","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"5","key":"ref1","series-title":"Vet Surg","first-page":"475","article-title":"Comparison of 4 blood storage methods in a protocol for equine pre-operative autologous donation","volume":"33","author":"Mudge MC","year":"2004","unstructured":"Mudge MC, Macdonald MH, Owens SD, Tablin F. Comparison of 4 blood storage methods in a protocol for equine pre-operative autologous donation. Vet Surg. 2004;33(5):475-486. doi:10.1111\/j.1532-950X.2004.04070.x"},{"issue":"2","key":"ref2","series-title":"Vet Clin Pathol","first-page":"221","article-title":"Biochemical and hematologic changes in whole blood from Brazilian horses stored in citrate-phosphate-dextrose-adenine pouches for up to 28 days","volume":"50","author":"Dorneles TEA","year":"2021","unstructured":"Dorneles TEA, Costa Junior JD, Almeida RM, Teixeira Neto AR. Biochemical and hematologic changes in whole blood from Brazilian horses stored in citrate-phosphate-dextrose-adenine pouches for up to 28 days. 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