{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:55:03Z","timestamp":1793130903385,"version":"4.5.0"},"reference-count":37,"publisher":"American Veterinary Medical Association (AVMA)","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To describe the clinical findings, microbiological data, treatment, and outcome of a population of cats with suspected acute pyelonephritis (APN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>ANIMALS<\/jats:title>\n                    <jats:p>32 client-owned cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CLINICAL PRESENTATION AND PROCEDURES<\/jats:title>\n                    <jats:p>Retrospective case series from 2 veterinary teaching hospitals between January 1, 2014, and December 31, 2020. Cats were included if they had a positive bacterial urine culture and a clinical diagnosis of acute kidney injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Older female cats with underlying chronic kidney disease have a higher probability to develop bacterial culture\u2013positive acute kidney injury or APN.\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                      was the most commonly cultured bacterial species, and\n                      <jats:italic>E coli<\/jats:italic>\n                      isolates with susceptibility testing were resistant to amoxicillin-clavulanate but susceptible to fluoroquinolones or third-generation cephalosporins. Of the 20 cats with available follow-up information in the medical record, 14 were alive at 3 months after hospital discharge. Markers of renal function including creatinine (\n                      <jats:italic>P<\/jats:italic>\n                      = .008), BUN (\n                      <jats:italic>P<\/jats:italic>\n                      = .005), and phosphorus (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001) at the time of presentation were all higher in nonsurvivors compared with survivors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CLINICAL RELEVANCE<\/jats:title>\n                    <jats:p>The survival rate with feline APN is higher than previous reports of acute kidney injury when all etiologies are considered. Nonsurvivors had more pronounced azotemia upon initial presentation. Amoxicillin-clavulanate was a poor empirical antimicrobial in this cohort based on the microbiological data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/javma.23.08.0488","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T09:51:07Z","timestamp":1700128267000},"page":"232-240","source":"Crossref","is-referenced-by-count":8,"title":["Acute pyelonephritis in cats is frequently caused by Escherichia coli resistant to potentiated penicillins but has a better prognosis than other causes of acute kidney injury"],"prefix":"10.2460","volume":"262","author":[{"given":"William H.","family":"Whitehouse","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby L.","family":"Ostronic","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina R.","family":"Viviano","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"5","key":"ref1","series-title":"J Am Vet Med Assoc","first-page":"728","article-title":"Acute intrinsic renal failure in cats: 32 cases (1997-2004)","volume":"232","author":"Worwag S","year":"2008","unstructured":"Worwag S, Langston CE. 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