{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T09:58:27Z","timestamp":1768643907711,"version":"3.49.0"},"reference-count":5,"publisher":"American Veterinary Medical Association (AVMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To describe the clinical presentation, progression, and diagnosis of acute myeloid leukemia (AML) with neutrophilic differentiation in an African lion (<jats:italic>Panthera leo<\/jats:italic>).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>ANIMAL<\/jats:title>\n<jats:p>A 12-year-old male African lion kept at a zoological institution in Colombia.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL PRESENTATION, PROGRESSION, AND PROCEDURES<\/jats:title>\n<jats:p>The lion presented for anorexia, pale mucous membranes, and a hind limb lameness of acute onset. Feline leukemia virus testing was negative, and repeated blood samples revealed severe anemia, intermittent thrombocytopenia, lymphopenia, and neutrophilia. Coinfection with <jats:italic>Anaplasma<\/jats:italic> and <jats:italic>Mycoplasma<\/jats:italic> spp and chronic kidney disease were diagnosed based on clinicopathological findings.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>TREATMENT AND OUTCOME<\/jats:title>\n<jats:p>The lion received symptomatic treatment, doxycycline, and methylprednisolone or prednisolone. Euthanasia was elected due to clinical deterioration and unresponsive anemia, despite the resolution of <jats:italic>Anaplasma<\/jats:italic> and <jats:italic>Mycoplasma<\/jats:italic> spp infections. AML with neutrophilic differentiation was diagnosed based on bone marrow cytology, histopathology, and immunohistochemistry.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>AML is a rare, aggressive hematopoietic disorder in domestic cats, although it has not yet been reported in nondomestic cats. This is the first description of the clinicopathological, histological, and immunohistochemical features of AML with neutrophilic differentiation in an FeLV-negative African lion that lacked circulating blasts.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.23.09.0530","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T14:44:12Z","timestamp":1704293052000},"page":"1-5","source":"Crossref","is-referenced-by-count":1,"title":["Acute myeloid leukemia with neutrophilic differentiation in a 12-year-old African lion (Panthera leo)"],"prefix":"10.2460","volume":"262","author":[{"given":"Daniela","family":"Losada-Medina","sequence":"first","affiliation":[{"name":"Facultad de Medicina Veterinaria y de Zootecnia, Universidad Nacional de Colombia, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana M.","family":"Henao-Duque","sequence":"additional","affiliation":[{"name":"Zoopath Laboratorio de Patolog\u00eda Veterinaria, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana I.","family":"Buitrago-Grisales","sequence":"additional","affiliation":[{"name":"Unit of Animal Welfare, Fundaci\u00f3n Zool\u00f3gica de Cali, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Pe\u00f1a-Stadlin","sequence":"additional","affiliation":[{"name":"Unit of Animal Welfare, Fundaci\u00f3n Zool\u00f3gica de Cali, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"1","key":"ref1","series-title":"In Pract","first-page":"28","article-title":"Diagnosis and management of leukaemia in dogs and cats","volume":"28","author":"Dobson J","year":"2006","unstructured":"Dobson J, Villiers E, Morris J. Diagnosis and management of leukaemia in dogs and cats. In Pract. 2006;28(1):28. doi:10.1136\/inpract.28.1.22"},{"issue":"5","key":"ref2","series-title":"Blood","first-page":"937","article-title":"The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes","volume":"114","author":"Vardiman JW","year":"2009","unstructured":"Vardiman JW, Thiele J, Arber DA,  The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood. 2009;114(5):937-951. doi:10.1182\/blood-2009-03-209262"},{"issue":"3","key":"ref3","series-title":"Comp Haematol Int","first-page":"125","article-title":"Classification of myeloproliferative disorders in cats using criteria proposed by the animal leukaemia study group: a retrospective study of 181 cases (1969-1992)","volume":"3","author":"Jain NC","year":"1993","unstructured":"Jain NC. 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