{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:44:24Z","timestamp":1790113464214,"version":"4.0.1"},"reference-count":29,"publisher":"American Veterinary Medical Association (AVMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To determine the prognostic value of serum C-reactive protein (CRP) in dogs with pancreatitis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>503 client-owned animals with pancreatic lipase immunoreactivity (PLI) &gt; 600 \u00b5g\/L.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Routine submissions to the Texas A&amp;M Gastrointestinal Laboratory were monitored for canine samples with PLI &gt; 600 \u00b5g\/L. Clinics were emailed 2 weeks after PLI measurement and asked the following questions: (1) was the dog hospitalized, and (2) is the patient alive? If a response was received, serum CRP concentration was measured using leftover serum.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Paired PLI and CRP results were available for 503 dogs. Median PLI was 984 \u00b5g\/L (range, 603 to 2,001 \u00b5g\/L); median CRP was 9.9 mg\/L (range, 9.9 to 395.3 mg\/L; ref: &lt; 10 mg\/L). Inpatient care was provided to 136 dogs (27.0%); 49 dogs (9.7%) died or were euthanized. Median PLI values for dogs that died versus survived were similar. Median CRP was higher in hospitalized dogs (36.1 vs 9.9 mg\/L; <jats:italic>P<\/jats:italic> &lt; .0001) and those that died (37.2 vs 9.9 mg\/L; <jats:italic>P<\/jats:italic> &lt; .0001). Compared to dogs with CRP &lt; 10 mg\/L, those with CRP &gt; 10 mg\/L were 5.3 times more likely to die (CI, 2.7 to 10.2) and 5.7 times (CI, 3.7 to 8.7) more likely to be hospitalized.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>In dogs with PLI &gt; 600 \u00b5g\/L, CRP &gt; 10 mg\/L was associated with increased risk of hospitalization or death. This biomarker may provide prognostic information in dogs with evidence of pancreatitis and guide decisions regarding hospitalization or referral.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.23.09.0533","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T16:55:26Z","timestamp":1701449726000},"page":"370-375","source":"Crossref","is-referenced-by-count":5,"title":["Prognostic value of C-reactive protein in dogs with elevated serum pancreatic lipase immunoreactivity concentrations"],"prefix":"10.2460","volume":"262","author":[{"given":"Sydney M.","family":"Oberholtzer","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey K.","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robynne","family":"Gomez","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg M.","family":"Steiner","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX"},{"name":"Gastrointestinal Laboratory, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"3","key":"ref1","series-title":"J Vet Intern Med","first-page":"847","article-title":"New insights into the etiology, risk factors, and pathogenesis of pancreatitis in dogs: potential impacts on clinical practice","volume":"36","author":"Cridge H","year":"2022","unstructured":"Cridge H, Lim SY, Alg\u00fcl H, Steiner JM. 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