{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:57:07Z","timestamp":1791608227961,"version":"4.3.4"},"reference-count":29,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To evaluate the incidence of surgical site infections (SSIs) in dogs undergoing a tibial plateau leveling osteotomy (TPLO) with silver-coated (SC) and noncoated (NC) TPLO plates.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>65 dogs (73 surgical procedures).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Client-owned dogs undergoing a TPLO procedure between November 2021 and May 2023 were prospectively enrolled. Dogs were randomly assigned either an SC or NC TPLO plate at the time of surgery. Follow-up was performed at 2 weeks and 8 weeks postoperatively by in-person examination, client questionnaire, or telephone interview. Dogs were followed up 100 days postoperatively for any incisional or implant complications.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Among 73 stifles that underwent a TPLO, the overall SSI rate was 8.2% (6\/73), with an infection rate of 14.3% (5\/35) in the NC group and 2.6% (1\/38) in the SC group; this difference was not significant (<jats:italic>P<\/jats:italic> = .17). Five of these infections were superficial, and only 1 deep SSI was recorded within the 100-day study period (NC group).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Although no significant difference was noted between the SC and NC groups, likely due to a small sample size and overall low infection rate, there was a trend showing a higher infection rate in the NC group. No conclusions can be drawn on the impact of silver coating on deep or organ\/space incisional infections due to the low incidence reported in this study (n = 1). Further investigation of SC TPLO implants in a larger and more long-term clinical study is warranted.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.23.10.0592","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T14:31:34Z","timestamp":1705501894000},"page":"1-7","source":"Crossref","is-referenced-by-count":3,"title":["Silver-coated tibial plateau leveling osteotomy implants do not improve surgical site infection rates over noncoated implants in a randomized trial in 73 canines"],"prefix":"10.2460","volume":"262","author":[{"given":"Danielle M.","family":"Engel","sequence":"first","affiliation":[{"name":"Surgery Department, Veterinary Specialty Center, Bannockburn, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette M.","family":"McCoy","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell A.","family":"Robbins","sequence":"additional","affiliation":[{"name":"Surgery Department, Veterinary Specialty Center, Bannockburn, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"5","key":"ref1","series-title":"J Am Vet Med Assoc","first-page":"586","article-title":"Results of a survey of Veterinary Orthopedic Society members on the preferred method for treating cranial cruciate ligament rupture in dogs weighing more than 15 kilograms (33 pounds)","volume":"253","author":"von Pfeil DJF","year":"2018","unstructured":"von Pfeil DJF, Kowaleski MP, Glassman M, Dejardin LM. Results of a survey of Veterinary Orthopedic Society members on the preferred method for treating cranial cruciate ligament rupture in dogs weighing more than 15 kilograms (33 pounds). J Am Vet Med Assoc. 2018;253(5):586-597. doi:10.2460\/javma.253.5.586"},{"issue":"5","key":"ref2","series-title":"Vet Surg","first-page":"999","article-title":"Timing of and risk factors for deep surgical site infection requiring implant removal following canine tibial plateau leveling osteotomy","volume":"50","author":"McDougall RA","year":"2021","unstructured":"McDougall RA, Spector DI, Hart RC, Dycus DL, Erb HN. Timing of and risk factors for deep surgical site infection requiring implant removal following canine tibial plateau leveling osteotomy. Vet Surg. 2021;50(5):999-1008. doi:10.1111\/vsu.13634"},{"issue":"8","key":"ref3","series-title":"Vet Surg","first-page":"E79","article-title":"A prospective, randomized, double-blinded, placebo-controlled clinical study on postoperative antibiotherapy in 150 arthroscopy-assisted tibial plateau leveling osteotomies in dogs","volume":"47","author":"Spencer DD","year":"2018","unstructured":"Spencer DD, Daye RM. A prospective, randomized, double-blinded, placebo-controlled clinical study on postoperative antibiotherapy in 150 arthroscopy-assisted tibial plateau leveling osteotomies in dogs. Vet Surg. 2018;47(8):E79-E87. doi:10.1111\/vsu.12958"},{"issue":"6","key":"ref4","series-title":"Vet Surg","first-page":"705","article-title":"Implant removal rate from infection after tibial plateau leveling osteotomy in dogs","volume":"41","author":"Gallagher AD","year":"2012","unstructured":"Gallagher AD, Mertens WD. Implant removal rate from infection after tibial plateau leveling osteotomy in dogs. Vet Surg. 2012;41(6):705-711. doi:10.1111\/j.1532-950X.2012.00971.x"},{"issue":"4","key":"ref5","series-title":"Vet Comp Orthop Traumatol","first-page":"260","article-title":"Outcome following removal of TPLO implants with surgical site infection","volume":"26","author":"Savicky R","year":"2013","unstructured":"Savicky R, Beale B, Murtaugh R, Swiderski-Hazlett J, Unis M. Outcome following removal of TPLO implants with surgical site infection. Vet Comp Orthop Traumatol. 2013;26(4):260-265. doi:10.3415\/VCOT-11-12-0177"},{"key":"ref6","article-title":"National Healthcare Safety Network","unstructured":"Surgical site infection (SSI) event. National Healthcare Safety Network. Accessed August 2, 2023. https:\/\/www.cdc.gov\/nhsn\/pdfs\/pscmanual\/9pscSSIcurrent.pdf"},{"issue":"4","key":"ref7","series-title":"Vet Surg","first-page":"460","article-title":"Predictive variables for complications after TPLO with stifle inspection by arthrotomy in 1000 consecutive dogs","volume":"39","author":"Fitzpatrick N","year":"2010","unstructured":"Fitzpatrick N, Solano MA. Predictive variables for complications after TPLO with stifle inspection by arthrotomy in 1000 consecutive dogs. Vet Surg. 2010;39(4):460-474. doi:10.1111\/j.1532-950X.2010.00663.x"},{"issue":"8","key":"ref8","series-title":"Vet Surg","first-page":"966","article-title":"Perioperative administration of antimicrobials during tibial plateau leveling osteotomy","volume":"43","author":"Nazarali A","year":"2014","unstructured":"Nazarali A, Singh A, Weese JS. Perioperative administration of antimicrobials during tibial plateau leveling osteotomy. Vet Surg. 2014;43(8):966-971. doi:10.1111\/j.1532-950X.2014.12269.x"},{"issue":"8","key":"ref9","series-title":"Vet Surg","first-page":"899","article-title":"Economic impact of tibial plateau leveling osteotomy surgical site infection in dogs","volume":"43","author":"Nicoll C","year":"2014","unstructured":"Nicoll C, Singh A, Weese JS. Economic impact of tibial plateau leveling osteotomy surgical site infection in dogs. Vet Surg. 2014;43(8):899-902. doi:10.1111\/j.1532-950X.2014.12175.x"},{"issue":"4","key":"ref10","series-title":"Vet Surg","first-page":"481","article-title":"Protocol changes to reduce implant-associated infection rate after tibial plateau leveling osteotomy: 703 dogs, 811 TPLO (2006-2014)","volume":"47","author":"Stine SL","year":"2018","unstructured":"Stine SL, Odum SM, Mertens WD. Protocol changes to reduce implant-associated infection rate after tibial plateau leveling osteotomy: 703 dogs, 811 TPLO (2006-2014). Vet Surg. 2018;47(4):481-489. doi:10.1111\/vsu.12796"},{"issue":"1","key":"ref11","series-title":"J Am Vet Med Assoc","first-page":"62","article-title":"Randomized, controlled clinical trial to assess the effect of antimicrobial-impregnated suture on the incidence of surgical site infections in dogs and cats","volume":"257","author":"Thieman Mankin KM","year":"2020","unstructured":"Thieman Mankin KM, Cohen ND. Randomized, controlled clinical trial to assess the effect of antimicrobial-impregnated suture on the incidence of surgical site infections in dogs and cats. J Am Vet Med Assoc. 2020;257(1):62-69. doi:10.2460\/javma.257.1.62"},{"issue":"3","key":"ref12","series-title":"Vet Surg","first-page":"464","article-title":"Surgical site infection-inflammation in dogs draped with a single-layer Kraton elastic seal extremity drape for stifle surgery","volume":"51","author":"Morgera AE","year":"2022","unstructured":"Morgera AE, Hoelzler MG, Scavelli TD, Hackett AL. Surgical site infection-inflammation in dogs draped with a single-layer Kraton elastic seal extremity drape for stifle surgery. Vet Surg. 2022;51(3):464-473. doi:10.1111\/vsu.13773"},{"issue":"4","key":"ref13","series-title":"Eur J Orthop Surg Traumatol","first-page":"483","article-title":"Silver-coated megaprostheses: review of the literature","volume":"27","author":"Schmidt-Braekling T","year":"2017","unstructured":"Schmidt-Braekling T, Streitbuerger A, Gosheger G,  Silver-coated megaprostheses: review of the literature. Eur J Orthop Surg Traumatol. 2017;27(4):483-489. doi:10.1007\/s00590-017-1933-9."},{"issue":"4","key":"ref14","series-title":"Vet Comp Orthop Traumatol","first-page":"347","article-title":"Evaluation of a silver-impregnated coating to inhibit colonization of orthopaedic implants by biofilm forming methicillin-resistant Staphylococcus pseudintermedius","volume":"29","author":"Azab MA","year":"2016","unstructured":"Azab MA, Allen MJ, Daniels JB. Evaluation of a silver-impregnated coating to inhibit colonization of orthopaedic implants by biofilm forming methicillin-resistant Staphylococcus pseudintermedius. Vet Comp Orthop Traumatol. 2016;29(4):347-350. doi:10.3415\/VCOT-15-08-0134"},{"key":"ref15","series-title":"BioMed Res Int","first-page":"292406","article-title":"Evaluation of osseous integration of PVD-silver-coated hip prostheses in a canine model","volume":"2015","author":"Hauschild G","year":"2015","unstructured":"Hauschild G, Hardes J, Gosheger G,  Evaluation of osseous integration of PVD-silver-coated hip prostheses in a canine model. BioMed Res Int. 2015;2015:292406. doi:10.1155\/2015\/292406"},{"issue":"6","key":"ref16","series-title":"Materials (Basel)","first-page":"1415","article-title":"Antimicrobial silver multilayer coating for prevention of bacterial colonization of orthopedic implants","volume":"13","author":"Fabritius M","year":"2020","unstructured":"Fabritius M, Al-Munajjed AA, Freytag C,  Antimicrobial silver multilayer coating for prevention of bacterial colonization of orthopedic implants. Materials (Basel). 2020;13(6):1415. doi:10.3390\/ma13061415"},{"issue":"1","key":"ref17","series-title":"J Biomed Mater Res B Appl Biomater","first-page":"196","article-title":"Ag\/SiO(x)C(y) plasma polymer coating for antimicrobial protection of fracture fixation devices","volume":"94","author":"Khalilpour P","year":"2010","unstructured":"Khalilpour P, Lampe K, Wagener M,  Ag\/SiO(x)C(y) plasma polymer coating for antimicrobial protection of fracture fixation devices. J Biomed Mater Res B Appl Biomater. 2010;94(1):196-202. doi:10.1002\/jbm.b.31641"},{"issue":"2","key":"ref18","series-title":"Expert Opin Ther Pat","first-page":"125","article-title":"Silver and its application as an antimicrobial agent","volume":"15","author":"Melaiye A","year":"2005","unstructured":"Melaiye A, Youngs WJ. Silver and its application as an antimicrobial agent. Expert Opin Ther Pat. 2005;15(2):125-130. doi:10.1517\/13543776.15.2.125"},{"issue":"8","key":"ref19","series-title":"PLoS One","first-page":"e0272555","article-title":"Long-term outcome of tibial plateau leveling osteotomy using an antimicrobial silver-based coated plate in dogs","volume":"17","author":"Pag\u00e8s G","year":"2022","unstructured":"Pag\u00e8s G, Hammer M, Grand J-G, Irubetagoyena I. Long-term outcome of tibial plateau leveling osteotomy using an antimicrobial silver-based coated plate in dogs. PLoS One. 2022;17(8):e0272555. doi:10.1371\/journal.pone.0272555"},{"issue":"4","key":"ref20","series-title":"JAAPA","first-page":"52","article-title":"Update on surgical site infections: the new CDC guidelines","volume":"31","author":"Borchardt RA","year":"2018","unstructured":"Borchardt RA, Tzizik D. Update on surgical site infections: the new CDC guidelines. JAAPA. 2018;31(4):52-54. doi:10.1097\/01.JAA.0000531052.82007.42"},{"key":"ref21","article-title":"Version 4.2.0. The R Foundation for Statistical Computing","unstructured":"R: A Language and Environment for Statistical Computing. Version 4.2.0. The R Foundation for Statistical Computing. Accessed June 21, 2023. https:\/\/www.R-project.org"},{"key":"ref22","series-title":"The R Foundation for Statistical Computing","article-title":"rstatix: Pipe-friendly Framework for Basic Statistical Tests","author":"Kassambara A","year":"2021","unstructured":"Kassambara A. rstatix: Pipe-friendly Framework for Basic Statistical Tests. Version 0.7.0. The R Foundation for Statistical Computing; 2021. Accessed June 21, 2023. https:\/\/CRAN.R-project.org\/package=rstatix"},{"issue":"6","key":"ref23","series-title":"Vet Comp Orthop Traumatol","first-page":"450","article-title":"Tibial plateau levelling osteotomy implant removal: a retrospective analysis of 129 cases","volume":"24","author":"Thompson AM","year":"2011","unstructured":"Thompson AM, Bergh MS, Wang C, Wells K. Tibial plateau levelling osteotomy implant removal: a retrospective analysis of 129 cases. Vet Comp Orthop Traumatol. 2011;24(6):450-456. doi:10.3415\/VCOT-10-12-0172"},{"issue":"1","key":"ref24","series-title":"Vet Surg","first-page":"106","article-title":"Influence of administration of antimicrobial medications after tibial plateau leveling osteotomy on surgical site infections: a retrospective study of 308 dogs","volume":"49","author":"Clark AC","year":"2020","unstructured":"Clark AC, Greco JJ, Bergman PJ. Influence of administration of antimicrobial medications after tibial plateau leveling osteotomy on surgical site infections: a retrospective study of 308 dogs. Vet Surg. 2020;49(1):106-113. doi:10.1111\/vsu.13337"},{"issue":"5","key":"ref25","series-title":"Vet Surg","first-page":"661","article-title":"Prospective, randomized comparison of the effect of two antimicrobial regimes on surgical site infection rate in dogs undergoing orthopedic implant surgery","volume":"44","author":"Aiken MJ","year":"2015","unstructured":"Aiken MJ, Hughes TK, Abercromby RH, Holmes MA, Anderson AA. Prospective, randomized comparison of the effect of two antimicrobial regimes on surgical site infection rate in dogs undergoing orthopedic implant surgery. Vet Surg. 2015;44(5):661-667. doi:10.1111\/vsu.12327"},{"issue":"1","key":"ref26","series-title":"Vet Comp Orthop Traumatol","first-page":"18","article-title":"Prospective evaluation of surgical wound dressings and the incidence of surgical site infections in dogs undergoing a tibial plateau levelling osteotomy","volume":"32","author":"Giannetto JJ","year":"2019","unstructured":"Giannetto JJ, Aktay SA. Prospective evaluation of surgical wound dressings and the incidence of surgical site infections in dogs undergoing a tibial plateau levelling osteotomy. Vet Comp Orthop Traumatol. 2019;32(1):18-25. doi:10.1055\/s-0038-1676352"},{"issue":"5","key":"ref27","series-title":"Vet Surg","first-page":"930","article-title":"Contributing factors to surgical site infection after tibial plateau leveling osteotomy: a follow-up retrospective study","volume":"49","author":"Hagen CRM","year":"2020","unstructured":"Hagen CRM, Singh A, Weese JS, Marshall Q, Linden AZ, Gibson TWG. Contributing factors to surgical site infection after tibial plateau leveling osteotomy: a follow-up retrospective study. Vet Surg. 2020;49(5):930-939. doi:10.1111\/vsu.13436"},{"issue":"1","key":"ref28","series-title":"Vet Surg","first-page":"2","article-title":"Prospective surgical site infection surveillance in dogs","volume":"44","author":"Turk R","year":"2015","unstructured":"Turk R, Singh A, Weese JS. Prospective surgical site infection surveillance in dogs. Vet Surg. 2015;44(1):2-8. doi:10.1111\/j.1532-950X.2014.12267.x"},{"issue":"4","key":"ref29","series-title":"Antimicrob Agents Chemother","first-page":"2467","article-title":"Preventing implant-associated infections by silver coating","volume":"60","author":"Kuehl R","year":"2016","unstructured":"Kuehl R, Brunetto PS, Woischnig AK,  Preventing implant-associated infections by silver coating. Antimicrob Agents Chemother. 2016;60(4):2467-2475. doi:10.1128\/AAC.02934-15"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/262\/5\/javma.23.10.0592.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/262\/5\/javma.23.10.0592.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/262\/5\/javma.23.10.0592.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T21:46:44Z","timestamp":1727300804000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/262\/5\/javma.23.10.0592.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,1]]},"references-count":29,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.2460\/javma.23.10.0592","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5,1]]}}}