{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T05:24:22Z","timestamp":1741411462054,"version":"3.38.0"},"reference-count":5,"publisher":"American Veterinary Medical Association (AVMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Albumins are protein molecules that account for 50% of total plasma protein. They are imperative in maintaining intravascular colloidal oncotic pressure, act as key scavenger molecules for oxygen free radicals, and perform a major role in transporting numerous substances and in wound healing. Hypoalbuminemia has been reported as the consequence of decreased intake, increased loss, decreased production, and redistribution. While anecdotal evidence of tyrosine kinase inhibitors causing hypoalbuminemia in canine patients exists, to the author\u2019s knowledge there is no formal report to this effect to date. This case report aims to bridge the gap between anecdotal evidence and literature.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>ANIMAL<\/jats:title>\n<jats:p>3-year-old neutered male hound-mix canine.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL PRESENTATION, PROGRESSION, AND PROCEDURES<\/jats:title>\n<jats:p>The patient was presented for recurrent otitis externa refractory to treatments with orbifloxacin\/mometasone\/posaconazole otic suspension, miconazole\/polymyxin B\/prednisolone otic suspension, ketoconazole\/TrizEDTA, and gentamicin\/mometasone\/clotrimazole, which prompted consideration of oral antifungals. Baseline blood work prior to initiation of fluconazole showed elevated alkaline phosphatase. Treatment was initiated with fluconazole, and blood work was rechecked and revealed hypoalbuminemia. Multiple diagnostic tests failed to reveal a cause of hypoalbuminemia.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>TREATMENT AND OUTCOME<\/jats:title>\n<jats:p>Discontinuation of oclacitinib that the patient was being administered resulted in normalization of serum albumin.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>It is unclear whether hypoalbuminemia associated with oclacitinib administration is associated with worse outcomes for pathologies in canine patients; however, this seems to be the case in humans according to some reports. This report aims to take a step in the direction of this knowledge.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.23.10.0600","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T18:50:56Z","timestamp":1702061456000},"page":"1-3","source":"Crossref","is-referenced-by-count":0,"title":["Resolution of hypoalbuminemia in a 3-year-old hound-mix dog after discontinuation of oclacitinib"],"prefix":"10.2460","volume":"262","author":[{"given":"Karthika","family":"Parvathy","sequence":"first","affiliation":[{"name":"University Animal Hospital, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"S1","key":"ref1","series-title":"J Am Vet Med Assoc","first-page":"S36","article-title":"Oclacitinib 10 years later: lessons learned and directions for the future","volume":"261","author":"Marsella R","year":"2023","unstructured":"Marsella R, Doerr K, Gonzales A, Rosenkrantz W, Schissler J, White A. Oclacitinib 10 years later: lessons learned and directions for the future. J Am Vet Med Assoc. 2023;261(S1):S36-S47. doi:10.2460\/javma.22.12.0570"},{"issue":"5","key":"ref2","series-title":"Vet Dermatol","first-page":"479","article-title":"Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis","volume":"24","author":"Cosgrove SB","year":"2013","unstructured":"Cosgrove SB, Wren JA, Cleaver DM,  Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. Vet Dermatol. 2013;24(5):479-e114. doi:10.1111\/vde.12047"},{"issue":"2","key":"ref3","series-title":"Vet Dermatol","first-page":"107","article-title":"Long-term effects of ciclosporin and oclacitinib on mediators of tolerance, regulatory T-cells, IL-10 and TGF-\u03b2, in dogs with atopic dermatitis","volume":"34","author":"Herrmann I","year":"2023","unstructured":"Herrmann I, Mamo LB, Holmes J, Mohammed JP, Murphy KM, Bizikova P. Long-term effects of ciclosporin and oclacitinib on mediators of tolerance, regulatory T-cells, IL-10 and TGF-\u03b2, in dogs with atopic dermatitis. Vet Dermatol. 2023;34(2):107-114. doi:10.1111\/vde.13140"},{"issue":"3","key":"ref4","series-title":"Vet Dermatol","first-page":"171","article-title":"Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life","volume":"26","author":"Cosgrove SB","year":"2015","unstructured":"Cosgrove SB, Cleaver DM, King VL,  Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. Vet Dermatol. 2015;26(3):171-179, e35. doi:10.1111\/vde.12194"},{"article-title":"Atypical hypoadrenocorticism in the canine patient: a case report","author":"Beckman SA","key":"ref5","unstructured":"Beckman SA. Atypical hypoadrenocorticism in the canine patient: a case report. Paper presented at: Mississippi State University College of Veterinary Medicine Class of 2018 Clinicopathologic Conference; November 10, 2017."}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/262\/3\/javma.23.10.0600.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/262\/3\/javma.23.10.0600.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/262\/3\/javma.23.10.0600.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T13:07:03Z","timestamp":1741352823000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/262\/3\/javma.23.10.0600.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":5,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.2460\/javma.23.10.0600","relation":{},"ISSN":["0003-1488"],"issn-type":[{"type":"print","value":"0003-1488"}],"subject":[],"published":{"date-parts":[[2024,3,1]]}}}