{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T17:08:13Z","timestamp":1774026493824,"version":"3.50.1"},"reference-count":17,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2007,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To determine the effects of 8 days of light to heavy exercise on gastric ulcer development in horses and determine the efficacy of omeprazole paste in preventing gastric ulceration.<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Randomized, controlled, multicenter clinical trial.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u2014102 horses with normal-appearing gastric mucosa on endoscopic examination that were in light to heavy training.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Horses at 4 trial locations were allocated into replicates and sham dosed orally (empty syringe) or treated with a paste formulation of omeprazole (1 mg\/kg [0.45 mg\/ lb], PO) once daily for 8 days. Training regimens varied among locations and included early training for western performance events; walking, trotting, and cantering in a mechanical exerciser; and race training (2 locations). Prevalences of gastric ulceration at the completion of the 8-day treatment period were compared between groups.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014At the end of the 8-day treatment period, the proportion of omeprazole-treated horses free from gastric ulceration (88%) was significantly higher than the proportion of sham-dosed horses free from gastric ulceration (27%).<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results showed that horses in light to heavy training for as short as 8 days were at risk of developing gastric ulcers and that administration of omeprazole paste decreased the incidence of gastric ulcers.<\/jats:p>","DOI":"10.2460\/javma.230.11.1680","type":"journal-article","created":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T13:40:21Z","timestamp":1180705221000},"page":"1680-1682","source":"Crossref","is-referenced-by-count":27,"title":["Effects of short-term light to heavy exercise on gastric ulcer development in horses and efficacy of omeprazole paste in preventing gastric ulceration"],"prefix":"10.2460","volume":"230","author":[{"given":"Gary","family":"White","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott R.","family":"McClure","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Sifferman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E.","family":"Holste","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candis","family":"Fleishman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz G.","family":"Cramer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Equine Vet J Suppl","first-page":"68","article-title":"Gastric ulcers in horses: a comparison of endoscopic findings in horses with and without clinical signs","volume":"7","author":"Murray","year":"1989"},{"key":"ref2","series-title":"Equine Vet J","first-page":"368","article-title":"Factors associated with gastric lesions in Thoroughbred racehorses","volume":"28","author":"Murray","year":"1996"},{"key":"ref3","series-title":"J Vet Intern Med","first-page":"218","article-title":"Gastric ulcers in Standardbred racehorses: prevalence, lesion description, and risk factors","volume":"17","author":"Dionne","year":"2003"},{"key":"ref4","series-title":"Equine Vet Educ","first-page":"221","article-title":"Field survey of the prevalence of gastric ulcers in Thoroughbred racehorses and on response to treatment of affected 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Suppl","first-page":"40","article-title":"Induction and maintenance of gastric ulceration in horses in simulated race training","volume":"29","author":"Vatistas","year":"1999"},{"key":"ref10","series-title":"Equine Vet J Suppl","first-page":"81","article-title":"Efficacy of omeprazole paste in the treatment and prevention of gastric ulcers in horses","volume":"29","author":"Andrews","year":"1999"},{"key":"ref11","series-title":"J Am Vet Med Assoc","first-page":"775","article-title":"Gastric ulcer development in horses in a simulated show or training environment","volume":"227","author":"McClure","year":"2005"},{"key":"ref12","series-title":"Am J Vet Res","first-page":"1599","article-title":"Effects of intermittent feed deprivation, intermittent feed deprivation with ranitidine administration, and stall confinement with ad libitum access to hay on gastric ulceration in horses","volume":"57","author":"Murray","year":"1996"},{"key":"ref13","series-title":"Equine Vet J","first-page":"554","article-title":"Histologic characteristics of induced acute peptic injury in equine gastric squamous epithelium","volume":"33","author":"Murray","year":"2001"},{"key":"ref14","series-title":"J Am Vet Med Assoc","first-page":"1681","article-title":"Efficacy of omeprazole paste for prevention of gastric ulcers in horses in race training","volume":"226","author":"McClure","year":"2005"},{"key":"ref15","series-title":"J Am Vet Med Assoc","first-page":"1685","article-title":"Efficacy of omeprazole paste for prevention of recurrence of gastric ulcers in horses in race training","volume":"226","author":"McClure","year":"2005"},{"key":"ref16","series-title":"Am J Vet Res","first-page":"413","article-title":"Effects of hydrochloric, valeric, and other volatile fatty acids on pathogenesis of ulcers in the nonglandular portion of the stomach of horses","volume":"64","author":"Nadeau","year":"2003"},{"key":"ref17","series-title":"Am J Vet Res","first-page":"744","article-title":"Effect of hydrochloric acid, pepsin, or taurocholate on bioelectric properties of gastric squamous mucosa in horses","volume":"63","author":"Widenhouse","year":"2002"}],"container-title":["Journal of the American Veterinary Medical 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